Posted by admin on May 31, 2020 in |
From bench to bedside, clinical research had always played as a convenient tool in the field of cancer biology to inquire about the effectiveness of different anticancer drugs on different human-derived cancer cell lines. According to the American Cancer Society, nearly 4000 new cases and 1600 deaths predicted in 2019 in the United States. Besides, to these alarming statistics, rising cost and health-related complications associated with treatments had made the research of cell lines on the anticancer drug more relevant. This article providing a comprehensive review of cancer, advanced development of the anticancer drugs, and a brief inference on progression-free survival rate (PFS) of the following anticancer and engineered monoclonal antibody drugs are...
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Posted by admin on May 31, 2020 in |
The present research work was envisaged to develop immediate release film-coated tablets of a fixed-dose combination of Atorvastatin calcium and Amlodipine besylate used to treat the hyperlipidemia, angina pectoris, atherosclerosis, hypertension and symptoms of cardiac risk. Additionally, fixed-dose combination therapy of both drugs tends to provide a synergetic effect and reduce the pill burden. Immediate-release tablets are mostly recommended for fast upgrading drug delivery systems, and thus, an effort was made to improve the onset of action of the drug. The concept of formulating immediate-release tablets using superdisintegrants like CCS offers a suitable and practical approach to faster disintegration and dissolution characteristics. In the current investigation two methods were adopted namely direct compression and wet granulation for formulation development. Based on the drug content and dissolution results, the direct compression method was used for further study. The prepared dosage forms were also subjected to pre and post compression evaluations. The results of in-vitro drug release suggested that CF6 was the ideal formulation among all the other formulations. In-vitro drug...
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Posted by admin on May 31, 2020 in |
The aim of the present work is to determine the feasibility of peracetic acid (PAA) and the coexistent hydrogen peroxide (HP) simultaneous quantitative determination in disinfectant solution by voltammetry using carbositall rotation electrode (CE) as indicating electrode. It has been experimentally proved that the optimum pH for analysis is approximately 3.6. The linear relationship has been observed in the PAA concentration range (3.12–12.50)´10–5 mol L–1, the calibration curve equation was Iр = (3.78 ± 0.46)´103с (r = 0.995); in the HP concentration range of (0.94–3.76)´10–4 mol L–1, the calibration curve equation was Iр = (3.57 ± 0.26)´103с + (0.11 ± 0.07) (r = 0.998). Determining PAA in the working solution with the concentrations of 6.24´10–5, 7.80´10–5 and 9.36´10–5 mol L–1 the RSDs were 0.035, 0.028 and 0.022 respectively (δ = +0.30…+0.90%), determining HP in the working solution with the concentrations of 1.88´10–4, 2.35´10–4 and 2.82´10–4 mol L–1 the RSDs were 0.028, 0.018 and 0.011 respectively (δ = –0.77…+0.92%). Determining PAA in the test solution of “Delakson” disinfectant with the concentrations of 0.1%, the RSD...
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Posted by admin on May 31, 2020 in |
Present work was aimed to determine, identify, and characterize the bioactive chemical compounds from methanolic leaves extract of Abutilon fruticosum by GC-MS analysis. Fresh disease-free leaves were collected shade dried and powdered for extraction with HPLC grade methanol. Preliminary phytochemical screening of methanolic leaves extract was performed using standard methods to determine the presence of different chemical compounds; the crude extract was subjected to GC- MS analysis for the identification of bioactive compounds. Phytochemical screening of methanolic leaves extracts revealed the presence of carbohydrates, proteins, alkaloids, phenols, flavonoids, terpenes, phytosterols, etc. Furthermore, GC MS analysis of the extract revealed the presence of 65 bioactive compounds. Some major biologically active compounds identified were Azulene (24.91%), Hexadecanoic acid (13.27%), Phytol (9.51%), Beta-sitosterol (3.19%), Lupeol (1.21%), Campesterol (0.33%) etc. These chemical compounds are biologically active and pharmacologically important. The study provides detailed information about the identification and chemical characterization of various medicinally important phytocompounds from methanolic leaves extract of this plant. Although the plant is rare and endemic to Indian Thar Desert...
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Posted by admin on May 31, 2020 in |
Doxorubicin (DOX), an anthracycline antibiotic that is highly used for cancer treatment (chemotherapy), but its chemotherapeutic application is limited due to its cardiotoxicity. The major mechanism of doxorubicin action as the free radical formation and as an inhibiter of topoisomerase II and other signaling pathways is also invoked significant consequence for the cardiomyocyte. But the years of clinical use of doxorubicin generates a need for monitoring the procedure of cardiotoxicity as well as understanding its potential. Peak plasma concentration plays a key role in causing cardiotoxicity and antineoplastic activity. There are two mechanisms, the first one is anti-tumor action, and second one is cardiotoxicity. Cardiotoxicity mechanism has several pathways 1) formation of reactive oxygen and nitrogen species 2) interaction of calcium overload 3) disturb the serum biomarker levels 4) DNA damage. These are the main pathways to cause cardiotoxicity. Some signs and symptoms are given to identify doxorubicin cardiotoxicity like echocardiographical changes, angiographic changes, and disturbance in the serum biomarkers level like GSH, LDH and CK-MB. Some drugs are...
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