Posted by admin on Feb 29, 2020 in |
Development of a sustained release liquid oral in-situ gel of Voriconazole with improved bioavailability has been the main aim of this project. Complexation of the drug with hydroxypropyl beta-cyclodextrin was done to improve the solubility and stability of the drug. The mucoadhesive polymer carbopol 934P and release retardant HPMC E50 were used as factors and a two-square factorial design was employed. A simple mixing method was used for the formulation, and evaluation was done. The polymers had a significant effect on gelation time, mucoadhesive strength, and 8 h drug release. Carbopol showed a better- controlled release and mucoadhesive strength than HPMC E50. The experimental values for gelation time, mucoadhesive strength, drug release at 1 h, 8 h, 12 h, and gel strength were found to be 80 sec, 17453 dynes/cm, 21.10%, 62.98%, 90.54%, 55 sec respectively, which were close to the predicted values. Pharmacokinetic studies revealed a 12 h sustained drug release, plasma drug concentrations above 0.5µg/ml (MIC) and 6.76-fold increase in bioavailability. Thermal and photostability studies revealed a...
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Posted by admin on Feb 29, 2020 in |
Lung cancer is a malevolent lung growth characterized by unrestrained cell expansion in tissues of the lung. EGFR is occupied dissimilar fundamental presentation of cancer cells that includes expansion of cells, enlargement, propagation, apoptosis regulation etc. make it a prime objective for lung cancer. EGFR is a tyrosine kinase inhibitor that is proposed in epithelial cells. EGFR inhibitors are drugs that connect to firm parts of EGFR and stop the expansion of cells. Till date, EGFR inhibitors are classified into two categories first one is tyrosine kinase inhibitor and the second one is monoclonal antibodies. Tyrosine kinase inhibitor binds to the area of tyrosine kinase in the epidermal growth factor receptor and hinders the activity of EGFR. Monoclonal antibodies bind to the extracellular components of EGFR prevent it to bind with its own receptor so that stop cell division. This review encompasses complete updates on a generation of epidermal growth factor receptor tyrosine kinase inhibitor used in the treatment of non-small cell lung...
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Posted by admin on Feb 29, 2020 in |
The present study aimed to understand, phytochemistry and antioxidant property of five members belonging to Apocynaceae, Catharanthus roseus (L) G. Don; Plumeria alba L.; Pentalinon luteum (L) B. F. Hanson & Wunderlin; Rauvolfia tetraphylla L and Nerium oleander L. The preliminary phytochemical analysis was carried out using the methanolic extract for protein, carbohydrate, alkaloids, phenol, tannin flavonoids, and saponin. They were quantified using spectrophotometer using different standards and methods like the Bradford method using BSA as standard for protein, phenol-sulphuric acid method using glucose as standard for carbohydrates, Folin-Ciocalteau method by Sidduraju and Becker for phenol using catechol as standard, tannins using Folin-Ciocalteu method using tannic acid as standard, Zhishen et al., modified method for flavonoids using quercetin as standard. Total alkaloids were estimated using the dry weight method. Antioxidant properties were studied using the ability of the Soxhlet extracts of the plant samples to scavenge the DPPH radicals using Blois method with modifications. The highest concentration for protein was found in Rauvolfia tetraphylla, and the lowest concentration was found...
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Posted by admin on Feb 29, 2020 in |
Rheumatoid arthritis is an autoimmune disease that involves inflammation of joints. Diclofenac diethylamine, as well as Curcumin, are widely used for symptomatic relief of pain and inflammation. The present study was aimed at providing a simple, accurate and economical spectrophotometric method for simultaneous determination of curcumin and diclofenac diethylamine from topical gel formulation. Simultaneous determination of both drugs namely, curcumin and diclofenac diethylamine was done by Absorbance correction method using phosphate buffer 5.5: ethanol (1:1) as the solvent. A topical gel containing curcumin microspheres and diethylamine were prepared using carbopo l971 as a gelling agent along with propylene glycol, preservatives, and triethanolamine. Diclofenac diethylamine showed an absorbance maximum at 278 nm whereas curcumin showed at 428.4 nm in phosphate buffer 5. 5: ethanol (1:1). The linearity of both drugs was found in the concentration range 2-26 μg/ml for Diclofenac diethylamine and 1-7 μg/ml for Curcumin respectively. This method was then applied successfully to pharmaceutical dosage form gel and no interference of excipients was found. Recovery for curcumin and diclofenac...
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Posted by admin on Feb 29, 2020 in |
Chemically, rhein is 9, 10-Dihydro-4, 5-dihydroxy-9, 10-dioxo-2-anthracenecarboxylic acid, and use as an intermediate to synthesize diacerein which widely used in the treatment of degenerative diseases like, osteoarthritis, osteoporosis, and rheumatoid arthritis and hence has commercial importance. Rhein occurs in free state in nature in different plant families like Cassia, Rhamnus, and Rheum but in very less concentration and as it is currently subject of interest because of its anti-tumor, anti-viral and anti-oxidant properties, therefore, there is need for simple and efficient isolation and extraction method to obtain rhein from available indigenous plant sources. A modified method developed for the isolation of rhein from Cassia angustifolia leaves is described, the method involves oxidative hydrolysis of sennoside with help of an oxidizing agent followed by the isolation of the rhein from reaction mixture, and with substantial yield improvement is achieved. The objective of this study to optimize yield of the rhein from senna semisynthetically. The isolated rhein was analyzed by spectral analysis for its...
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