Posted by admin on Aug 15, 2010 in |
The solubility behavior of drugs remains one of the most challenging aspects in the formulation development. Although there was a great interest in solid dispersion systems during the past four decades to increase solubility by improving dissolution rate and bioavailability of poorly soluble drugs; there commercial use has been very limited, primarily because of manufacturing difficulties and various stability problems. It can be carried out by reducing drug particle size to the absolute minimum, and hence improving drug wet-ability, bioavailability may be significantly improved. Solid dispersion of drugs was generally produced by melt or solvent evaporation methods. Recently, surfactants have been included to stabilize the formulations, thus avoiding drug recrystallization and potentiating their solubility. New manufacturing processes to obtain solid dispersions have also been developed to reduce the drawbacks of the initial process. In this review, it is intended to discuss the eminent approach to improve the solubility or the dissolution rate and recent revival has been...
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Posted by admin on Aug 15, 2010 in |
Carvedilol is used for hypertension, angina pectoris and in symptomatic heart failure. It has a short half life of 2h and bioavailability of 25%. Therefore the present investigation is concerned with the development of the buco-mucoadhesive films, which were designed to prolong the buccal residence time, to increase penetration through buccal mucosa and thus increase the bioavailability and its half life. Various formulations were developed by using release rate controlling film forming polymers like Eudragit RL-100, PVP, HPMC, NaCMC and Carbopol 934 in various combinations by solvent casting technique using plasticizer propylene glycol with and without penetration enhancers like DMSO, Tween 60 and castor oil. For unidirectional release, backing layer using ethyl cellulose 10%w/v in ethanol incorporated with propylene glycol as a plasticizer was casted on the films. The most satisfactory formulations had retained on buccal cavity for maximum duration of 10h, released for longer duration of dissolution beyond 12h which had maximum drug permeated during ex-vivo studies. During ex-vivo diffusion studies contributed formulation consisting DMSO as penetration enhancer...
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Posted by admin on Aug 15, 2010 in |
A simple, accurate, cost effective and reproducible spectrophotometric method has been developed for the estimation of Diphenhydramine Hydrochloride in soft gelatin capsule dosage form. For UV spectrophotometric method, maximum absorption was found at λmax 258nm.The percentage recovery of Diphenhydramine Hydrochloride ranged from (98.97 ± 0.2989) in capsule dosage form. The developed method was validated as per ICH guidelines with respect to linearity, accuracy (recovery), precision and specificity. Beers law was obeyed in the concentration range of 10-100μg/ml having line equation y = 0.016x – 0.018 with correlation coefficient of 0.9934. By treating the data statistically and by recovery study, results of study were...
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Posted by admin on Aug 15, 2010 in |
In this study, the anti-inflammatory effect of methanolic extract obtained from root tubers of plant Curculigo orchioides Gaertn. (Amaryllidaceae) was investigated. The effect of extract was studied in Carrageenan induced rat paw oedema. The extract at a dose of 200mg/kg and 400mg/kg was carried out for the investigation. The results indicate that methanolic extract, at the dose of 200mg/kg & 400mg/kg was found to have statically significant anti-inflammatory activity as compare to control. The percentage inhibition of inflammation was found higher at the dose of 400mg/kg body weight at 3rd hr as compare to 200mg/kg.The activity was compared with that of the standard drug, Diclofenac sodium (15mg/kg)....
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Posted by admin on Aug 15, 2010 in |
Despite recent success, many fast-dissolving tablets (FDTs) still face problems of low mechanical strength, poor mouth-feel, higher wetting and disintegration times. This research work aimed to overcome from these drawbacks. Attempts were made to prepare fast dissolving tablets by employing vacuum drying technique utilizing single and multi-volatile components. Analysis revealed that, formulation containing camphor and menthol as subliming agents yielded the best result in terms of dissolution rate (M7). Results also revealed that, all the formulations had enough mechanical strength, good mouth-feel and lesser wetting and disintegration time. Stability study indicates that upon storage disintegration and wetting time of tablets decreased significantly without losing their mechanical strength....
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