Posted by admin on Feb 29, 2020 in |
Rheological properties of carboxymethyl locust bean gum (CMLBG) solutions having different concentrations and solution pH were evaluated through steady shear and oscillatory measurements and were used to describe the erosion propensity of CMLBG coat of compression coated placebo tablets. CMLBG solutions, irrespective of concentration and solution pH, exhibited predominant viscous character as the viscous modulus (G”)> elastic modulus (G’) and phase angle (Tan δ) > 1. The viscous contribution was found to be influenced by both the CMLBG concentration and solution pH. An increase in CMLBG concentration increased the pseudo-plasticity and consistency coefficient and decreased the viscous contribution in all solution pH resulting in a decrease in erosion of CMLBG coat. The higher viscous character of CMLBG in buffer solution of pH 7.4 (Solution B) was responsible for higher erosion of the coat than in acid solution of pH 1.2 (Solution A). When the pH of acid solution of CMLBG was increased dynamically from 1.2 to 7.4, the viscous contribution decreased to some extent than that observed in Solution...
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Posted by admin on Feb 29, 2020 in |
Cold and hot methanolic extract of leaves and whole plant parts of Andrographis paniculata were tested against gram-negative Escherichia coli (MTCC 1679) Klebsiella pneumonia (MTCC 4032) Streptococcus pyogenes, Solmonella typhimurium (MTCC733) and gram-positive Staphylococcus aureus (MTCC737). Maximum activity among all the bacterial cultures tested was showed against E. coli MTCC1679 when compared with their standards. Next to E. coli, MTCC1679 best inhibition was seen against S. aureus (MTCC737). There was no inhibition reported against, K. pneumonia, S. pyogenes, Salmonella typhi. The studied result revealed the highest activity in 75% methanolic extract. The highest zone of inhibition (22 mm) was observed against E. coli at a dose of 3.0 mg. The antibacterial activities of 75% methanol extract from A. paniculata leaves were observed only against the E. coli. The extract was not found active against other tested bacterial pathogens. The Andrographolide compound was analyzed by HPLC chromatogram and the standard of the given andrographolide compound was also prepared by the...
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Posted by admin on Feb 29, 2020 in |
Hollow microballoons (microspheres) are spherical empty particles without core. Microballoons (Hollow microsphere) are a drug delivery system that promises to be a potential approach for gastric retention. Microballoons drug-delivery systems are based on a non-effervescent system containing empty particles of spherical shape without core ideally having a size less than 200 micrometers. Microballoons drug delivery systems have shown to be of better significance in controlling the release rate for drugs having site-specific absorption. The floating microballoons showed gastro retentive controlled release delivery with efficient means of enhancing the bioavailability and promises to be a potential approach for gastric retention. Optimized hollow microspheres will find the central place in novel drug delivery, particularly in safe, targeted and effective in-vivo delivery promises to be a potential approach for gastric retention. They are gastro retentive drug-delivery systems, which provide controlled release properties. The advantages, limitations, methods of preparation of hollow microsphere, applications, polymers used in hollow microspheres, characterizations of microballoons and formulation aspects with various evaluation techniques and marketed products are covered in...
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Posted by admin on Feb 29, 2020 in |
A major challenge in treating bacterial infections is the increasing incidence of microbial resistance to antibiotics. This poses a serious threat prompting the search for alternative strategies to treat bacterial infections. Metal nanoparticles as novel antibiotic agents hold promise because they show strong antibacterial activity against various bacterial species, including Gram-positive and Gram-negative bacteria. Green synthesis of nanoparticles offers minimization of wastage, reduction of derivatives, use of non-toxic solvent, auxiliaries and renewable feedstock. A single step, an eco- friendly, cost-effective method is used for the synthesis of copper nanoparticles (CuNPs) from 1.0 mM copper sulphate solution using extract of Ocimum sanctum (Tulsi) leaves as reducing and capping agent. UV-VIS, FESEM, FTIR and XRD were used to confirm and characterize the NPs. The biosynthesized copper NPs were phased pure and well crystalline with a simple cubic structure. Antibacterial study of the biogenic CuNPs suggests their efficacy against common human bacterial pathogen species. Gram-negative test organisms were found to be more susceptible to toxicity of biosynthesized CuNPs. Metal nanoparticles hold the...
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Posted by admin on Feb 29, 2020 in |
Green analytical chemistry is an attempt to reduce the environmental hazards caused by chemicals and chemical processes. To avoid the use or formation of dangerous materials, the best way is to prevent pollution rather than cleaning up the process. Therefore, it is important to choose a method with the least harmful effects on the environment. The main focus or aim of green chromatography is to make a method greener at each and every step of analysis from sample collection to its determination. The present review includes the goals to achieve green chromatography using environmentally benign solvents and reagents, most recent contribution in the development of greener sample preparation since it has effect on whole analytical methodology, chromatographic separation techniques, advantages of green chromatography, green microextraction techniques (solid-phase microextraction, still bar sorptive, liquid-phase microextraction) are included. The aim is to make chromatographic separations greener, depending on the type of chromatography which includes the solventless extraction...
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