Posted by admin on May 1, 2014 in |
Hair loss problems can affect physical and mental health of human and have particular relevance during the aging process. In an effort to find solution of such problems, an attempt has been made to evaluate the hair growth promotion activity of a herbo-mineral Ayurvedic formulation, Trichup Tablet. Safety of drug was also evaluated by conducting acute toxicity study as per OECD guideline. For evaluation of hair growth promoting activity selected animals were divided in to three groups where each group was consisting of six animals. TED and TED×2 group was treated with Trichup Tablet at 198 mg/kg/day and 396 mg/kg/day, p.o., for 30 days respectively. Visual parameters, hair length, hair diameter and serum total protein were determined. The animals did not manifest any signs of toxicity or mortality. Treatment of Trichup Tablet showed significant effect on all visual parameters. Length and diameter of hairs were significantly increased in TED and TED×2. Serum total protein was also observed to be elevated in TED and TED×2 in comparison to normal control....
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Posted by admin on Dec 10, 2010 in |
Asthma is disease of the human respiratory system in which the airways constrict and become narrow, often in response to a “trigger” such as exposure to an allergen, cold air, exercise or emotional stress. Due to rapid industrialization and urbanization, asthma prevalence is predicted to increase more rapidly in the coming years. Despite the availability of a wide range of drugs for the treatment of asthma, the relief offered by them is mainly symptomatic and short lived. Moreover the side effects of these drugs are also quite disturbing. Medicinal plants have been known for millennia and are highly esteemed all over the world as a rich source of therapeutic agents for the prevention of diseases and ailments. The importance of herbal medicine in the treatment of asthma is indisputable. Four of the five classes of drugs currently used to treat asthma namely; β2-agonists, anticholinergics, methylxanthines and cromones have origins in herbal treatments going back at least 5000 years. In the present article an attempt has been made to review...
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Posted by admin on Dec 1, 2010 in |
A simple and sensitive liquid chromatography–tandem mass spectrometry method was developed and validated for estimation of Labetalol in human plasma, an adrenergic β-receptor blocking agent used in the treatment of hypertension, which exhibits both α- and β-adrenoreceptor blocking activity. The analyte and internal standard (Metoprolol) were extracted by liquid/liquid extraction with ethyl acetate. The chromatographic separation was performed on reverse phase Phenomenax Luna column (C18, 5µm, 100 x 4.6 mm) with a mobile phase of 2 mM ammonium formate (pH 5.0) / methanol (20:80 v/v), which was pumped at a flow rate of 0.5 mL / min with split ratio of 20:80. The protonated analyte was quantitated in positive ionization by multiple reactions monitoring with a mass spectrometer. The mass transitions m/z 329.01→161.95 and 267.99→115.86 were used to measure Labetalol and Metoprolol, respectively. The lower limit of quantitation was 3.1800 ng/mL with a relative standard deviation of less than 15%. Acceptable precision and accuracy were obtained for concentrations over the calibration curve ranges (3.1800 to 700.8760 ng/ml). Sample analysis...
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Posted by admin on Dec 1, 2010 in |
Aceclofenac is an analgesic and anti-inflammatory agent used in the management of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. The objective of the present work was to investigate the effect of different types of carriers such as polyvinyl pyrrolidone (PVP), polyethylene glycol (PEG) 6000 and sodium lauryl sulphate (SLS) as solubilizer on in vitro dissolution of aceclofenac. Aceclofenac solid dispersions were prepared using 3² factorial design by fusion and solvent evaporation method with PEG 6000, PVP & SLS. Prepared aceclofenac solid dispersions were evaluated for physical appearance, drug content uniformity, and in vitro dissolution studies. The dissolution was determined by USP XXIII apparatus using phosphate buffer pH 7.4. The highest aceclofenac dissolution rate, 99.87% in 60 minutes, was obtained from solid dispersion containing SLS (ASS7) prepared by solvent evaporation method. The general trend indicated that there was an increase in dissolution rate for solid dispersions prepared in following order SLS>PVP>PEG 6000. IR and DSC studies showed no chemical change between drug and polymer and aceclofenac is homogeneously distributed in an...
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Posted by admin on Dec 1, 2010 in |
Ailanthus altissima Swingle (Simaroubaceae) is commonly known as “Tree of heaven”. The methanolic extract of root bark of A. altissima (MEA) was taken for anti-diarrhoeal activity. Investigations were carried out on castor oil induced diarrhoea and small intestine transit method on mice. In former method, MEA 200 (mg/Kg) were reducing the total weight of the faeces of group (0.163±0.028) in comparison to control group faeces (0.652±0.041), were statistically significant (P<0.001). In latter method, the MEA 200 (mg/Kg) inhibited 72.414% of the distance travelled by the charcoal and were significant statistically...
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