Posted by admin on Sep 30, 2022 in |
Curcumin is a highly potent, nontoxic, bioactive agent found in turmeric and has been known for centuries as a household remedy to many ailments. The main active ingredient of turmeric is curcumin, a polyphenol that helps prevent and control neurological, respiratory, cardiovascular, metabolic, inflammatory and autoimmune diseases and some cancers. The major drawbacks of curcumin are low absorption and poor bioavailability. Curcumin nanoparticles possess remarkable antibacterial, antiviral and antiprotozoan activity. Cancer is the second leading cause of death in the world and one of the significant public health problems. Despite the great advances in cancer therapy, cancer incidence and mortality rates remain high. This review mainly focuses on the preparation & methods of Curcumin nanoparticles and their applications. Therefore, the quest for more efficient and less toxic cancer treatment strategies is still at the forefront of current...
Read More
Posted by admin on Sep 30, 2022 in |
Quorum sensing is a peculiar mechanism of microbial communication through the induction of various signalling autoinducer molecules having several gene expression regulatory activities of different virulence factors that control microbial. This enables a systematic path of inhibiting microbial growth and its infection production efficacy by indirectly regulating the Quorum sensing activity of the concerned pathogens. As antimicrobial resistance directly impacts the healthcare system, hence is one of the biggest threats to global health. The attenuation or inactivation of these resistant variety bacteria is the utmost call of hour. In this panorama, interference/change in the chemical signal of QS system has been developed as an efficient technique to block their expression, hence enabling them as less virulent. A literature study was performed using online research, including database searches such as PubMed, SciELO, and SCOPUS between 2000-2020. This review aims to provide a brief mechanism of inhibition of microbial resistance through QS system by different...
Read More
Posted by admin on Sep 30, 2022 in |
Introduction: Long life, good health, and healthy development are all dependent on proper nutrition. Well-fed children do better in school, develop into healthy adults, and offer their children a better start in life. Undernutrition, on the other hand, remains a major issue, particularly among children who are deprived of adequate food in developing countries. Childhood undernutrition is an underlying cause of an estimated 35% of all deaths among children under five and 21% of total global disability-adjusted life years lost among less than 5 children. Pathological alterations in the body arise as a result of various diseases or excessive indulgence in factors leading to emaciation, resulting in the emergence of undernutrition. In such cases, Deepana–Pachana (appetizer and digestive) Brimhana (Increasing muscle bulk), and Rasayana (Rejuvenizing) therapy is needed. Methods: This review is conducted using a complete and organized search of the available literatures in Ayurveda texts and published articles. The searches were performed using various databases, including PubMed, Scopus, MedLine, Google Scholar, and others. The keywords used for the...
Read More
Posted by admin on Sep 30, 2022 in |
The scope for patients suffering from Autism Spectrum Disorder today is far brighter than what it was a century ago. A few of these individuals, after great efforts, can read, write and communicate reasonably well while living in their homes rather than support institutions. Nevertheless, a large segment of adults suffering from Autism cannot work full-time to earn their livelihood. To add to the misery, marriage and long-term relationships are out of reach for such patients. Autism Spectrum Disorder is now redefined as a constellation of symptoms manifested by defective social skills, impaired communication, stereotypical behavior and repetitive motor movements observed during early childhood. Although research in the area of childhood disorders has undergone an enormous development over the past 100 years, the etiology, pathogenesis, and biomarkers of Autism are still a matter of speculation. Autism research has witnessed blazing debates in recent years about the missed diagnosis and overlap of similar childhood disorders, which sometimes turned into academic rather than scientific face-offs. The Risk factors responsible for causing...
Read More
Posted by admin on Sep 30, 2022 in |
Background: Cancer is one of the deadly diseases, accounting for nearly 10 million deaths every year. Cancer is one of the leading dreadful conditions which most people. Cancer is may due to genetic change, which interferes with normal growth mechanisms. A mutant cell divides and produces abnormal masses. Cancer cells can break away from the mass (or tumour) and travel via the bloodstream or lymphatic system to different body parts. These cells can settle in other body parts to form secondary cancer or metastasis. Various approaches have been introduced to eradicate cancer. Objective: In this literature, we aim to study the In-silico molecular docking for Thiadiazole derivative with an anti-tumor receptor. Methodology: We have used Argus lab software for molecular docking. Ligand is prepared using Chemsketch software and proteins are prepared using Chimera software. Main Observation: our study shows that the binding value lies between -9.7 to -7, and hydrogen bonds are formed. Conclusion: Our study concludes that the Thiadiazole derivative forms good binding affinity with chosen receptors and...
Read More
