Posted by admin on Dec 31, 2019 in |
Amphotericin B is among the gold standard antifungal agents used for the treatment of the wide range of fungal infections. Work aimed to formulate the amphotericin B (AmB) ethosomal gel (EF), evaluate its antifungal activity against fungal isolates of human origin and compare its antifungal activity with marketed liposomal gel (MLG). AmB ethosomal gel (EF) was formulated and characterized for their physical appearance, pH, spreadability, viscosity, drug content, zeta potential, in-vitro diffusion study and in-vitro and in-vivo antifungal study. The results showed that pH value was within acceptable limits (6.2 ± 0.021). EF showed better spreadability than MLG. EF showed highest drug content (97.3 ± 0.43 %) than that of MLG (76 ± 0.32%), better spreadability and more negative zeta potential to confirm the stability of the formulation. AmB EF showed the highest zone of inhibition (28 ± 0.20 mm), in contrast to MLG (24 ± 0.13 mm) against Candida species. The in-vitro and in-vivo studies revealed effective therapeutic potential against Candida albicans induced dermal mycosis. Result of this...
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Posted by admin on Dec 31, 2019 in |
Depression is a common heterogeneous, debilitating and life-threatening mood disorder affecting different segments of the community. Several chemical and synthetic medicines as standard are being employed to treat depression and may lead to complete recovery in only 50% of clinically depressed patients but causes many adverse effects. Thus, scientists are increasing their interest in research towards the utility of medicinal plants for antidepressant activity. Several medicinal plants and its derived medicinal products have been reported to exert antidepressant action in different animal models by the combined effect of their phytoconstituents. In the brain, the alteration in level of various endogenous molecules likes noradrenaline (NA), acetylcholine (Ach), serotonin (5-HT), dopamine, glucocorticoid, γ-aminobutyric acid (GABA), corticotrophin-releasing hormone (CRH) and hippocampal volume are responsible for depression. Therefore, most medicinal plants through synaptic regulation of serotonin, noradrenaline, and dopamine, overcome the altered level of monoamines in the brain and also reinforcing antioxidant defense mechanism, regulate hypothalamic-pituitary-adrenal axis activity and reducing inflammatory mediators. So, herbal medicines are widely used in contrast to allopathic or...
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Posted by admin on Dec 31, 2019 in |
A simple, rapid, precise, sensitive and reproducible Reverse Phase High-Performance Liquid Chromatography (RP-HPLC) method has been developed for the quantitative analysis of Diclofenac sodium in the chocolate dosage form. Chromatographic separation of Diclofenac sodium was achieved on waters alliance-e2695, by using waters symmetry C18, 150 mm × 4.6 mm, 3.5 µm, column and the mobile phase containing 0.1% formic acid & ACN in the ratio of 30:70% v/v. The flow rate was 1.0 ml/min; detection was carried out by absorption at 275 nm using a photodiode array detector at ambient temperature. The calibration curve was linear over the range of 5-75 µg/ml. The number of theoretical plates and tailing factor for Diclofenac sodium was NLT 2000 and were not more than two, respectively. The proposed method was validated according to ICH guidelines. The method was found to be simple, economical, suitable, precise, accurate & robust method for quantitative analysis of Diclofenac sodium and study of its...
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Posted by admin on Dec 31, 2019 in |
In this research, ciprofloxacin adsorption (CIP) onto graphene oxide synthesized with Fe3O4 (Fe3O4-GO) was applied via various adsorbent dose, contact time, temperature and initial CIP concentration. The results showed that the percentage removal of CIP decreases from 98.1 to %77.4, as the CIP concentration increases from 25 to 200 mg/L. Also, the amount of CIP adsorbed per unit mass of adsorbent increased from 49.25 to 309.6 mg/g with increasing in CIP concentration from 25 to 200 mg/L. The results showed that the adsorption was accurately represented by the pseudo-second-order model. Under different temperature, the CIP maximum adsorption on Fe3O4-GO calculated by pseudo-second-order kinetic model and were 197 mg/g (273 K), 191.6 mg/g (288 K), 182.2 mg/g (303 K) and 172.6 mg/g (318 K). Also, the results showed the existence of three steps during the adsorption process. The first stage was the transport of CIP molecule from the adsorbents external surface to the pores of the adsorbent internal structure. The second stage is the transport of CIP molecule from the...
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Posted by admin on Dec 31, 2019 in |
Attempts were made to carry out the laboratory synthesis of non-symmetric mono-, di- and tri- substituted 1, 3, 5-triazines by the action of the electron-donating substituent on 2, 4, 6-trichloro-1, 3, 5-triazines by aromatic nucleophilic substitution reaction mechanism (SNAr reaction) by temperature controlled. The introduction of the amino group (-NH-), ether (-O-) and thiol (-S-) Linker Bridge show more promising antibacterial activity. The yield of newly synthesized compounds was quite well, and their structures were confirmed by using IR, 1H NMR, and Mass spectral...
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