Posted by admin on May 31, 2020 in |
Diet and dietary habits of an individual are considered to be an essential factor based on biologically active compounds extracted or modified from either known or unknown natural sources, contributing to completing the dietary and nutritional needs beyond the traditional supplements. Moreover, the latest research information about their supportive and therapeutic utility suggests that they play a potential role in promoting the overall sensory and motor synergies in the brain, reducing cognitive decline and activating neuronal receptors. Many of the functional food items are reported to have many effective bioactive compounds such as – polyphenols, flavonoids, stilbenes, terpenoids, carotenoids, alkaloids, omega 3, PUFA, etc. Also, various phyto-compounds (ginseng, vitamin B12, alpha-lipoic acid, berry anthocyanins, trans-resveratrol, Ginkgo biloba, Bacopa monniera, Huperzine A, Centenella asiatica, vinpocetine, tocotrienols and palm oil, selenium) are noted globally for incrementing the cerebral health and its upkeep, listed as functional foods. This review study focuses on the direct co-relation and various effects of functional foods in reducing or preventing the neurodegeneration process. Authors have also summarized...
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Posted by admin on May 31, 2020 in |
Multiparticulates consist of discrete, small, multiple unit systems of active pharmaceutical ingredients exhibiting the desired drug release pattern. The present work is concerned with the formulation and evaluation of a pH-dependent multiparticulate colon targeted drug delivery system of ketoprofen, a well established anti-inflammatory drug used in the management of inflammatory bowel disease. The reason for carrying out this study was to release the drug at a targeted site of the large intestinal region of the gastrointestinal tract on the basis of pH variability and to improve patient compliance. The drug-loaded pellets were fabricated using powder layering technology and thereafter pH-dependent multiparticulates were prepared by employing a mix polymeric coating of pH-dependent Eudragit S100 and Eudragit L100 polymers over the drug-loaded pellets. Different ratios of these pH-dependent polymers were used in the formulations of the coated drug-loaded pellets. The developed pellets were assessed for technical parameters such as drug entrapment efficiency, in-vitro dissolution study, scanning electron microscopy, FTIR, and DSC study. The in-vitro release kinetics reveals that the optimum formulation...
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Posted by admin on May 31, 2020 in |
A simple, rapid, accurate, precise, and reproducible stability indicating RP-HPLC method for the estimation of Inotuzumab Ozogamicin in bulk and injection dosage form was developed and validated as per ICH guidelines. The separation was done using BDS C18 150 × 4.6 mm, 5 µ column. The mobile phase (Water and Acetonitrile 55:45% v/v) was pumped at 1.0 ml/min, and effluent was detected at 240 nm using a PDA detector. The retention time was 2.93 ± 0.1 min, and the method produced a linear response in the concentration range of 4.5-27 µg/ml (r2– 0.9995). In recovery studies, %RSD from reproducibility was found to be below 2%. LOD and LOQ were 0.1 µg/ml and 0.34 µg/ml, respectively. The drug was subjected to different stress conditions such as acidic, alkaline, oxidative, photothermal, and hydrolysis. The drug showed more degradation in acidic conditions, and no degradation was observed in hydrolysis and photo conditions. The developed RP-HPLC method was found to be effective, sensitive, and specific for the estimation of Inotuzumab Ozogamicin in bulk...
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Posted by admin on May 31, 2020 in |
Verapamil hydrochloride is a water-soluble drug, so it is suitable to develop controlled porosity osmotic pump. As Verapamil HCl is a short-acting drug, so developed formulation provides the advantages of controlled release formulations. The developed formulation provides advantages of less steps of manufacturing procedure, no need for laser drilling, and economical, all of which made the procedure easily amenable to mass production using conventional tablet machines. Verapamil HCl 120 mg core formulations were prepared coated with film former (cellulose acetate): pore former (sorbitol). The effect of different formulation variables, namely, membrane weight gain, and amount of pore former in the membrane, were studied. Verapamil HCl release was inversely proportional to the membrane weight (coating thickness) but directly related to the initial amount of pore former (sorbitol) in the membrane. Drug release from the developed formulations was independent of pH but dependent on the osmotic pressure of the release medium. Verapamil HCl release from the developed formulation follows zero-order. The drug release from formulation was proved as dependent on osmotic...
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Posted by admin on May 31, 2020 in |
A glycyrrhetinic acid isolated from herbal plant Glycyrrhiza glabra (family Fabaceae), commonly known as licorice is used to formulate microemulsion as a self-emulsifying drug delivery system for oral administration using almond oil as the oil phase. Pseudoternary phase diagrams were constructed to determine the microemulsion existence region using surfactant (Tween 80) and co-surfactant (propylene glycol). Different formulations in the form of microemulsions were prepared to evaluate the effect of oil content, surfactant/co-surfactant concentration on in-vitro diffusion rates. In-vitro drug diffusion of glycyrrhetinic acid from the microemulsions was evaluated using the dialysis membrane. The amount of glycyrrhetinic acid permeated was analyzed by using the UV method. The permeability of the glycyrrhetinic acid incorporated into the microemulsion systems was considerably increased than that of the plain drug. These results indicate that the microemulsion system studied is a promising tool for increasing the solubility and oral absorption of glycyrrhetinic...
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