Posted by admin on May 12, 2019 in |
In the present work, we have measured natural radioactivity in twelve building materials samples for four kinds (Brick, cement, gypsum and sand) obtained from some Iraqi governorates by using High Purity Germanium (HPGe) radiation detectors system. The results of measurements have shown that the average values specific activity concentrations for 238U, 232Th and 40K which were equal to (24.236 ± 4.4 Bq/kg), (26.394 ± 4.0 Bq/kg) and (174.888 ± 29.1 Bq/kg), respectively., which were lesser than the corresponding recommended global values reported by (UNSCEAR, 2000) publication. The radiation hazard indices [Raeq DƔ, (AED)in, (AED)out, Hin and Hex] were also studied. The obtained results were also found to be lesser than the allowed limits given by (UNSCEAR, 2000). Thus, all results obtained in the present work have shown no significant radiological hazard when the studied building materials is used for construction of...
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Posted by admin on Jun 5, 2018 in |
Coumarin segment have been reported broad spectrum of different biological activities with the oxazine derivatives. In view that we have synthesized newer coumarin clubbed 4-(4-fluorophenyl)-6-substituted phenyl-2H-1,3-oxazin-2-amine and screened for their biological studies. 4-(4-fluorophenyl)-6-substituted phenyl-2H-1,3-oxazin-2-amine IIa-j condensed with 4-Methyl-6-nitro-2-oxo-2H-chromen-7-yl chloro acetate 5 to afford 4-Methyl-6-nitro-2-oxo-2H-chromen-7-yl-2-(4-(4-sustitutedphenyl) oxazine – 2- yl – amino) acetates 2a-j. The newer compounds were characterized by IR, NMR and mass spectral studies and were screened for their antimicrobial, antitubercular and antioxidant activities. Compound 2a (-C6H5) 62.5 µg/ml, 2d (2-OH) 100 µg/ml against S. aureus, 2a (-C6H5) 50 µg/ml, 2f (4-F) and 2j (3-OPh) 100 µg/ml against S. pyogenes as compared to chloramphenicol and the other compound 2c (4-Cl) showed excellent potency 25 µg/ml against E. coli and 12.5 µg/ml against P. aeruginosa while compound 2e (4-OH) exhibited comparable activity of 62.5 µg/ml and 100 µg/ml against E. coli and P. areuginosa respectively. Furthermore 2i (3-Br) also showed 100 µg/ml moderate potency against E. coli compared to the standard drugs chloramphenicol and ciprofloxacin. The study of antifungal activity...
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Posted by admin on Jun 1, 2018 in |
By considering the current regulatory requirement for an analytical method development, a reversed phase high performance liquid chromatographic method for routine analysis of cobicistat has been developed using analytical Quality by design approach. The optimized method was achieved using unisol C-18 (3 μm, 4.6 ×150 mm) column with mobile phase consisting of mixture of water and methanol (70: 30 v/v) with a flow rate of 1ml/min at 240 nm. The optimized method was then validated according to the ICH guidelines. The developed method was found linear over the concentration range of 10-80 μg/ml and the detection and quantitation limit was found to be 0.39μg/ml and 1.2μg/ml. There are no interfering peaks under performed degradation conditions. Therefore, a sensitive, robust, accurate and stability indicating method was developed with high degree of practical...
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Posted by admin on Jun 1, 2018 in |
Renal stones disease is the most common disease of the urinary tract affecting about 10% of the global population. Renal stone disease is a common disorder that develops when the urine becomes overly saturated with certain microscopic substances that bind into hardened mineral deposits known as renal stones. The objective of our current study is to evaluate the total organic acids of urine of calcium oxalate stone formers and compare it with that of non stone formers, to investigate whether the difference between the property studied in two groups really exists or not. The study was conducted on 50 patients divided into two groups- Group I consist of 25 idiopathic patients having calcium oxalate renal stone i.e. stone formers (SF) and Group II consists of 25 controls i.e. non stone formers (NSF) having no clinical evidence of renal stones. Each patient and control collected a 24 h urine, which was kept unrefrigerated, using thymol as preservative. It was found from our studies that evaluation of Total organic acids can...
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Posted by admin on Jun 1, 2018 in |
The mineral Srotonjana (antimony sulfide) is being used by Indians since ancient times. In Ayurvedic texts, it has been directed that Srotonjana should be used only after shodhana. Shodhana is a process to remove the unwanted physical, chemical impurities and toxic material and makes it suitable for medicinal use. Metallography is an advanced scientific study which is used in the study of the microstructure and identification of the parent metal particles along with the nature of compound formed during the shodhana. The difficulty of low solubility and less dissolution rate of metal and minerals has received broad academic and industrial awareness. So the aim of present study was to generate metallographic and solubility in the different solvent study as a tool (fingerprint) for ashodhita and shodhita Srotonjana for quality assessment and standardization. In the present study, Srotonjana was shodhit by seven bhavana (levigation) with bhringraj swaras and with triphala kwath. The finding results revealed that after shodhana Srotonjana broke into smaller particles and became homogeneous in both shodhit the...
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