Posted by admin on Jan 31, 2020 in |
Introduction: Benign prostatic hyperplasia (BPH) is a common age-related burden of males and found in more than 40% of men in their fifties. In Ayurveda, Vatasthila and Mutragranthi are condition mentioned under Mutraghata much resembles obstructive uropathy due to BPH. In modern medicine, management of benign prostatic hyperplasia (BPH) is either by surgical approach or by hormonal therapy and alpha-blocker etc. which has many complications. Thus, there is a need to update of herbal medications for treatment of BPH. The presented review article provides information on BPH and its treatment by herbal drugs. Materials and Methods: This review work was carried out by using a widespread and planned data mining approach through a search of the english-language literature indexed on Medline, Pubmed Central Journal Literature, scopus, web of science google scholar, science direct and the proceedings of scientific meetings. To achieve significant literature author uses the key words “herbal drugs in BPH”, “benign prostatic hyperplasia” “role of Ayurveda in BPH” and “current update for BPH Treatment. Results: nine publications...
Read More
Posted by admin on Jan 31, 2020 in |
Bacteria have proved remarkably developing resistant to a known antibiotic; however, Medicinal plants have manifested notably useful for the control of bacterial infections. This study aimed to isolate and identify the multidrug-resistant bacteria from wound infection, then examine the antibacterial activity of different concentration of the ethanolic extracts of Cymbopogon proximus, Azadirachta indica, and Grewia senegalensis plants against it. One hundred specimens collected from wound infection, isolation and identification done according to standard methods. Antibiotics susceptibility test performed using the Kirby-Bauer disc diffusion method for: Cotrimoxazole (25 μg) Ciprofloxacin (5 μg), Gentamicin (10 μg), Imipenem (10 μg), Erythromycin (15 μg), Tetracycline (30 μg) Methacillin (5 μg), Ceftazidime (30 μg). 94 isolates showed bacterial growth, 40 (42.6%) isolates were Gram-positive bacteria (Staphylococcus aureus) and 54 sample Gram-negative bacteria; 15 (27.8%) Pseudomonas aeruginosa, 13 (24.1%) Proteus spp, 12 (22.2%) Escherichia coli, 10 (18.5%) Klebsiella pneumonia, 4 (7.4%) Citrobacter freundii. Ethanolic extracts from Sudanese medicinal plants namely Cymbopogon proximus, Azadirachta indica, and Grewia senegalensis, screened for their antimicrobial properties against isolated multidrug-resistant...
Read More
Posted by admin on Jan 31, 2020 in |
Blood transfusion is an important part of various treatment protocols. Blood should be transfused with certain precautions like drug because blood and its constituents have the propensity to cause effects like introduction of donor antigens within the recipient, transfusion reactions or exposure to numerous transfusion-transmitted diseases. Thereby, it is important for the clinicians to remember those potential risks to the recipient of blood and blood components as well as donors. Haemovigilance system includes monitoring, identification, reporting, investigation, and analysis of adverse reactions associated with transfusion. The data gained from the investigation and analysis facilitates corrective and preventive action to be taken to attenuate the potential risks related to safety and quality of blood donation and transfusion for donors and patients. Forever the developed countries have taken the lead within the haemovigilance. However, developing Asian countries like India lacks a well-established system for haemovigilance program. In this review we have compiled the various haemovigilance and blood safety studies conducted in India to know the current update of haemovigilance program in...
Read More
Posted by admin on Jan 31, 2020 in |
In aerobic organisms, oxygen is essential for sufficient energy production but self-contradictory, produces chronic toxic stress in cells. So, protective techniques must exist for removal of toxic free radicals which are byproducts of oxygen. Diverse protective systems have evolved to enable adaptation of antioxidant activity. Tissues and organs have different rates of metabolic activity and oxygen consumption. Their levels of antioxidants are also different. Such is the case with glutathione (GSH) and cysteine, which are lower in the brain than the liver, kidney, or muscle. Investigations of oxidative responses in different complex organisms such as mammals, organs, and tissues which contain distinct antioxidant systems and this may form the basis for differential susceptibility to toxic agents. Notable advances have been made in our understanding of these distinct systems, with several antioxidant systems and their regulatory pathways being described at the cellular level, thus understanding the pathways leading to the induction of antioxidant responses will enable development of strategies to protect against oxidative...
Read More
Posted by admin on Jan 31, 2020 in |
Quercetin is a plant flavonol that is available from both daily diet and nutraceuticals. Various studies report that Quercetin alters the pharmacokinetics of various drugs by mechanisms like p-glycoprotein (p-gp) inhibition or other unknown mechanisms. The study was undertaken to evaluate the effect of Quercetin on the pharmacokinetics of Eletriptan. A single dose in-vivo pharmacokinetic study was carried out in rat models. In this study, rats were treated with Quercetin (10 mg/kg) and Eletriptan (2 mg/kg) orally and blood samples were collected at various time points such as 0 (predose), 0.5, 1.0, 1.5, 2.0, 2.5, 3.0, 3.5, 4.0, 6.0, 8.0, 12, 24 h post-treatment. Plasma concentration of Eletriptan was estimated using the HPLC method. AUC (0-24) of Eletriptan has significantly (p<0.01) increased in the Eletriptan and Quercetin combination group 1451.98 ± 93.78*** (ng/ml/h) when compared to AUC (0-24) Eletriptan alone treated group 883.94 ± 77.25 (ng/ml/h). AUC0-∞ of Eletriptan has significantly (***p<0.001) increased in the combination group (1543.32 ± 182.39*** (ng/ml/h).) in comparison to AUC0-∞ of Eletriptan of Eletriptan...
Read More
