Posted by admin on May 31, 2021 in |
The constant increase in the emergence of multidrug resistance among Staphylococcus aureus strains threatens public health. The study aimed at evaluating the anti-S. aureus activity, pharmacokinetic properties and interactions of compounds from Erianthemum dregei with proteins in S. aureus. Anti-S. aureus activity was investigated by broth dilution method while gas chromatography-mass spectrometry (GC-MS) was used to identify the compounds. The drug-likeness, pharmacokinetic and toxicity profiles of the compounds were predicted by SwissADME and PreADMET tools. AutoDock Vina was used to assessing the binding affinities of the docked ligand-receptor complexes. The extract revealed the minimum inhibitory concentration value of 0.78 mg/mL. Phytol (93.58%) and 3-tetradecyn-1-ol (6.42%) were the revealed constituents. In-silico predictions suggested both compounds to have drug-like properties as they adhered to the Lipinski’s rule of five. Phytol was found to have non-mutagenic effects, while 3-tetradecyn-1-ol was predicted to be mutagenic. The compounds were non-carcinogenic on mice model and carcinogenic on rat`s. Phytol has a binding affinity to DNA-gyrase and FtsZ with docking energy values of -4.1 and -5.3...
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Posted by admin on May 31, 2021 in |
Osteoporosis is a condition that makes the bones porous, fragile, and prone to fractures. Although it is very prevalent in elderly people, it is more common in women, especially after menopause. The present study aimed to evaluate the effect of Asthiposhak Tablets on their anti-osteoporotic activity in ovariectomized (OVX) rats. Thirty-two female albino Wistar rats were randomly divided into four groups (n=8). Group 1 served as sham-operated control. Group 2 rats were ovariectomized (OVX) and served as a negative control. Group 3 received raloxifene (5.4 mg/kg i.p.) and served as the standard control, and Group 4 received Asthiposhak (405 mg/kg p.o.) and served as treatment control. After 60 days of ovariectomy, animals were treated with Asthiposhak for the next 45 days. At the end of the study, femur bone length, weight, bone ash calcium level, and bone mineral density (BMD) were estimated. The levels of serum alkaline phosphatase (ALP), calcium, and phosphorous, and bone histopathology were also evaluated. OVX-induced increased serum ALP, calcium, and phosphorous levels were significantly attenuated...
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Posted by admin on May 31, 2021 in |
Though the anesthesia-related death of a 15-year-old Hannah Greener marked the beginning of pharmacovigilance 160 years ago, the science of pharmacovigilance was not established as a separate field until the wake of the thalidomide tragedy in 1960’s. The World Health Organization (WHO) instituted International Drug Monitoring Program to internationalize the act of drug safety monitoring. Inspite of this, many countries, particularly the low and middle-income developing countries, found it difficult to implement a robust drug safety monitoring system in their country due to various technical and financial snags. India was able to establish its own pharmacovigilance system called Pharmacovigilance Program of India (PVPI) only in 2005. This article analyzes the hurdles and challenges faced by India during the implementation phase of the Pharmacovigilance program, and this article also compares the pharmacovigilance system of India with few other developed and developing...
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Posted by admin on May 31, 2021 in |
Controlled and targeted drug delivery system is more advantages than conventional dosage in various aspects. In the case of treating colonic disorders such as inflammatory bowel disease, the drugs do not reach the site of action in appropriate concentration. Thus there is a need to develop effective and safe therapy for the treatment of these colonic disorders, using site-specific drug delivery approach. The present study was aimed to develop microbially triggered osmotic pump so as to achieve colon specific delivery of dexamethasone. The microbially triggered colon-targeted osmotic pump (MTCT-OP) based tablets are prepared by using two types of polymers chitosan and pectin. The tablet is formulated by using directly compressible method, which consists of an osmotic core (drug and chitosan with organic acid as excipient) and (drug and pectin with organic acid as excipient) with an inner semi-permeable membrane layer composed of the mixture of cellulose acetate and chitosan powder and an outer enteric-coating layer of eudragit® L100-55. Then a comparative study of this formulation was done. It was...
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Posted by admin on May 31, 2021 in |
India is a great source of naturally occurring plant drugs which are having potential pharmacological activities. Origanum vulgare L. (Lamiaceae) is one of the most important medicinal plants in India, consisting of aromatic and medicinal properties which is used to cure many ailments. In spite of its plethora of uses as medicine and food additives since ancient times, it has reaped very little scientific interest so far, particularly in India. In such a propitious context, the intention of this study was to enhance the plant as a medicinal herb by determining pharmacognostic standards and evaluating the phytochemical components. Hence, the present study aimed at the pharmacognostical standardization of Origanum vulgare L., including the morphology, anatomy, and powder studies pertaining to organoleptic, microscopic, and physical constant evaluations. This study also describes the phyto-chemical screening and HPTLC analysis of major phytochemicals present in the taxa. The pharmacognostic profile obtained from this work can serve as a tool for developing standards for the identification, quality, and purity of Origanum vulgare L. The...
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