Posted by admin on May 31, 2023 in |
This research primarily focuses on the process and impact of marketing authorizations, import, and export of COVID-19 vaccines in India and the United States. Pharmaceutical firms now have great legal grounds in India and the United States for vaccine manufacture and distribution. In this pandemic, the regulatory authority of India CDSCO and the US FDA updated the guidelines to provide approval for vaccines in less than a month through emergency use authorization. The Indian medical regulatory system and the USFDA have made it easier for COVID-19 vaccines to obtain clearance for commercialization. These new rules have made pharmaceutical companies easily get their vaccines to users. In today’s competitive world, shortening the time to launch a product is considered to company’s success. All pharmaceutical manufacturers/importers, regulatory, preclinical, formulation scientists, and clinical trial professionals who are directly or indirectly engaged in the covid-19 registration process will benefit from this study. We require expertise and broad views to properly handle the regulatory process for vaccination licensure in India and the United States...
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Posted by admin on May 31, 2023 in |
Grapes are one of the most widely grown fruits and have been used for winemaking since the ancient Greek and Roman civilizations. Grapes are rich in proanthocyanidins which have been shown to possess potent free radical scavenging activity. Grape seeds are a complex matrix containing 40% fiber, 16% oil, 11% proteins, and 7% complex phenols such as tannins, in addition to abundant quantities of gallic acid, p-coumaric, caffeic and ferulic acids etc. also present. Roots contain resveratrol, vitisins A & B and other stilbenoid compounds. Leaves of grapes include gallocatechin, catechins, procyanidins, epicatechins, hydroxybenzoic acid, syringic acid and coumarin. Grapes are rich sources of flavonoids and contain monomers, dimers, trimers, oligomers and polymers. The monomeric compounds includes (+)-catechins, (-)-epicatechin, and epicatechin-3-O-gallate. Grapes have pharmacological activities, like anti-inflammatory, antidiabetic, antioxidant, anti-aging, anti-cataract, antibacterial, antifungal, antiacne, antiobesity, antispasmodic, spasmolytic, anti-virus, wound-healing, antihypertension and antiplatelet and antihyperpigmentation. Studies have reported that grapefruit exhibit a broad spectrum of pharmacological properties against Alzheimer, tumor, leishmanial, Low-Density Lipoprotein, viral, oxidative stress, and had hepatoprotective activity....
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Posted by admin on May 31, 2023 in |
Isatin (1H-indole-2,3-dione) and its derivatives represent an important class of heterocyclic compounds that can be used as precursors for drug production. Erdmann1 and Laurent2 first discovered isatin in 1840 as an oxidation product of indigo dye for nitric acid and chromic acid. Isatin is one of the most important heterocyclic compounds. For example, Schiff foundations of isatin are used for their medicinal properties. This review understands a variety of synthetic methods in particular, sandmeyer synthesis, stolle synthesis, and gassman synthesis isatin synthesis. This review reports some of the biological applications of Isatin derivatives such as anticancer, antiviral, antifungal, antioxidant, etc. From these studies, Isatin was established as a promising candidate for further research and investigation in a number of...
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Posted by admin on May 31, 2023 in |
An Antibiotic is an infectious disease that is the chief source for treating bacterial & fungal infections. The microbial resistance problem has been increasing daily, and the viewpoint for the usage of antimicrobial drugs is still undefined. Antimicrobial-resistant organisms are found in people, animals, food, plants, and in the environment. Do not use antibiotics to treat viral infections like colds and flu. The leading mechanism for spreading the resistance of antibiotics over bacterial populace is plasmids. Biofilm formation decreases the penetration of antifungal compounds into the population. According to World Health Organization (WHO) medicinal plants would be the best source to attain a variety of drugs. 80% of people from developed countries use traditional medicine derived from medicinal plants. Using plant extracts and phytochemicals with identified antimicrobial properties can be greatly useful in treatments. Several plants rich in a wide variety of secondary metabolites, such as tannins, alkaloids, and flavonoids, have been used for their antimicrobial qualities. They can spread from person to person or between people and animals,...
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Posted by admin on May 31, 2023 in |
Antibacterial activity of methanolic extracts of different parts (leaves, flowers, green pods and roots) of Moringa oleifera plant were evaluated against gram positive bacteria Bacillus subtilis (Bs), Staphylococcus aureus (Sa) and gram negative bacteria Klebsiella pneumonia (Kp), Escherichia coli (Ec), Pseudomonas aeruginosa (Pa). The activities were performed by the agar well diffusion and cup plate method, with methanol as the negative and tetracycline as a positive control. Secondary metabolites extracted from all the parts of M. oleifera were found active against bacteria. Furthermore, the antimicrobial activity of the mentioned plant extracts was also examined against various gram-positive and gram-negative bacterial strains. It was observed that against K. pneumonia, leaves extracts (17.6 mm) of M. oleifera possess higher antibacterial activity as compared to others, flower extract (19.2mm) against B. subtilis, leaves extracts (22.6 mm) more effective against E. coli, pod extracts (22.5 mm) against S. aureus and leaf extract (21.9 mm) showed against P. aeruginosa as compared to others. The results reveal that M. oleifera might be a potential source...
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