Posted by admin on Mar 31, 2020 in |
For treatment or management of diseases, oral delivery is giving much more attention from the ancient decade. A new concept in oral delivery is mouth dissolving tablets (MDTs) are widely accepted nowadays. Mouth dissolving tablets are solid dosage forms which, when placed in the mouth, disintegrate, dissolve and release active agent within a few minutes without the need for water. It has more significance to geriatric, Pediatric, bedridden patients because they have a problem in swallowing and the patient with dysphasia. It is more useful for the traveler and busy patients who don’t have easy access to water. Mouth dissolving tablets are prepared by various technologies with the aid of superdisintegrants. Mouth dissolving tablets are more reliable than conventional dosage forms like tablets, capsules because of better patient compliance. The advancement in this field allows the development of an economic and better way of disease management with avoidance of several problems related to the other delivery...
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Posted by admin on Mar 31, 2020 in |
Simple RS method is developed and validated as reversed-phase chromatographic method for the identification and quantification of the dipyridamole related substances-A, B, C, D, E and F. Chromatographic separation has been achieved by using Shodex C18, 150 mm, 4.6 mm diameter, 5 µ column, using mobile phase 0.1 % of formic acid and acetonitrile by eluting in gradient with 1.0 ml flow, detection was achieved at 254 nm by maintaining 25 °C temperature for column. The method is validated as per the ICH guidelines. Linearity was recorded at various concentrations ranges 0.0100 – 6.0051 ppm for related substances A, B, C & 0.0040 – 2.4024 ppm of related substances D, E, F. Recovery RSD value of each related substance was <5.0 % (n=9). RS method for related substances in dipyridamole is found specific, linear, accurate, precise, rugged and robust hence the validated method is suitable to identify the related substances in dipyridamole...
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Posted by admin on Mar 31, 2020 in |
The study aimed at checking the effects of aqueous extracts of Vernonia amygdalina and Ocimum gratissimum on the electrolyte level of salt-loaded rats. 25 male rats weighing 160-220g were shared into 5 groups of 5 rats. Group 1 animals that were fed standard feed and water served as the control. Animals in group 2-5 which were salt-loaded orally with 2 ml of 4% sodium chloride solution for 2 weeks, were left untreated, treated with 1 ml of 300 mg/kg body weight of aqueous bitter leaf extract, 300 mg/kg body weight of aqueous extract of scent leaf and 300 mg/kg body weight of both extracts in ratio 1:1 respectively. Treatment of salt-loaded animals with the extract was done orally once daily for two weeks after which plasma electrolyte levels were determined. There was significant (P<0.05) increase in Na+ and Cl− levels in all the salt-loaded groups when compared with the control group. Bitter leaf extracts significantly (P<0.05) decreased the sodium level only when compared to the group with no treatment...
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Posted by admin on Feb 29, 2020 in |
Biosynthesis of nanoparticles by biological means especially plant extract plays a major role in the field of nanotechnology. In the present study, the aqueous extract of lemon peel (Citrus limon) was used for the green synthesis of ZnO nanoparticles using 0.1 M Zn(NO3)2 as a precursor in alkaline condition using NaOH with vigorous stirring for 3 h. ZnO NPs obtained were characterized by UV-vis spectroscopy in which the surface Plasmon resonance was 310 nm, followed by XRD, FTIR that showed appropriate speaks for various chemical groups present including ZnO NPs and AFM results shows monodispersed in nature. Further, the antibacterial property of ZnO NPs synthesized by the green method was revalued by the well diffusion method. The zone of inhibition was found to be 9 mm for 100 µL and 7 mm for 100 µL for respective strains Klebsiella aerogene and Serratia marcescen. Significant antioxidant activity was exhibited by NPs through scavenging of 1, 1-Diphenyl-2-picrylhydrazyl (DPPH) free radicals. Thus, the use of aqueous peel extract as a capping agent...
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Posted by admin on Feb 29, 2020 in |
Background: Subnormal level of vitamin D are associated with the higher frequency of cancer and correlated with inferior prognosis in some cancers; no data exist for acute leukemia. Aim of the work: To clarify the relationship between serum vitamin D levels and acute leukemia in children. Materials and Methods: Vitamin D level was measured in sixty-six pediatric patients who are newly diagnosed with acute leukemia in Central Child Teaching Hospital during a period between March 5th to August 30th, 2017 and normal 50 children were considered as the control group. Information on the patients were obtained from the medical files of the patients. Patients were classified on a random base as active patients group how the received daily requirement of vitamin D during induction chemotherapy period and passive patients’ group who were treated with chemotherapy only. Vitamin D level was reassessed at the time of remission. Results: The serum vitamin D level in children with acute leukemia was below normal ranges; at the time of diagnosis, the mean of...
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