Posted by admin on Jan 31, 2023 in |
Diabetes Mellitus is a prevalent global health problem commonly known as diabetes, a metabolic disease resulting in high blood sugar levels. India considered as “Capital of Diabetes” and more than 61 million Indians suffer from diabetes. Plants are incredible natural reservoirs of phytochemicals and vital medicines. Momordica charantia (MC), commonly known as bitter melon, has high phytochemical content and is effective against diabetes mellitus. Momordica charantia is also considered as “vegetable insulin” because it contains alkaloids and peptides which resemble insulin and Charantin, which are responsible for the hypoglycaemic activity. The mechanism of action of bitter melon has been discussed and mentioned. Medicated Momordica charantia chewable lozenges are intended to dissolve or disintegrate slowly in the mouth and release the active constituent slowly because the Lozenges dosage form has good oral retention time in, increases bioavailability, and decreased gastrointestinal irritation. This dosage form can be used for both local and systemic therapy. Our hypothesis revolves around the formulation of Momordica charantia chewable lozenges for treating diabetes mellitus. Various shreds...
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Posted by admin on Jan 31, 2023 in |
Enzyme Alanine racemase is well known for performing a predominating role in mycobacterium cell wall synthesis. D-alanine provided by Alanine racemase serves as a peptidoglycan precursor, utterly vital for maintaining the growth and integrity of the cell wall. The lipid-rich mycobacterium cell wall is prevalent amidst prokaryotes with immense potential of becoming a therapeutic target for new drug discovery. The imperative role of Alanine racemase in mycobacterium cell wall synthesis implies that its inhibition is of uttermost priority in order to deal with various pathogenic infections. Interference with metabolic processes, lack of specificity, and cellular toxicity caused by several known inhibitors prompted renewed efforts by researchers to discover new and improved inhibitors with better therapeutic indexes. This paper provides an overview of the updated status of reported Alanine racemase inhibitors based on shreds of evidence in literature so that more precise inhibitors could be explored, designed, and identified to rationalize the overall drug discovery process, which will be true serendipity for the...
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Posted by admin on Jan 31, 2023 in |
The brain alternates between wakefulness, nonrapid eye movement (NREM) sleep and rapid eye movement (REM) sleep during sleep. Sleepwalking, sleep terrors, sleepwalking and sleep paralysis are common examples of the behavioral manifestations linked with parasomnias or partial arousals from sleep. Sleep Paralysis is a condition in which someone lying supine position, about drop off to sleep or just upon waking from sleep realize that she/ he unfit to speak or walk or cry out, this may lose many seconds or moments, occupationally longer. The sensation of being paralyzed can be accompanied by various vivid and powerful sensory sensations, such as mentation in visual, aural, and tactile modalities and a distinct sense of presence. People always feel that they’ve been hanging by someone or wrong, sometimes, cases report this type of problem. They feel that wrong is following, sitting behind them going to be attacked is the condition they feel, in this. Composition reviewed the causes of sleep palsy and what’s sleep; many sleep diseases are bandied then. This review...
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Posted by admin on Jan 31, 2023 in |
In pharmaceuticals formulation, poorly aqueous soluble medications are becoming more difficult to administer into dosage form as 40-50% of new chemical entities discovered are reported to be poorly aqueous soluble, preventing appropriate absorption from the GI tract. Oral administration is preferred over other forms of administration due to its ease of administration & painless approach. The main problem in the oral dosage form is poor bioavailability due to aqueous solubility. As a result, formulation scientists are employing several ways to improve the absorption and bioavailability of poorly aqueous soluble medication, which is difficult. The different strategies used are nano-suspensions, complexation, pH modification, solid dispersion, liposome, solid lipid nanoparticle (SLN), Self-Emulsifying Drug Delivery systems (SMEDDS) and other techniques are used. In the last few decades, pharmaceutical research has been highly diversified for self-emulsifying systems: from micrometer to nanometer size. Therefore, (SMEDDS) has gained much attention as it requires a minimum dose, and the API can be protected into the hostile environment in the gut. It also forms the droplet size...
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Posted by admin on Jan 31, 2023 in |
Schiff bases are generally aldehyde or ketone-like compounds in which an imine or azomethine group replaces the carbonyl group. They are versatile and exhibit a broad range of pharmacological activities as antimicrobial, antibacterial, antifungal, antiviral, and anticonvulsant. Anti-cancer activity has been used widely for industrial purposes or therapeutic use. Thus, Schiff bases are highly desired environment-friendly organic compounds used for various therapeutic activities. The goal of reviewing all therapeutic properties is to enhance and modify the antimicrobial properties of the Schiff base. Due to the pandemic conditions of the past few years, it is now necessary to have a compound with strong antimicrobial properties to fight any...
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