Posted by admin on Aug 15, 2010 in |
Felodipine, a calcium channel blocker, is used for hypertension and angina pectoris. Felodipine fast- disintegrating tablets (FDT) have been prepared by direct compression method. Effect of superdisintegrants (like crosspovidone, croscarmellose sodium and sodium starch glycolate) on wetting time, disintegrating time, drug content, in vitro release and stability parameter has been studied. Disintegrating time and dissolution parameter (t50% and t90%) decreased with increases in the level of croscarmellose sodium and crosspovidone whereas disintegration time and dissolution parameter increased with increase in the level of more than 5% sodium starch glycolate. The formulation did not show any change in disintegration time, wetting time and drug content after stability period. It was concluded that fast disintegrating Felodipine tablets can be prepared by direct compression using...
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Posted by admin on Aug 15, 2010 in |
The objective of the study was to develop HPMC matrix tablets for oral controlled/ sustained release of water soluble Diclofenac Potassium. Sustained release matrix tablets containing 100 mg of Diclofenac Potassium were developed using different drug polymer ratio of HPMC. Tablets were prepared by direct compression. Compressed tablets were evaluated for uniformity of weight, content of active ingredient, friability, hardness, thickness and in–vitro dissolution study. All tablets but one exhibited gradual and near completion sustained release for Diclofenac Potassium and 98.72 % released at the of 12 hours. The results of dissolution studies indicating that formulation D5 (drug to polymer 1:1.40) the most successful of the study, exhibited drug release pattern very close to theoretical release profile. A decrease in release kinetic of the drug was observed on increasing polymer ratio. Applying the exponential equation, all the tablets (except D5) showed diffusion dominated drug release. The mechanism of drug release from D5 was diffusion coupled with...
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Posted by admin on Aug 15, 2010 in |
Chlorthalidone is a phthalamide derivative of benzene sulphonamide and is designated as 2- chloro- 5- (1- hydroxy- 3- oxo- 1- isoindolinyl) benzene sulphanilamide. It is white to yellowish crystalline powder. It is practically insoluble in water, slightly soluble in alcohol. In the present study fast disintegrating tablets of chlorthalidone were prepared by adopting vacuum drying technique to study the effect of different subliming agents with various concentrations on disintegrating time. The powder blend was examined for the pre-compressional parameters. Formulations were evaluated for pre-compressional parameters such as angle of repose, % compressibility and Hausner’s ratio. Tablets were subjected to post-compressional analysis for the parameters such as hardness, friability, in-vitro disintegration time, wetting time and dissolution test. Drug compatibility with excipients was checked by FTIR and DSC studies. Stability studies were carried out as per ICH guidelines for three months. The results obtained showed that quantity of camphor, ammonium bicarbonate, menthol, and urea significantly affect the response variables (P> 0.05). The results revealed that tablets prepared by the vacuum drying...
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Posted by admin on Aug 15, 2010 in |
Diabetes, a global burden, is characterized by fast elevation of blood sugar level. The incidence of diabetes mellitus is rising all over the world, especially in Asia. Many oral hypoglycemic agents, such as biguanides and sulphonylurea are available along with insulin for the treatment of diabetes mellitus but they have significant side effects and sometimes they are found to be ineffective in chronic diabetic patients. Thus, there is an increasing demand of natural and synthetic products with high antidiabetic potential and lesser side effects. Lawsonia inermis(Henna) is a flowering plant of family Lythracea. Ethanolic extract was investigated for hypoglycemic and antihyperglycemic effect in normal and diabetic rats. Diabetes was induced in albino rats by a single intra-peritoneal ingestion of streptozotocin (45 mg/kg of body weight). Ethanolic extract of Lawsonia inermis was administered orally (150, 300 and 500 mg/kg of body weight) for 28 days and changes in body glucose were examined. The level of blood glucose was significantly increased in diabetic rats. Oral administration of ethanolic extract of Lawsonia...
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Posted by admin on Aug 15, 2010 in |
Natural products are an important source of new structures leading to drugs in all major disease areas. They represent a pool of privileged structures that are optimized by evolution to interact with proteins and other molecules. Bombax ceiba is an important medicinal plant of tropical and subtropical India. Its medicinal usage has been reported in the traditional systems of medicine such as Ayurveda, Siddha and Unani. The present commentary includes the detailed exploration of phytochemical properties along with the TLC ratios of various extracts of Bombax ceiba in an attempt to provide a direction for further...
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