Posted by admin on Oct 31, 2022 in |
One of the most prominent issues with Down Syndrome (DS) individuals is the cognitive deficits that come with early-onset Alzheimer’s disease (AD). Numerous mechanisms are accountable for neurodegeneration and declined cognition, including impairment in neurogenesis leading to hypocellularity in the cortex, cerebellum and hippocampus, altered dendritic morphology, and altered synapses plasticity. Pharmacotherapy is typically based on stimulating the proliferation of the neuronal count. Previously it has been hypothesized that mitochondrial dysfunction followed by an increase in the levels of free radicles plays a critical role in the impairment of the CNS, which results in a loss of neuronal function and viability. And Hence, mitochondrial dysfunction can be portrayed as a major cause in the pathogenesis of neurodegenerative disorders associated with cognitive deficits. There is a rising curiosity about the potential of the natural polyphenol compounds for improving memory and learning and also the general cognitive capability and reversing the age-related declinations. The polyphenols act by directly affecting the mitochondrial dysfunction or modulating the cellular signaling pathways that regulate the...
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Posted by admin on Oct 31, 2022 in |
Diabetes Mellitus (DM) is a persistent metabolic cluster of diseases that involves erroneously excessive blood glucose levels. The polygenic disorder cluster of diseases includes Type I, Type II, Physiological state polygenic disorder (Gestational diabetes), Infant polygenic disorder (Neonatal diabetes), Maturity Onset Diabetes of the Young (MODY), and secondary causes because of endocrinopathies, steroid use and-so-on. Type I and Type II are the principal subtypes of DM, which are classically consequences of defective insulin secretion (Type I Diabetes Mellitus-TIDM) and /or action (Type II Diabetes Mellitus-TIIDM). TIDM likely gets access in kids or adolescents, whereas TIIDM impacts middle elderly and older adults who’ve extended hyperglycemia because of a bad way of life, lack of exercise, and nutritional choices. There is a vital distinction between TIDM and TIIDM, and consequently, every kind has diverse aetiologies, treatments, and medical presentations. This review article provides acquired facts regarding recently recommended guidelines for diabetes and its...
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Posted by admin on Oct 31, 2022 in |
Diabetes mellitus is an associated symptom of untreated high blood sugar, and it’s linked to long-term organ damage, dysfunction, and failure in adults. The ongoing increased scale of Diabetes mellitus will severely impact the long-term health of the global population and the global economy unless appropriate prevention and management strategies are established. Plants were studied using streptozotocin-induced diabetes rodents’ in-vivo animal models. As per the World Health Organization, more than 90% of people in underdeveloped countries use natural medicine (plants and their products) for primary health care. Approximately 800 plants have been identified to have anti-diabetic properties. The following are the most commonly utilized plant extracts to help regulate blood glucose: Allium cepa (Onion), Allium sativum (Garlic), Aloe barbadensis (Aloe vera), Azadirachta indica (Neem), Beta vulgaris (Beetroot), Catharanthus roseus (Vinca rosea), Cinnamomum cassia (Cinnamon), Curcuma longa (Curcumin), Eugenia jambolana (Jamun), Hibiscus rosa-sinesis (Gurhal), Mangifera indica (Mango), Momordica charantia (Karela), Nigella sativa (Kalonji), Ocimum sanctum (Tulsi), Panax ginseng (Ginseng), Pterocarpus marsupium (Vijyasar), Psidium guajava (Guava), Tamarindus indica (Tamarind), Trigonella foenum-graecum...
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Posted by admin on Oct 31, 2022 in |
Psidium guajava Linn is an herbal remedy used in Ayurveda as a traditional system of medicine in ethnomedicine. It is a tropical evergreen plant that grows in tropical and subtropical climates. It has a wide variety of nutritional components. The whole plant and various parts of the plants possess different types of therapeutic activity, such as Tannin, phenols, triterpenes, flavonoids, essential oils, saponins, carotenoids, lectins and vitamins, dietary fiber, fatty acids, and other active components of guava plants demonstrate pharmacological activity. The fruits and leaves can be freely consumed for their good taste and various nutritional benefits and can be used in various treatments. The most active constituents, like tannins, flavonoids, terpenoids, etc., are mainly found in leaf parts. Guava has a high nutritional value, as it is high in dietary fiber, vitamins C and A, folic acid, dietary minerals, potassium, copper, and manganese. Guava leaves have phenolic compounds which are reported to possess antibacterial, antistress, antigenotoxic, anti-inflammatory, anti-hyperglycemia, anti-rotavirus, cytotoxic, hepatoprotective, etc. In this review, compile all the...
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Posted by admin on Oct 31, 2022 in |
The Petasis boron–Mannich process, also referred to as the Petasis reaction, combines boronic acid, an amine, and a carbonyl derivative in a multi component coupling process. Recent progress on petasis reaction is discussed in this review. The various merits of petasis reaction over the other multi-component coupling reactions are explain here. Noncanonical substrates are used to explore the expansion of a variety of petasis reactions, including two–component, three–component, and four–component reactions, processes, and products. In this review, Microwave–assisted reactions are also explored. The optimal conditions are involved in the microwave heating process. The conditions are successfully applied for petasis reaction. Different solvents are used in petasis boron-mannich reactions, such as glycerol and water. Both solvents are suitable for the reaction and give favorable yield. The reactivity along with numerous synthetic applications of the Petasis reaction are given in this review. The natural product synthesis are given by Petasis boron-Mannich reaction in which loline alkaloid and sialic acid synthesis are...
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