Posted by admin on Jul 31, 2022 in |
Infectious diseases are the most significant cause of fatalities worldwide. Staphylococcus aureus could be a common human infective microorganism that will trigger various infectious diseases, like soft tissue and skin infections, osteomyelitis, bacteremia, endocarditis, and fatal respiratory illnesses. In recent decades, because of the evolution of microorganisms and the abuse of antibiotics, the drug resistance of S. aureus has been stepped by step exaggerated, and the infection rate has risen worldwide. Accumulating proof has demonstrated that the resistance mechanisms of S. aureus are complicated, that is, resistant to several types of antibiotics. Multiple antibiotic-resistant Staphylococcus aureus is one of the common causes of severe nosocomial infections, and the gastrointestinal tract is an important source of its transmission. Productive treatment remains difficult and needs the analysis of each novel anti-microbial and connected aspect of care, like communicable disease consultation, diagnostic technique and supply source. This review focuses on developing resistance to currently used antibiotics and examines prospects for new antibiotics and the known use of drug...
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Posted by admin on Jul 31, 2022 in |
From the primordial times’ plants are standard as a chief resource for mankind. In the traditional system of medicine, Indian sarsaparilla Hemidesmus indicus (Family Asclepiadaceae) is a commonly well-known medicinal plant. This plant contains various phytoconstituents belonging to flavonoids, tannins, glycoside, sterols, and volatile oil. In the traditional system, the plant Hemidesmus indicus is used for loss of voice, cough, menstrual disorders, asthma, abdominal swelling, fever, skin diseases, ulceration due to syphilis and anthelmintic, etc. Aim and Objective: In this review article, we aim to represent an exhaustive update on the ethnobotanical review, phytoconstituents review, pharmacological review, toxicity study, and marketed formula. Materials and Method: Widely used international databases such s PubMed, Scopus, Google search, and JSTOR were searched, and various books like the flora of Orissa, Pharmacology of medicinal plant and natural product, the Indian meteria medica etc. were also searched. Result: Hemidesmus indicus played an important role in traditional Indian medicine. The important pharmacological uses of H. indicus are Anti-inflammatory, Anti-leprotic, Anti-oxidant, Anti-arthitic, Anti-microbial, Anti-diarroheal, woud healing,...
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Posted by admin on Jul 31, 2022 in |
hERG (human ether-à-go-go-related gene) encodes a potassium ion channel which involved in ventricular repolarization at the end of a cardiac action potential. Mutations in hERG channel result in torsade’s de pointes. The cardiotoxicity is mainly due to the prolongation of the QT interval caused by the blockage of hERG. Indeed, many therapeutic drugs are withdrawn from the market as well as drug candidates may fail in the late phases of drug discovery because of cardiotoxicity. The ICH S7B and ICH E14 are the safety pharmacology guidelines recommended for evaluating new chemical entities. In the early phase of drug discovery, it is important to screen the compound for the activity on the hERG channels. Many hERG assays are available, including Fluorescent Membrane Potential Sensitive Dye Method, Radioactive Ligand Binding Method, Fluorescence Polarization Ligand Binding Method and Rubidium Flux method, Manual Patch-Clamp Method and automated Patch-Clamp Method, Langendorff’s perfused isolated heart method, Non-Invasive Telemetry, and Wireless Telemetry. This review is focused on hERG assay and provides additional information about the long...
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Posted by admin on Jul 31, 2022 in |
Herbal remedies have been utilized in medical practice for thousands of years and are recognized notably as a significant and widely available resource for health treatment. Traditional botanicals and herbal supplements have been deemed to be mild, non-toxic and even safe due to their natural nature. Acacia leucophloea (Roxb.) Willd. belongs to the family Mimosaceae, recognized as a diverse resource of components possessing bioactive qualities. The various parts of Acacia species are used as local treatments for diverse ailments. Especially, the bark is historically utilized for treating several illnesses in the Ayurveda system of medicine. Tanning is found in the bark of Acacia species, and fatty oil is found in the seeds. Analgesic, anti-inflammatory, anti-viral and anti-bacterial properties of A. leucophloea stem bark are used to treat inflammatory conditions such as bronchial inflammation and coughing, biliousness of the skin and leucoderma. Acacia leucophloea has a wide range of potential uses and this review focuses on its pharmacological effects in...
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Posted by admin on Jul 31, 2022 in |
Comprehensive search of previously published research was conducted in PubMed, Science Direct, Scopus, and google scholar databases for studies published between 2012 and August 2021. The keywords used in combination to search for articles included Nigella sativa and “Gynecology”. In the first stage, the total articles obtained from searching the above databases using the above keywords were pooled together, and duplicate articles were removed. The remaining articles were primarily screened by reading the title and abstracts and selecting the most relevant articles. In the last stage, articles were reviewed again by reading the entire article, and those that did not meet the inclusion requirements were eliminated. A manual search was conducted using the reference list of the included research publications to collect additional data. In the various databases, the literature search found the following number of research articles: PubMed (n=11), Science Direct (n=35), Scopus (n=07), and Google Scholar (n=1070). After removing duplicates, there were 1062 articles. Those articles were further screened first by reading topics and abstracts and secondly,...
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