Posted by admin on Jan 31, 2020 in |
Now a day’s control delivery of the drug is easily achieved by Microsponge delivery system. These microsponges are very similar to polymeric porous microspheres. In general microsponges are 5-300 micron in diameter, spherical in shape, large porous surface, tiny in structures. Microsponges generally used in the topical drug delivery system but recently they are used for oral administration of drugs. Microsponges deliver its drug on regular time intervals and also respond to the other stimulations. A microsponge has advantages that they modify the release of the drug enhances the stability and effectively reduces the side effects of the drugs. The main aim of formulation is to achieve desired concentration of the drug in the blood. When these microsponges used topically they prevent the accumulation of the drug in both dermis and epidermis. Microsponges can easily entrap and formulated into pharmaceutical product such as gels, creams, powders, liquids, and suspensions. One of the best features of microsponges is it has self-sterilization property; numerous study has confirmed that microsponges are non-...
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Posted by admin on Jan 31, 2020 in |
Large-leaf gentian herb is a promising source of biologically active substances, which is actively used in the traditional medicine of many countries. It contains flavonoids, iridoids, secoiridoids, polysaccharides, xanthones with a wide spectrum of pharmacological activity. The aim of the research was to establish a procedure for identification of large-leaved gentian (Gentiana macrophylla Pall.) using thin-layer chromatography (TLC). In order to identify both hydrophilic and hydrophobic compounds in extracts from the plant two mobile phases were proposed which allow distinguishing specific zones by their color and relative position. Validation of developed procedure was carried out in terms of specificity and chromatographic system suitability. The specificity of the procedure was assessed by matching of TLC profiles for all studied samples. It was found that the main zones on the chromatograms are matching. Thus, chromatographic characteristics of large leaf gentian aerial parts were established for the first time using validated TLC procedure. The results of the study can be used for standardization of large-leaved gentian...
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Posted by admin on Jan 31, 2020 in |
Introduction: Medicinal plants have always played a major role in primary health care system since time immemorial. Sacred natural sites is the prime place to encompass large medicinal plant with wide range of natural resources. It potentially conserves plant biodiversity with inclusion of sacred places and sacred water bodies. Apart from social and religious importance it, regulate air and water quality of environment. The purpose of this study was to document the floristic diversity and traditional approaches towards the ethnomedicinal plants of Sacred Natural Sites of Panchkoshi Pilgrimage of Varanasi district, Uttar Pradesh India. Methods: An ethnobotanical survey was conducted from May 2016 to April 2018. The information collected through open-ended and semi-structured questionnaire and data were analyzed through Informant consensus factor (ICF). Results: During the field study, 66 medicinal plant species belonging to 62 genera and 36 families used to heal different illnesses were recorded. Fabaceae has the dominant family with 8 plant species and Apocynaceae and Moraceae with 5 plant species followed by Malvaceae, Poaceae, Solanaceae, and...
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Posted by admin on Jan 31, 2020 in |
Quinolines bears a very good synthon so that a variety of novel heterocyclic with good pharmaceutical profile can be designed. There are various biological activities for quinolones such as antibacterial, antimalarial and various drugs possessing quinolone as nucleus are ciprofloxacin (Cipro), lomefloxacin (Maxaquin), norfloxacin (Noroxin), ofloxacin (Floxin), moxifloxacin (Avelox) and levofloxacin (Levaquin). So, in the present work 2-chloro quinoline 3-carbaldehyde containing quinolines were synthesized by using solvent conservation techniques like reflux technique. Various quinolines derivatives were synthesized by the condensation reaction between dimethylformamide, PoCl3, and different substituted aniline to give 2-chloro 3-carbaldehyde (1a). The reaction of 2-chloro 3- carbaldehyde with metformin gives quinolines Schiff bases as final compound (2a-2d). The obtained product was purified and structures were confirmed by TLC, MP & IR spectroscopy. All the compounds were screened for in-vitro anti-inflammatory activity using diclofenac sodium as standard by using protein denaturation method. Further, the selected compounds also studied for anti-inflammatory activity by in-vitro methods and anti-oxidant activity by hydrogen peroxide methods. Some of the compounds have shown significant...
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Posted by admin on Jan 31, 2020 in |
Capparis moonii wight is a large woody climber or shrub (locally known as Rudanti) having Rasayana (rejuvenating) actions and it is being used in respiratory diseases like cough, bronchial asthma and pulmonary tuberculosis by ayurvedic physicians. It is one of the drugs which have references for its use from centuries but still not much explored in this contemporary era. The review aims to provide a critical and comprehensive evaluation, from the ancient times to our days, of the ethnological, botanical, chemical and pharmacological aspects of Capparis moonii, with a vision for promoting further pharmaceutical research to explore its complete potential as a therapeutic agent. This study was performed by reviewing in extensive details the studies on historical significance and ethnopharmacological applications of Capparis moonii by using classical ayurvedic texts, international scientific databases, books, etc. In addition, the plant taxonomy was validated using certified databases such as Medicinal Plant Names Services (MPNS) and the plant list. A detailed comparative analysis of the available sources for Capparis moonii wight confirmed that...
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