Posted by admin on Nov 30, 2020 in |
Moringa oleifera, a miracle plant, is praised for beneficial health nutrients and has potential cholesterol-lowering activity. Almost all the parts of the Moringa oleifera plant have potential bioactivity. The main active constituents of Moringa oleifera are flavonoids, alkaloids, phenols, vitamins, minerals, proteins, glycosides, Glucosinolates and Isothiocyanates, terpenes, saponins, tannins, and many more. The Moringa oleifera has potent activity towards various ailments such ascancer, diabetes, inflammatory, antibacterial properties, cardiovascular diseases, and many more. Hyperlipidemia is referring to the increase in the level of lipid in plasma, and that leads to cardiovascular diseases. Antihyperlipidemic activity of Moringa oleifera is reported to be due to phytochemicals such as flavonoids, phytosterols, and phenols. This review mainly focuses on the pharmacological role of Moringa oleifera in the treatment of hyperlipidemia. The present article also describes the bioactive constituents of Moringa oleifera and its therapeutic...
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Posted by admin on Nov 30, 2020 in |
Urinary tract infection (UTI) is one of the common clinical conditions in patients presenting to the tertiary care hospital. In general, most of the case of UTI was being treated by empirical antimicrobial therapy before the laboratory results of urine culture; since the antimicrobial susceptibility test of uropathogenic bacteria and antibiotic resistance for enhanced management of UTI with a commonly used antibiotic. A prospective observational study was conducted on significant bacteria isolated from the urine samples submitted in microbiology unit from April 2017 to September 2017 at tertiary care hospital in Kathmandu, Nepal. E. coli (52.5%); the predominant etiological organism of UTI in our study showed high sensitivity to nitrofurantoin (93.3%), meropenem (92.9%), and colistin (82.3%). The most effective antimicrobial agent against Gram-positive Enterococcus species were linezolid (100%), vancomycin (100%) and nitrofurantoin (100%). A very high rate of resistance was seen against amikacin (75%), nalidixic acid (68.7%), and cotrimoxazole (63.9%) in Gram-negative bacilli isolates of E. coli. Escherichia coli, the most common uropathogens isolated more commonly from the female...
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Posted by admin on Nov 30, 2020 in |
A simple, accurate, and precise stability-indicating reverse phase high pressure liquid chromatographic method was developed and validated for the estimation of Perindopril arginine, Indapamide, and Amlodipine in the bulk and pharmaceutical dosage form. Chromatographic separation was carried out on ZORBAX RX C8 (250 mm × 4.6 mm, 5 µm) as a stationary phase with a mobile phase of gradient system of Phosphate Buffer with pH 2 containing Decane Sulphonate as ion-pairing agent (A) and Acetonitrile (B) at detection wavelength 215 nm with flow rate 1.0 mL/min at column temperature 40 ºC. The tR of Perindopril, Indapamide, and Amlodipine was 31.39 ± 0.21 min, 25.73 ± 0.41 min, and 36.95 ± 0.47 min, respectively. The method was linear over the concen-tration ranges 50-150 µg/ mL for Perindopril, 12.5-37.5 µg/ mL for Indapamide and 50-150 µg/ mL for Amlodipine. The LOD was 0.99 µg/ mL for Perindopril, 0.87 µg/ mL for Indapamide and 3.99 µg/ mL for Amlodipine. The LOQ was 3.02 µg/ mL for Perindopril, 2.6 µg/ mL for Indapamide...
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Posted by admin on Nov 30, 2020 in |
Portulaca oleracea belonging to the family Portulacaceae has a wide occurrence throughout the World. It has numerous nutritional and medicinal benefits to humans because it is a good source of many minerals, vitamins, fatty acids, alkaloids, flavonoids, aspartic acid, coumarins, glutathione, etc. It is used in the traditional system of medicine in many countries like India, Nigeria, Palestine, China, Iran etc. for the treatment of various ailments like edema, ulcers, indigestion, repro-ductive system disorders, etc. The present review focuses on pharmacological activities of P. oleracea like anti-inflammatory, anti-diabetic, protective effect on the reproductive system, hepatoprotective, and antimicrobial effects. The analysis of recent researches on the above aspects will further, validate the use of P. oleracea as a medicinal...
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Posted by admin on Nov 30, 2020 in |
Permethrin, a member of one of the newest class of insecticides, the synthetic type-I pyrethroids, is very much in use nowadays. Due to its relatively low mammalian toxicity and high photostability, it has earned great popularity. Several reports suggest its endocrine disrupting activity, damaging effect on nervous system, its receptors, and other adverse effects. However, very limited information is available regarding its effect on reproductive organs. It is, therefore, imperative to bridge these lacunae. Hence, the present study was aimed to evaluate the effects of Permethrin on the reproductive tissues of male mice. Permethrin (130 mg/kg body weight) was administered orally for a period of 21 days. Biochemical parameters were assayed in testis, caput epididymis, cauda epididymis, seminal vesicle, and vas deferens of Swiss albino mice. The results showed that Permethrin administration lowered the gravimetric indices and decreased the levels of enzymes involved in the energy metabolism like ATPase, ALKPase, ACPase, and SDH, which may lead to oxidative stress and hamper the overall physiological...
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