Posted by admin on Dec 31, 2019 in |
The main objectives of the present study were to design, optimization and evaluation of buccal drug delivery system of propranolol for hypertension treatment. Propranolol is non-selective β-adrenergic blockers. It shows first-pass metabolism so its bioavailability is decreased and its absolute bioavailability is only about 26%. The buccal tablets of propranolol formulated, by using different mucoadhesive polymers such as sodium crosscarmilose sodium, PVP K30, and HPMC K15M. F8 was containing 18.18% PVPK30, 10.90% HPMC K15M showed desired drug release within 6 h to above batches. The dissolution profile of formulated batch F1 to F8 at the end of 6 h was found in the range of 83.03 to 94.69% in phosphate buffer pH 6.8. From the results, it was found that formulation F8 was shown most similar dissolution profile because the similarity value was found to be above 90%. The swelling index was found higher in formulation F9 80.15% swelling observed because of higher concentration of PVP K30 and HPMC K15M. The results indicate that out of two bioadhesive polymers...
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Posted by admin on Dec 31, 2019 in |
Cymbopogon olivieri (Poaceae) is a native plant to the south of Iran and is used for the treatment of some inflammative based disorders and as a pain killer. Regarding the presence of volatile terpenoids in the aerial parts, we were prompted to investigate the analgesic and anti-inflammatory activities of the essential oil from C. olivieri in animal models. The oil was also analyzed by GC and GC–MS to identify the potentially responsible compounds for observed properties. The analgesic activity of the oil was assessed by acetic acid-induced writhing test and hot plate method while the acute anti-inflammatory effect was investigated by induced-inflammatory paw edema in the rat. The studied oil could decrease the number of acetic acid-induced writhes in mice compared with animals that received vehicle only. In hot-plate tests, the studied doses of C. olivieri were not effective. The oil moderately reduced carrageenan-induced paw edema in rats. The major component of the oil was characterized as Piperitone (66.0%), which might be responsible for these observed activities. The results...
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Posted by admin on Dec 31, 2019 in |
Phytase catalyzes the formation and release of inorganic phosphate from phytic acid. A few monogastric animals that lack phytase is incapable of digesting phytate obtained from plants and gets excreted, which results in the accumulation of phosphorus in the form of phytate in the environment which has a detrimental effect. In order to combat this problem, researchers have focused on production and purification of phytase from different microbial sources, which converts phytate to useful form of phosphorous that facilitates plant growth. This review paper summaries the various methods adopted for isolation, production, and purification of phytases from various...
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Posted by admin on Dec 31, 2019 in |
The vast investigations on the derivatives of 1, 2, 3-benzotriazole explore wide applicability for tagging and delivering a number of other heterocyclic nuclei with benzotriazole. In the present work, several derivatives of 1-(substituted)-5- [(N-benzotriazolo-methyl)-1, 3, 4-thiadiazolyl]- imidazole-2-thione have been synthesized and are evaluated for their anticonvulsant activity. The anticonvulsant activities of the synthesized derivatives were assessed by the maximal electroshock (MES) method. Electric shock (50 mA for 0.2 sec) was delivered with the help of a corneal electrode to induce hind limb tonic extension. The synthesized derivatives X2, X3 and X6 exhibited significant anticonvulsant effect against MES-induced seizure model as an indication for compounds which are effective in grand mal...
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Posted by admin on Dec 31, 2019 in |
Bacteria predominantly remain in a self-produced polymeric matrix, adherent to an inert or living surface. This microenvironment community of bacteria is known as biofilm. Commonly visualized as a slimy layer, a number of unique features distinguish biofilms from their planktonic counterparts. Formation of biofilms depends on the extracellular signals, mechanical, biochemical, environmental conditions and genetic factors in bacteria. The attachment of biofilms is an intriguing process which is regulated by several characteristics such as substratum, cell surface, and growth medium. These biofilms cause various infections and are of at most importance when concerned about public health. One of the challenges faced during antibacterial drug development is to create compounds to counter-attack the biofilm infections. In this study, antibiofilm activities of five essential oils (EUGENOL; CINNAMALDEHYDE; PIPERIDINE; LIMONENE) were discussed. This review consisting of explicit evidence proved that plants are indeed a wonderful source to provide naturally occurring compounds for development of therapeutic and preventive agents against infections caused by...
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