Posted by admin on Mar 31, 2020 in |
Free radicals are responsible for the development of many diseases. Anti-oxidants play an important role in scavenging free radicals. Anti-oxidant activity of herbal extracts and isolated compounds are reported earlier. Pharmaceutical industries are carrying out research in the development of new potent antioxidants. Novel drug development from economically cheapest plant waste might be useful for many pharmaceutical industries. Tender coconut mesocarp (TCM) is one of the cheapest plant materials used by coir industry etc. Aim of the present study is to analyses various phytochemicals present in the hydroalcoholic extract of TCM and evaluate its antioxidant activity in the in-vitro condition. Qualitative analysis of phytoconstituents present in hydroalcoholic extract (HAE) of TCM shows the presence of carbohydrate, phenolic compounds, flavonoids and tannin. Quantitative analysis of phytoconstituents in HAE shows the remarkable amount of phenols, flavonoids, tannin and vitamin C. LCMS analysis of HAE shows the presence of (±) 13-Azaprostanoic acid with maximum ppm (13.58) and 14 other compounds with ppm > 3n were identified. The IC50 value of HAE to...
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Posted by admin on Mar 31, 2020 in |
Increasing demand of herbal medicines in the treatment of diseases has once again gained the immense importance due to its viable efficacy and compliance to the patients. Cucumis sativus L. is commonly known as cucumber and Khayarain in Unani medicine. It is found wildly in the Himalayan regions and also cultivated throughout India. Maghze tukhme khayarain (seeds of Cucumis) is in use in traditional Unani medicine for various ailments such as Waram al-mathana (Cystitis), ziabetes (Diabetes), waram al-shoab (bronchitis), zaheer (diarrhoea), and renal diseases as it possesses musakkin-i-safra (yellow bile), muskkain-i-hiddat–i-dam(blood), Muhallil (anti-inflammatory) and Mudi-i-bawl (diuretic) properties. Not only seeds but other parts of the Cucumis such as root, leaves, flower, and fruits are also useful in various diseases. Further, the various part of the plant contains phytochemical constituents such as potassium, cucurbitacin A, B, C and D, flavanoid-fisetin, ascorbic acid, lactic acid, lariciresinol, pinoresinol and secoisolariciresinol, saponin and hypo-xanthine. Furthermore, it is pharmacologically proven for analgesic, anti-carcinogenic, anti-inflammatory, anti-microbial, anti-oxidant, diuretic, hypoglycemic, hepatoprotective and wound healing activities. As...
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Posted by admin on Mar 31, 2020 in |
Introduction: The aim of the present study is to formulate and evaluate the simvastatin chronopharmaceutical delivery system using a novel coating method to mimic the circadian rhythm of the disease by releasing the drug with a distinct predetermined lag time of 6 h. Observation: Simvastatin is a hyperlipidemia drug that inhibit the synthesis of cholesterol by inhibiting the HMG-COA reductase enzyme. Experiment: The basic design of the system consists of a rapid release core and a controlled release coat. The powder blend was evaluated for the angle of repose, Carr’s index, Hausner ratio, and compressibility index. The core tablet was evaluated for in-vitro release. The coated tablet was evaluated for weight variation, hardness, thickness, friability, disintegration, in-vitro dissolution, in-vitro comparative study, acid uptake test, rupture test, swelling studies, SEM, stability studies and FTIR, etc. Results and Discussion: The preformulation studies were revealed compatible results, and the rupture time, swelling time, acid uptake study showed satisfactory results by which it indicates the core molecule will be released at a prominent...
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Posted by admin on Mar 31, 2020 in |
Carissa spinarum is an evergreen, thorny shrub found in the Himalayan areas of the Indo-Pakistan subcontinent. The plant has a number of ethnomedicinal applications. Pharmacologically this plant is used for the treatment of asthma and pulmonary diseases, anticancer, diarrhea, hepatoprotective, cardioprotective and reproductive dysfunction. The present study is aimed to study effects of Carissa spinarum methanolic leaf extract in alloxan treated mice liver and kidney tissues. First group mice served as control and were given distilled water only. Second group mice were given Carissa leaf extract orally to a dose of 800 mg/kg body weight. Mice were injected with intraperitoneal injection of alloxan monohydrate at a dose of 120 mg/kg body weight and were further divided into three groups. Third group mice served as diabetic control and were given distilled water. Fourth and fifth group diabetic control mice were given Carissa leaf extract orally to a dose of 600 and 800 mg/kg bodyweight for 28 days. Sixth group mice were given glimepiride at a dose of 2mg/kg body weight....
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Posted by admin on Mar 31, 2020 in |
Objective: The present study is considered to estimate preliminary phytochemical components, physicochemical parameters, HPTLC chromatographic studies and antidepressant activity of chlorogenic acid & gallic acid present in extracts of Morus alba leaves. Methods: Total phenol content, total flavonoid content, total tannin content, HPTLC fingerprinting analysis for compounds like chlorogenic acid & gallic acid responsible for antioxidant activity and antidepressant activity by TST & FST. Result: Preliminary phytochemical studies shows the presence of good phenol (21.75 ± 1.21) and flavonoid (14.83 ± 2.34) content. HPTLC fingerprinting by comparing extract values with standards available of chlorogenic acid and gallic acid also shows the presence of these components in the methanolic and ethanolic extracts of Morus alba leaves, which were further used to screen antidepressant activity and shows substantial antidepressant activity in the plant. Conclusion: Our results recommend that Morus alba leaves are may be demonstrated to be an acceptable natural antioxidant and antidepressant with various bioactive components used for the treatment of numerous other...
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