Posted by admin on May 31, 2024 in |
Schedule Y has been established under Drugs and Cosmetic Act 1940 and rule 1945 for the conduction of clinical trials. It is referred to fundamentals and guidelines for import and manufacture of original drugs for trade or for clinical trials. Schedule Y provides guidance for conducting various clinical trials in different fields of clinical research, controlling and regulating any new drug prior to their entry into the market. It includes the responsibilities of key authorities such as sponsors, investigators, and ethics committee) and year wise evolutions, as well as the evolution of these guidelines over the years as the review present (sponsor, investigator and ethics committee) and year wise evolution suggested by various authorities. In addition, different phase of clinical trials with their respective roles. This updated study demonstrates the Indian government’s strong commitment to the conduct of trials in India and safeguarding the interests of human subjects. The Suggestive consolidations for improving clinical trials may contribute significantly to strike balance between the interest of the subjects and the growth...
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Posted by admin on May 31, 2024 in |
Background: Self-medication is of particular concern as the trend is increasing now-a-days, especially during the post COVID-19 pandemic. Without adequate knowledge, self-medication may lead to adverse drug reactions, or in extreme cases, may require hospitalization for further management. Methods: A questionnaire-based cross-sectional study was undertaken involving the dental undergraduate students in a private dental college in Haryana after it was validated. 150 dental students filled the questionnaire within the age group of 17-25 years. Results: In the present study, the data has been obtained from self-medication questionnaire. Out of 150 students, the females were 106 (71%) and the males were 44 (29%). Our study showed that 91% of the students practice self-medication. Females practiced more self-medication (96.23%) than male students (79.54%). The most common reason for self-medication were previous visit to the doctor, medicines present at home of the previous visit, to save time, to avoid visit to the OPD/doctor and to save expenses. The sources of drug information which the students preferred were from the pharmacy (37.3%). Paracetamol...
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Posted by admin on May 31, 2024 in |
Livamurtha, traditional polyherbal formulation possess hepato-protective, antibacterial, and antihepatotoxic properties used for treating liver disorders. This exploratory study was designed to evaluate the acute and sub acute toxicity effects of traditional formulation in albino mice based on the OECD Guidelines. 10g of formulation ”Livamurtha” was boiled in 500ml of water for 1 hour. The decocation (Filtrate) obtained was evaporated and later were reconstituted in water for further analysis. In acute toxicity study, healthy albino mice were chosen for study with starting single dose of 5mg/kg/body weight followed by single doses of 50,300 and 2000mg/Kg/body weight in separate group of each 3 animals. The animals were observed for 14 days and its physical activities were noted. In sub toxicity study, the aqueous extract of formulation was administered orally at repeated dose of 300 and 600 mg/kg body weight for 28 days. The animals were sacrificed on the 29th day for further haematological, biochemical and histopathological examinations were done. In acute toxicity, no behavioural changes, mortality and toxicity was observed in...
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Posted by admin on May 31, 2024 in |
Psychopathy is associate rising health issue in current times. In recent years, there has been increasing acknowledgement of mental state that plays a very important role in achieving international development goals. Several health conditions will be effectively treated at comparatively low price, however the gap between individuals needing care and people with access to worry stay substantial. This analysis has been conducted to work out the angle of pharmacy professionals towards psychopathy and insane persons (mentally ill) by mistreatment the BMI (Beliefs towards Mental Illness) scale. The BMI scale was designed to live such beliefs also on predict the requirement of study regarding mental state and health problem. The percentage of each subscale which shows the significant knowledge towards mentally ill persons and their treatment seeking behavior is based on the assumption of higher obtainable score of the total participants. The percentages of the subscale were found. Dangerousness = 51.59%. Poor social and interpersonal skill = 43.22%. Incurability = 49.81%. The negative beliefs/notions towards mentally ill people were found...
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Posted by admin on May 31, 2024 in |
The objective was to determine the effect of calcium phosphate composite with doxycycline molecularly included as a graft on bone defect after tooth extraction for slow delivery of drug. Methods: animal were distributed in to four groups: Group 1 (Blood Clot), Group 2 (TCP), Group 3 (TCP/PCL/PLGA), and Group 4 (TCP/PCL/ PLGA/ DOX/CD). An alveolar bone defect was created, and the analysis was conducted at preset intervals of T1 (14 days) and T2 (28 days). Results: The results of the histological study using H&E staining demonstrated the existence of newly created bone in all experimental groups. Group 4 exhibited the biggest area of newly formed bone at T1, and this observation was consistent across all time points examined. Group 4 exhibited a consistent volume across the measured time intervals, as evidenced by the existence of more advanced and structured trabeculated bone in T2 in comparison to T1. Even more Group 4, notably T2, displayed the highest proportion (47%) of newly formed bone area in comparison to Group 1 (36%),...
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