Posted by admin on Jun 1, 2010 in |
Cordyceps militaris is an important medicinal mushroom useful for the extraction of several bio-metabolites for natural drugs to revitalize the various physiological systems of the body from the ancient era. The constituents of C. militaris are now using widely in the modern pharmaceutical industries. The active principles of C. militaris are beneficial to act principally as pro-sexual, anti-cancer, immunomodulatory, and anti-oxidant agent, let alone its others beneficial activities for most of the systems of the body. In addition, it has lots of clinical applications. The prospects of this novel mushroom could be used not only for modern medicinal manufacturers, but also for the community people for the betterment of their health. The present review highlights the importance of this medicinal mushroom C. militaris, also aiming to draw necessary attention of the researchers as a frontier...
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Posted by admin on Jun 1, 2010 in |
Paracetamol is an important anti-inflammatory and analgesic drug widely used in biological disorders. One of major problems with this drugs is its low solubility thus dissolution rate in biological fluid, which results into poor bioavailability after oral administration. In this study polyvinyl pyrrolidone (PVP) is used to enhance bioavailability of paracetamol. Paracetamol and PVP are used in 1:1 and 1:2 ratios to study the effect of PVP in dissolution profile of drug. Dissolution study showed a linear increase in paracetamol release with increase in polymer concentration. Two different batches of granules are also evaluated for their micromeritics properties and flow behavior. The micromeritics properties and dissolution profile showed a evident that PVP can be used to improve dissolution behavior of...
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Posted by admin on Jun 1, 2010 in |
Barberries are a large group of evergreen shrubs, found in Lalitpur, Allahabad, Bhopal and Haldwani etc. It is an evergreen shrub. Commonly, its fruits are called as berries. This plant is generally use in case of diabetes and mouth ulcer, as a traditional use. Type 2 diabetes mellitus (formerly called NIDDM, type II or adult-onset) is characterized by insulin resistance in peripheral tissue and an insulin secretory defect of the β- cell. This is the most common form of diabetes mellitus and is highly associated with a family history of...
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Posted by admin on Jun 1, 2010 in |
Psoralia corylifolia commonly known as Babchi, Bavachi in Hindi, is a well known herb in Indian system of medicine to treat various disorders including diabetes mellitus without any scientific evidences. Therefore this study was designed to investigate in vivo hypoglycemic and antidiabetic potential of methanolic extract of seeds of Psoralia corylifolia in glucose loaded animals and alloxan induced diabetic animals. In both the models Psoralia corylifolia reduced the blood glucose level when compared to diabetic control group and exert a significant hypoglycemic and antidiabetic activity. However the potency of the herb was less than that of standard drug metformin. Psoralia corylifolia methanolic extract also reversed the body weight in normal and alloxan induced diabetic animals. The results of this study revealed the presence of a significant antidiabetic potential of methanolic extract of Psoralia corylifolia in alloxan induced diabetic rats. On the basis of this further research work is needed to investigate exact mechanism of action and also to isolate the active constituent/s responsible for the...
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Posted by admin on Jun 1, 2010 in |
A simple, accurate, sensitive, reproducible and cost – effective spectrofluorimetric method was developed for the estimation of voglibose in bulk and pharmaceutical formulations. The solvent systems, wavelengths of detection (excitation and emission) were optimized in order to maximize the sensitivity and minimize the cost of analysis for voglibose. Derivatization procedure was employed for analysis. Voglibose showed strong native fluorescence in Methanol having excitation at 282 nm and emission at 345 nm. Effect of different solvents was thoroughly investigated. All parameters like the effect of different solvents, pH, dilutions, reaction time, temperature and effect of excipients were thoroughly investigated. The linear regression equations obtained by least square regression method for Fluorescence Intensity (FI) and concentration in ng/ml. The calibration curve was linear in the range from 100 to 350 ng/ml .The developed method was successfully employed with high degree of precision and accuracy for the estimation of total drug content in commercial tablet formulation of Voglibose (volix).The results of analysis were treated statistically, as per International Conference On Harmonization (ICH)...
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