Posted by admin on May 31, 2024 in |
Day by day it is challenging to prepare a chemical reagent against antimicrobial resistant pathogenic for pharmaceutical and food sector. There are several types of quantum dots are invented among them Sulfur Quantum Dots (SQDs) a new type of luminescent quantum dots which is prepared from unused sublimed sulfur can be replaced for these purposes. SQDs are highly water soluble, low toxicity and have an antimicrobial and antioxidant activity. There are several uses of this quantum dots, but in this review the synthesis method and their comparison, antibacterial and antifungal activity and antioxidant activity are described from its invention to present state. SQDs with packaging film exhibited effective antimicrobial effects especially against foodborne microorganisms caused by the production of reactive oxygen species (ROS). SQDs could be a potential agent for food packaging, disinfectant for fabric and increase the shelf life of...
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Posted by admin on May 31, 2024 in |
Levodopa suffers from low oral bioavailability and less than 1% of the drug reaches the brain because of its peripheral degradation. This study aimed to prepare a nasal in-situ gel of levodopa and carbidopa to provide prolonged drug release, improve bioavailability, and increase drug uptake by the brain. Preliminary studies were carried out using different polymers. The concentration of polymer to be employed for the development of the formulations was deduced by carrying out placebo studies (F1-F12). All the batches were assessed for various parameters such as pH, viscosity, gelation time, and mucoadhesive strength. Out of 12 placebos, F11 which is pH and ion dual activated in-situ formulation showed satisfactory results. Therefore, F11 formulation was selected to prepare levodopa and carbidopa nasal in-situ gel. Drug incorporated formulation was found to have a viscosity of 2870.13 cps, assay of 95.7% of levodopa and 100.83% of carbidopa, and gelation time of 35 s, and the in-vitro drug release of levodopa and carbidopa after 8 h is 95.7% and 99.38%, respectively. Ex-vivo...
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Posted by admin on May 31, 2024 in |
Artificial sweeteners are non-nutritive sugar substitutes designed to provide sweetness without the calorie content of sugar. Examples like Saccharin, Aspartame, Neotame Acesulfame K and they are used in producing a low- or no-calorie diet to lose weight. In the last few years, they have be used in most of the products. Now a days artificial sweeteners are used because they have no calories and pose no risk of obesity. It provides the detailed description of some of the artificial sweeteners and their history, uses and adverse effects. They are often used in food and beverages as alternatives to sugar, providing individuals pursuing to reduce their sugar intake. The artificial sweeteners have an important impact on people who have diabetes or overweight. Validation was performed to know the Linearity, Precision, Ruggedness, Robustness, Limit of detection, Limit of quantification. A simple method is used to determine the artificial sweeteners like saccharin and Aspartame based on UV visible spectrophotometric method and this article provides the analysis of Saccharin and Aspartame and including...
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Posted by admin on May 31, 2024 in |
Mucoadhesive buccal films have gained significant attention as a promising drug delivery system for various therapeutic applications. This review article provides a comprehensive overview of the recent advancements in mucoadhesive buccal films, focusing on their formulation strategies, mucoadhesive mechanisms and potential applications. The article discusses the various polymers used in the formulation of mucoadhesive buccal films, including natural, synthetic, and semi-synthetic polymers. The selection of appropriate polymers plays a crucial role in achieving optimal mucoadhesive properties and drug release characteristics. Furthermore, the influence of different formulation factors, such as plasticizers, penetration enhancers, and drug loading techniques, on the performance of buccal films is thoroughly examined. The discussion covers a wide range of topics, beginning with the structure and physiology of the buccal mucosa, which elucidates the particular properties that impact medication absorption. The complete examination of mucoadhesive polymers, nanoparticles, and thin film technologies is included in the comprehensive overview of formulation...
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Posted by admin on May 31, 2024 in |
Introduction: The increasing trends for caesarean section (CS) not only in India but also globally have been a cause of concern. With the aim of comparing and analyzing CS rates worldwide, the WHO suggests Robson’s ten group classification system (RTGCS). Aims and Objectives: To find the groups of women with high CS rate which will help policymakers to target that specific groups of women for the reduction of overall CS. Materials and Methods: This was a retrospective study design using hospital records for women delivered between January 1, 2021 and December 31, 2021. Data were entered and analyzed using Excel and presented in percentages after using RTGCS. Results: Out of total 12645 women delivered during the study period, 7180(56.78%) were delivered by CS. The high CS rates were in group 9 (abnormal lie) – 100%, group 6 (breech nulliparous) -94.73%, group 5 (previous CS) -93.67%. In respect of all CS, the maximum contribution was done by group 5 (31.03%), group 1 (23.90%) and group 10 (20.55%). Conclusions: The result...
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