Posted by admin on Feb 28, 2023 in |
The global market size was valued at $ 380.2 billion in 2019 and is projected to reach $463.5 billion by 2027, registering a CAGR of 5.3% from 2021 to 2027. Cosmetics have become an in-dispersible feature of the modern lifestyle. The use of cosmetics has increased in males and women in daily routine, which complements the growth of global cosmetic market demand. The skin care industries are trying to develop and market new and efficient products with advanced features that will affect appearance and therapeutic effects. The new development in cosmeceuticals has emerged in the form of Nanocosmeceuticals with the aid of nanotechnology in cosmeceuticals. Since, extrinsic factors like sunlight, dry weather, pollutants, stressful life, poor diet and inadequate sleep are leading to dull and diseased skin, nails and hair can be efficiently treated to get the good looking appearance, flawless complexion and blemish-free skin with the help of nanocosmeceuticals with various nanomaterials like liposomes, niosomes, transfersomes, cubosomes, ethosomes, dendrimers, solid lipid nanoparticles, nanoemulsions, gold nanoparticles, fullerenes, nanocapsules potentially...
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Posted by admin on Feb 28, 2023 in |
People throughout the world have long used various fruits, leaves, and plant parts as nutraceuticals and valuable sources of herbal treatments. Apples (Malus domestica) are a popular fruit with a high level of medicinal efficacy, whose seeds have also demonstrated a very high therapeutic and nutritional value when ingested in the right amount and form (apple seed flour or oil). Found in cold temperate regions worldwide and in the states of Jammu and Kashmir, Himachal Pradesh, Uttaranchal, Uttar Pradesh and Arunachal Pradesh in India. Malus domestica fruit, peels and seeds, when extracted in alcohol or acetone medium, show a high content of proteins, fatty acids, dietary fibres, polyphenols, vitamins and minerals, polysaccharides, phytosterols, pentacyclic triterpenes and cyanogenic glycosides (amygdalin). Polyphenols like proanthocyannidin, catechin, quercetin, phloridzin are very effective in treating hyperglycemia, cholesterol, neuropsychiatric diseases, cancer, and gastrointestinal disorders. Another cytotoxic component present in the seeds is amygdalin, which shows anti-proliferative and anti-inflammatory properties. Other than this, pectin, a polysaccharide (peel and seeds), phytosterols (leaves, stem, root, seeds), pentacyclic triterpenes...
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Posted by admin on Feb 28, 2023 in |
Structure-Activity relationship (SAR) only identifies the chemical group responsible for producing the target biological effect in the organism. It was first present in 1865, structural activity relationship was refined dates back to the nineteenth century and now it has advanced from QSAR to 3D QSAR. Quantitative Structure-Activity Relationships (QSAR) are attempted to correlate the structural and biological properties of compounds or molecules. QSAR is used in drug design and medicinal chemistry. By using QSAR, scientists predefined toxicity related to organic molecules and determined the perfect potential biological activity that helps produce drug moiety. Group Based-Quantitative Structure-Activity Relationship (G-QSAR) is fragment dependent method which bases on molecule descriptors. Statistical parameters validate the GQSAR method. The cross-term fragment descriptor is used in GQSAR to study the relation of molecular fragments and variation in biological-based response. It provides a clue for designing new molecules and predicting their activity. In this article, we mainly concentrate on the various QSAR model such as Hansch Analysis, Free Wilson Analysis, various physicochemical properties, QSAR development process,...
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Posted by admin on Feb 28, 2023 in |
India is the peninsula of the herbal hub, in which the ayurvedic system of medicine has flourished as enlightenment in the field of medicine. Plants had played a vital role since ancient times when people used plant derivatives as a source of the drug. Currently, some spices and medicinal plants have become the preponderant source of drug discovery in research for treating diverse forms of the disease, including cancer, due to having anticancer, antimicrobial, and antioxidant properties. Several spices and medicinal plants are potential sources for the forestallment and treatment of varied diseases, which contains several important bioactive compounds and phytochemical properties. Antioxidant activity can be arrested by flavonoids, tannins, phenolic acids, carotenoids, etc., depending on their physical structure. But in plants, Polyphenols are the most abundant antioxidant having a splendid ability to capture oxidative free radicals. The present study favours detailed wisdom on the antioxidant activities of nearly 80 different Indian medicinal plants in Maharashtra and Tamil Nadu which would be more beneficial for further research to develop...
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Posted by admin on Feb 28, 2023 in |
In hospitals, blood transfusions are a common occurrence. Because blood-related products are limited and have a range of adverse side effects, researchers have worked on artificial blood components for nearly 40 years. It is crucial to develop effective and selective alternatives for natural blood products. Artificial blood is a useful idea in transfusion medicine wherein clearly defined compounds perform the functions of oxygen transport and distribution in the body to enhance allogeneic human blood transfusion. Several molecules are created over a long period of time to achieve this goal, and ongoing modifications are performed in the pursuit of the ideal blood substitute. Currently, perfluorocarbons (PFC) or haemoglobin derived from outdated human/bovine blood (Hemoglobin Based Oxygen Carriers; HBOC) are used to manufacture artificial blood. The focus of this review paper is to provide a comprehensive view of different developed products that can be used as blood...
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