Posted by admin on May 31, 2022 in |
At a time where we understand that new drug discovery and development involves significant cost, expensive products and is the slow-paced process, an innovative idea called ‘Drug Repositioning’, which basically means repurposing of old drugs to treat diseases including both common and rare are being increasingly attractive as it provides drug development in a sustainable cost, time efficiently and the product value is also low, making it less risky for pharmaceutical investment. A drug initially marketed as an anti-anginal drug repurposed for erectile dysfunction (Sildenafil/ Viagra) is an important example of landmark evidence in history. Similarly, over the years, several drugs have been successfully repurposed into other drug uses to treat various diseases. In this systematic review article, we have focused on the wholesome idea and methodologies of drug repurposing and its approaches, methods, challenges and strategic advantages over traditional drug discovery in the present...
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Posted by admin on May 31, 2022 in |
Aegle marmelos, commonly known as Bael or Bilva, is a traditional tree belonging to the family Rutaceae with enormous value in ethnobotany, Ayurveda, and has been used since time immemorial for its spiritual significance as an offering to Lord Shiva while worshipping. Looking at its religious perspective and medicinal benefits, people have conserved trees of Bael in sacred groves. It is a sub-tropical tree and grows wildly in the dry, dry dipterocarp and mixed deciduous forests on the plains and hilly regions. Researchers have used and studied almost all the parts like root, bark, fruit, leaves, and seeds of this significant tree because of the varied phytoconstituents isolated from them, like alkaloids and terpenoids, amino acids, fatty acids, coumarins, etc. Substantial experiments were conducted on Aegle marmelos owing to many phytoconstituents found in it and they were found to exhibit potential therapeutic responses in many pharmacological activities like anti-diabetic, anti-hyperlipidemic, analgesic, antimicrobial, antipyretic, anti-inflammatory, radioprotective, anti-ulcer, anticancer, gastroprotective, antidiarrheal, etc., to name a few. Many pharmaceutical herbal industries have...
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Posted by admin on May 31, 2022 in |
Parkinson’s disease (PD), identified as the second most common neurodegenerative disorder, is a progressive disease that impairs the ability to control voluntary movements mainly. According to the findings of the pathogenesis of PD, lesions in dopaminergic innervation of the basal ganglia cause degeneration of neurons in the substantia nigra and thus leads to loss of striatal dopamine level. Hence, enhancement of dopaminergic transmission restores partial motor functions. In the current review, the possible in-vivo animal models have been described in detail, which mostly resembles the Parkinsonian state in humans and has helped research involving pathogenesis, treatment, and evaluating drugs having Anti-Parkinson activity. This study aims to set down all the possible models to screen agents that have a therapeutic or symptomatic role in treating Parkinson’s disease. Every model has its advantage and disadvantage, which must be carefully considered when choosing the model to be...
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Posted by admin on May 31, 2022 in |
In any nation’s public health care system, plants play an essential role in therapeutic treatment. The plant Thevetia peruviana is an evergreen ornamental dicotyledonous shrub belonging to the family Apocynaceae. Thevetia peruviana is widely distributed in Central and South America and Asian countries, especially in India and Srilanka. Alkaloids, flavonoids, steroids, terpenoids, tannins, saponins, cardiac glycosides, and other secondary metabolites are found in Thevetia peruviana. All parts of these plants are toxic and contain a variety of cardiac glycosides, including neriifolin, thevetin A, thevetin B, and oleandrin. The leaves of the plant are used as a cardiotonic and diuretic and are also reported to possess medicinal value in traditional systems of medicine. Several studies reported pharmacological activity in various plant parts, including seeds, flowers, bark, fruits and leaves. The purpose of this review is to provide the complete data, including morphology, cultivation and propagation, distribution, phytochemistry, traditional uses & pharmacological...
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Posted by admin on May 31, 2022 in |
Microsphere drug delivery is a novel drug delivery approach for sustaining and controlling the rate and release of active pharmaceutical ingredients. Microspheres are the choice of drug delivery for delivering the drug at a specific site to release the encapsulated drug to treat various diseases. Microspheres drug delivery is an attractive dosage form in terms of its flexibility and sustaining the release as compared to other sustained and controlled formulations. Most of the antihyperlipidemic drugs come under BCS class-II, which leads to poor solubility but higher permeability, the oral bioavailability of statins categories drug possess less bioavailability due to the poor solubility; hence microspheres are the best candidate for delivering antihyperlipidemic drugs to the systemic circulation and improving the systemic bioavailability of drug for a longer period with lesser adverse effects. Therefore microspheres can be used in various medical departments like oncology, gynecology, radiology, pulmonary, cardiology, diabetes, vaccine therapy, etc. this review article focuses on recent different methods of preparation. The microspheres formulated can be later evaluated and characterized...
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