Posted by admin on Mar 31, 2020 in |
In present study, a successful attempt has been made to study the variation in electrochemical behavior of Furazolidone and Metronidazole simultaneously using Differential Pulse Voltammetry (DPV) technique. The effect of different pH (2-10) of Britton-Robinson Buffer on voltammogram using 1M KCl as a supporting electrolyte was studied. The optimum pH was found to be pH 4.25. Both Furazolidone and Metronidazole exhibited reduction cathodic peak at optimum pH with peak potential at -0.06 V for Furazolidone, and -0.22 V for Metronidazole vs. S.C.E. 0.1N CH3COOH was used as Solvent for the analysis. The variation in electrochemical behavior of Furazolidone and Metronidazole simultaneously at the optimized pH was studied by varying pulse amplitude and scan rate. The optimized pulse amplitude was found to be 50 mV, and the optimized scan rate was found to be 15 mV/s. This study can be used developing methods for simultaneous detection and quantification of Furazolidone and...
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Posted by admin on Mar 31, 2020 in |
This study evaluates the effectiveness of corticosteroid fluticasone propionate, antihistaminic azelastine, and a combination of both as well as to find out the prognostic significance of absolute eosinophil count (AEC) in the topical treatment of allergic rhinitis. All cases presenting with symptoms of nasal allergy were included maintaining double-blind status. A total of 225 participants of groups I, II and III were treated with topical azelastine, fluticasone propionate and combination of both. The individual symptom score was recorded before and after treatment at the end of four weeks with the help of symptom evaluation scale. The effectiveness of group-specific drugs was evaluated by comparing individual and total symptom scores. AEC was repeated at the end of four weeks in all cases. After intervention the reduction of total symptom score (TSS) and AEC was 9.26 ± 0.01, 11.73 ± 0.54, 11.08 ± 1.61 and 205.59 ± 81.18, 176.05 ± 38.23, 195.75 ± 29.22 in group I, II and III respectively. Similarly for sneezing it was 0.21±0.41, 0.24 ± 0.43 and...
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Posted by admin on Mar 31, 2020 in |
In this study, attempts were made to evaluate the anti-microbial activity of the galls of Quercus infectoria Olivier against oral bacteria causing dental caries. Various solvents systems were used to screen the potential of the extract on the clinically isolated organism and reference strains; Candida albicans MTCC 183, Streptococcus mutans MTCC 497, Lactobacillus acidophilus MTCC 10307 and Staphylococcus aureus MTCC 1144 using agar-well diffusion method. This was followed by determination of minimum inhibitory concentration (MIC) by using two-fold serial microdilution methods at a concentration ranging between 0.02 mg/ml to 10 mg/ml. The MIC values against each bacterial species was found in the range of 0.16 to 0.31 mg/ml. Minimum bactericidal concentration (MBC) was obtained by subculturing microtiter wells which showed no changes in color of the indicator after incubation. Among all tested bacteria, S. aureus was the most susceptible. The clinically isolated S. mutans was further analyzed for its ability to form biofilm on the surface of seashells. The biofilm reduction percent assay in microtitre wells was used to...
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Posted by admin on Mar 31, 2020 in |
A series of novel 2-{[6-(2-substituted Phenyl)-2-oxo-1, 2-dihydropyrimidin -4-yl]oxy} benzoic acid (2a-b)/ 2-{[6-(2-substituted Phenyl)-2 thioxo-1, 2-dihydropyrimidin-4-yl]oxy} benzoic acid (2c-d) were synthesized and tested for their in-vitro protein denaturation activity. Compound 2d was found to be promising and was more potent than the Acetylsalicylic acid (NSAID) in the inhibition of Bovine serum albumin denaturation. The purity of the compounds was checked by TLC and elemental analyses. Both analytical and spectral data (1H NMR, IR, and MS) of all the synthesized compounds were in full agreement with the proposed...
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Posted by admin on Mar 31, 2020 in |
The purpose of current research work is to evaluate the in-vitro antioxidant and in-vivo hepatoprotective activity of Ganoderma lucidum strains DARL-4 and MS-1. Antioxidant activity of different extracts was evaluated by using DPPH and ABTS method. Hepatoprotective activity of hydroalcoholic extract of G. lucidum strain DARL-4 and MS-1 were evaluated by paracetamol-induced liver damage in rats. The hydroalcoholic extract of DARL-4 and MS-1 were orally administered to the animals at a dose of 300 mg/kg once daily for 14 days. On the 14th day the paracetamol (2 g/kg) was also orally administered. The degree of protection was measured by estimating the serum biochemical parameters. The result showed that the hydroalcoholic extract of DARL-4 and MS-1 showed potent antioxidant activity than the ethanolic, methanolic and aqueous extract. The serum biochemical parameters which were elevated due to paracetamol toxicity were significantly reduced. The histopathological studies also supported that extracts markedly reduced toxicity of paracetamol. The hydroalcoholic extract of MS-1 showed a more potent hepatoprotective effect than that of DARL-4. The present...
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