Posted by admin on Dec 31, 2022 in |
Peptic ulcer is an excavation of mucosa and may extend to the submucosal layer. The bacterium Helicobacter pylori is regarded as the most common cause of infection. Long-term use of NSAIDs (non-steroidal anti-inflammatory disease drugs) like Aspirin, Diclofenac, and Naproxen and stress were also regarded as causes of ulceration. Ancient technology of synthesizing and utilizing plant-based medicine is known from time immemorial. Chronic and complicated diseases have been cured with plant-based products. Considering their importance in manufacturing new medicines, their efficacy and safety have become a major concern. This literature review reviews some investigated plants that have shown promising results in mitigating peptic ulcers at different doses. Preliminary phytochemical screening of these herbs has shown the presence of important secondary metabolites like flavonoids, alkaloids, terpenoids, tannins which are responsible for the anti-ulcer activity. Acute toxicity studies have proved the safety of the selected plant extracts. This article reviews the overall active constituents, anti-ulcer, gastro protective activity of some medicinal plants investigated between...
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Posted by admin on Dec 31, 2022 in |
Any bodily harm, such as damage to the skin’s epidermis and disruption of its normal architecture and function, is referred to as a wound. The significance of wound healing has been known since ancient times. Several attempts have been made to design innovative wound dressings composed of the finest materials for speedy and successful wound healing. Medicinal herbs greatly aid the wound healing process. Many researchers have concentrated in recent decades on creating innovative wound dressings that combine medicinal plant extracts or their purified active components, which might be utilized instead of standard wound dressings. Several researchers have looked at the mechanisms of action of different herbal medicines in the wound healing process. This work aims to emphasize and examine the mechanical viewpoint of wound healing mediated by natural compounds. Some herbal medications stimulate re-epithelialization, angiogenesis, granulation tissue development, and collagen fiber deposition by increasing the production of vascular endothelial growth factor (VEGF) and transforming growth factor (TGF-α). Other wound dressings containing herbal medicines decrease the production of tumour...
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Posted by admin on Dec 31, 2022 in |
BioMarin Pharmaceutical is developing Vosoritide, a modified recombinant human C-type natriuretic peptide (CNP) analogue for the treatment of achondroplasia. A gain-of-function mutation in the fibroblast growth factor receptor 3 gene (FGFR3), a negative regulator of bone growth, causes achondroplasia. Vosoritide works to restore chondrogenesis by attaching to the natriuretic peptide receptor B (NPR-B), which inhibits the hyperactive FGFR3 gene’s downstream signalling pathways. In August 2021, the European Union approved Vosoritide for the treatment of achondroplasia in children under the age of two whose epiphyses are not closed; the diagnosis of achondroplasia should be validated by genetic testing. In the United States, the medication is also undergoing regulatory assessment for the treatment of achondroplasia and clinical trials. Several countries are in the process of developing. The milestones in the development of vosoritide that led to this first approval for achondroplasia in children under the age of two whose epiphyses are not closed are summarized in this article. Vosoritide is a medication that was designed to treat achondroplasia and has shown...
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Posted by admin on Dec 31, 2022 in |
Poisonberry is the colloquial name for Solanum indicum Linn. It grows to over one meter in height and is thorny and densely branched. It is usually found in India’s warmer regions, up to an altitude of 1500 meters. This important medicinal plant treats respiratory infections, skin infections, ulcers, dyspepsia, cough, and stomach discomfort in Ayurveda and Siddha, the Folk and Traditional Indian systems of medicine. The findings of evidence-based tests are compared to the folkloric use of Solanum indicum Linn. Despite being a rich source of solanine, one of the plant’s most feared poisons, Solanum indicum has proved its value as a reservoir of antioxidants with hepatoprotective, anti-tumor, cytostatic, anti-convulsant, anti-ulcerogenic and anti-inflammatory properties. The evaluation examines whether or not proper scientific methods have been followed in developing experimental evidence supporting Solanum indicum traditional applications, including in-vitro, in-vivo, and clinical trials. The study’s goal is to compile the most recent information on pharmacognostic research, medicinal purposes, chemical constituents, and other pharmacological effects. Solasodine, Solamargine, Solasonine, Solanine, and Solanidine were...
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Posted by admin on Dec 31, 2022 in |
Breast cancer (BC) is one of the most prevalent cancers in women; there were 2.3 million women diagnosed with breast cancer globally. Unfortunately, most anticancer drugs have reported high Potential toxicity, mutagenic and carcinogenic side effects. Existing treatments can neither stop its propagation and/or recurrence nor are specific for cancer cells. Hence the side effects on healthy tissues and cells are common. There is a need to improvise the patient’s quality of life and the efficiency of the treatments, which can be potentiated with reduced toxicity. Nanotechnology has vast applications in diagnosing, treating and preventing breast cancer. Nanotechnology offers new alternatives for the design that can be used in cancer treatment and has now become a very promising tool for its use against breast cancer. In this review, we provide a broad overview on the use of nanotechnology in the fight against breast cancer. We have analyzed the latest research (2019-2021) in nanotechnology as a potential step for breast cancer treatment. We also give a brief summary of the...
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