Posted by admin on Apr 30, 2023 in |
In mid-November 2021, the new OMICRON variety was first discovered in South Africa. As of today, the OMICRON version already appeared on December 15, 2021. Around 77 countries are affected, with the bulk of cases originating in the United States, India, the United Kingdom, and South Africa. OMICRON-positive instances were also reported. The first mortality associated with the novel COVID-19 mutation was reported in the United Kingdom. Recently, a sister variant of OMICRON, 21L or BA.2, has also been discovered. Due to its enormously high number of mutations, viewed enhancement in immune evasion and transmissibility, OMICRON was developed as a new variant of concern (VOC) by the WHO on 26 November 2021. On a global pandemic scale, positive selection of SARS-CoV-2 mutations appears to have begun in late 2020. Since then, the virus has been evolving on two fronts: immune evasion and enhanced transmissibility, as expressed by Delta. This review elaborates the effects of drugs in the management of...
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Posted by admin on Mar 31, 2023 in |
Selenium (Se) is a fundamental micro nutrient of life forms and has significant capacity. It takes part in the elements of seleno protein in a few habits. As of late, this has drawn in much consideration because of its restorative potential against a few illnesses. Numerous natural Se-containing compounds, both natural and artificial, have been identified, studied and used in the treatment of cancer and other illnesses. Regardless, the “precise intracellular targets”, “signaling pathways” influenced and instruments of cell demise drew in following therapy change depending on the synthetic features of the seleno substance. Normally happening natural Se compounds, other than including a huge anti tumor action with an obvious capacity to forestall metastasis, additionally appear to have less aftereffects and less foundational impacts as detailed for some, inorganic Se...
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Posted by admin on Mar 31, 2023 in |
For almost five decades, from its application in preserving blood plasma to stabilizing pharmaceuticals and biopharmaceuticals, lyophilization has been used in life sciences. Lyophilization is a popular drying technique for preserving various drugs, formulations and biological materials such as proteins, plasma, and living cells. The researchers have made significant efforts to develop lyophilized nanoparticulate drug delivery formulations. During lyophilization, biological products and vaccines could be increased by removing solvents and the shelf-life of injectables. Thus, lyophilization unstable or heat-sensitive drugs/biologicals can be dried at low temperatures without damaging their physical structure. Lyophilized products can be reconstituted quickly and easily, improving shelf life and easy transportation. Vast applications of lyophilization in the Pharmaceutical Area established the importance of lyophilization techniques in the pharmaceutical field. The present review aims to update recent and advanced applications of Lyophilization techniques in Pharmaceuticals and biological products such as Antibiotics, Vaccines, proteins, enzymes, and...
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Posted by admin on Mar 31, 2023 in |
Numerous disorders are caused by inflammation, and recent epidemics have prompted public health concerns. The fact that there are so many anti-inflammatory medications available doesn’t change the fact that they frequently don’t work because they pose a severe risk of gastrointestinal toxicity with both acute and chronic use, hematologic toxicity with acute use, and nephrotoxicity with chronic use. Curcumin’s clinical value was, however, constrained by its low absorption. Therefore, it is crucial to find new anti-inflammatory medications, and natural products are a great place to start. One such natural substance, curcumin, is a promising therapeutic candidate because of its stability, solubility, and low toxicity. Research has indicated its inhibitory effect on prostaglandin E2 and COX-2 protein formation, as well as on phorbol ester- and CD-induced COX-2 mRNA expression and PGE2 synthesis, among other things. The mechanisms either entail inhibiting cyclooxygenases (COX) and other inflammatory enzymes. This study covers the current state of knowledge with an emphasis on the anti-inflammatory properties of curcumin and their potential molecular...
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Posted by admin on Mar 31, 2023 in |
Since ancient times, plants have been used for medicinal purposes for their various therapeutic potentials and safest to modern allopathic medicines. Regularly phytochemicals are proving to be modern medicine with novel drug delivery systems by treating different diseases and disorders. Phytochemical compounds need improvement of efficacy and patient’s compatibility to deliver in various diseases, e.g., high blood pressure, microbial, coronary heart disease, cancers, diabetes, inflammation, etc., also require a rational approach. Nanotechnology is a promising drug delivery approach for targeted or site-specific phytoconstituent delivery. Especially, Nanogels are the most rational approach for targeting skin diseases and enhancing bioavailability. Phytoconstituents or plant extract-loaded nanogels have been reported in in-vitro and in-vivo activities for different skin disorders like aging, acne, skin infection, etc. Nanogels, as a novel drug delivery system, may reduce toxicity and improve the bioavailability of the incorporated drug. The present review is focused on various phytomedicines that have been used in treating skin aging and acne, nanogel formulations prepared, and the effectiveness of both phytochemicals and nanotechnology for...
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