Posted by admin on Jun 30, 2022 in |
Polysaccharides are composed of monosaccharide’s linked by glycosidic bonds. These are abundantly available and are obtained from renewable resources. Polysaccharides provide an array of primary structures and conformations used in the pharmaceutical industry. Natural polysaccharides properties can be substantially modulated by chemical, physical, and enzymatic modifications and have received increased attention to expanding the landscape of application of polysaccharides in diverse sectors. Modifying the natural polysaccharides properties and structures gives functionally improved polysaccharides with excellent bioavailability, biocompatibility, structural stability, and versatile chemical. By modifying the physicochemical properties of polysaccharides, systems like micelles, hydrogels, liposomes, niosomes and vesicles are produced. The modified polysaccharides have a remarkable application in gene delivery, targeted cancer therapy, delivery of the drug, wound dressings, tissue engineering, nanocarriers, biosensors, pharmaceutical formulations, agricultural applications, and food industry. This article covers different types of polysaccharides and distinct methodologies applied during the new modified synthesis of polysaccharides and also the study of their properties after modification. This review also highlights the application of these modified polysaccharides in various pharmaceutical,...
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Posted by admin on Jun 30, 2022 in |
ACAT enzyme is found in human body and it maintains cholesterol homeostasis in the cell. This leads to deposition of cholesterol in our body as cholesteryl esters. Freely deposited cholesterol in the membranes of the cells is cytotoxic. This deposition causes atherosclerosis, Alzheimer’s disease, Xanthelasma, etc. The first substrate for ACAT is both medium & long fatty acyl CoA. Therefore, we studied the ACAT enzyme, its active site, location and activity to develop the inhibitors of ACAT as antihyperlipidemic agents with the heterocyclic compounds for drug designing. ACAT is having two active sites: histidine and aspargines. ACAT 1 is present in two chromosomes 1 and 7. Active site His-460 Of ACAT-I is responsible for catalysis. For docking studies these factors should be known so that the hetercyclic compound could be developed having inhibitory activity against ACAT. Further many literature review have been done to find a hetercyclic moiety having the antihyperlipidemic activity in which we found that benzene ring with thiazole and oxazole rings having side chain could get...
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Posted by admin on Jun 30, 2022 in |
Medicinal plants provide numerous benefits to human health. Mussaenda frondosa Linn belongs to the Rubiaceae family, which has 500 genera and 5300 medicinal plant species. Mussaenda is a flowering plant genus with many beautiful species. Ayurveda, an ancient Indian healing system, describes many herbs, oils, and minerals. People have known about plants’ medicinal value since prehistoric times. Mussaenda contains many medicinal natural compounds such as steroids, triterpenes and flavonoids. The chief chemical constituent present in the whole plant is butanedioic acid, diethyl ester, caryophyllene, hexadecanoic acid, quinic acid, 4-((1E)-3-Hydroxy-1-propenyl)-2-methoxyphenol, Naphthalene, decahydro2-methoxy, 1, 2, 3-Benzenetriol, alkaloids, flavonoids, saponins and tannins. Mussaenda frondosa nanocomposite enhances bioavailability and therapeutic potential. The present review compiled data on the importance of plants and their treatment options. This paper will be very useful to those in the medical, therapeutic, pharmacognosy and pharmacology fields. This article examines the genus Mussaenda and its phytochemical and pharmacological properties....
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Posted by admin on Jun 30, 2022 in |
Xanthene (or 9H-xanthene) is a parent active compound in which a pyran ring is combined with a benzene ring on both sides, whereas in thioxanthene, the oxygen of xanthene is replaced by a sulphur atom. Xanthene and thioxanthene are important classes of organic compounds which exhibit diverse pharmacological activities such as anti-spasmodic, anti-parkinsonian, anti-psychotic, anti-rhinitic, anti-inflammatory, anti-asthmatic, anti-ulcer, etc. This review covers various methods of synthesis of Xanthene and Thioxanthene. The pharmacoeconomic consideration of various marketed products of Xanthene and Thioxanthene are also discussed. It also covers the ongoing clinical trials of the upcoming Xanthene and Thioxanthene-based products and the newer indication of existing drugs. This review would be of immense use to researchers interested in Xanthene and Thioxanthene-based drugs. This review also helps the physician to preferably prescribe the cheaper brand for the patient’s benefit with the help of pharmacoeconomic analysis discussed in the...
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Posted by admin on Jun 30, 2022 in |
The Greek words “angeion” (vessel) and “sperma” (seed) constitute angiosperm which together define enclosed seeds. The angiosperms differ from closely related gymnosperms in seed being naked and not enclosed within a fruit. Moreover, angiosperms are distinguished plants having colorful flowers. Having originated about 130 million years ago, the flowering plants are more diverse and largest among the prominent vegetation. While pteridosperms have been proposed as ancestors of angiosperms, they are the youngest and most recent group of plants having controversies over their origin and are still a hot topic of debate for botanists. Our present investigation is focused on valuing and conserving our beautiful but neglected bioresource that gets blown away or wiped out instead of conservation. From high mountain peaks to sea level and from desert to freshwater, almost all habitats are acquired by flowering plants. The present review signifies the importance of flowering plants in different medicinal aspects. The present literature reveals how researchers have worked on different concepts of flowering plants using petals of flowers as...
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