Posted by admin on Dec 31, 2019 in |
Background: Leukemia is the seventh common cancer in Iran, and AML is considered as the most common type. Malnutrition is common among patients with cancer. Vitamin C deficiency has a high prevalence among patients with cancer, which may influence a patient’s survival chance. This study was aimed to evaluate the effect of vitamin C supplementation on nutritional status and serum albumin in patients with acute myeloid leukemia referred to Shariati Hospital in Tehran. Methods: This study was recruited by a randomized selection of 50 patients with AML, including entrance criteria, into 2 groups including the supplement group and control group. The duration of the study was 1 month. Nutritional status was assessed by the PG-SGA questionnaire, body weight, serum albumin status, and 3 days of food record before and at the end of the study. Results: The results of this study have shown that the nutritional status and body weight in the supplementation group have improved significantly (p-value=0.001 and 0.004, respectively). The serum albumin status has increased significantly in...
Read More
Posted by admin on Dec 31, 2019 in |
The objective of this study was to determine the safety of rubber seed oil in terms of toxicity, residual solvent and to develop rubber seed cleansing oil as a makeup remover. The cytotoxicity of rubber seed was determined on human fibroblast cell. It was not cytotoxic to human fibroblast cell at >1000 µg/ml. Rubber seed oil was further examined for the presence of linamarin toxin and determining the solvent residual. FTIR spectrum revealed that there was no presence of cyanide peak and, n-hexane residual was 60.35 ± 1.12 ppm. Based on these results, it was suggested that rubber seed oil was safe to be developed as a product for cosmetic applications. The rubber seed cleansing oil was formulated in various compositions of rubber seed oil (5, 10 and 15%) combined with sorbeth-30 tetraoleate (HLB 11.5) and sorbitan sesquioleate (HLB 3.7) and the ratio of surfactant was 10, 15 and 20% respectively. The most suitable formulation with good physical properties was obtained from 5% of rubber seed oil, and 15%...
Read More
Posted by admin on Dec 31, 2019 in |
Non-alcoholic fatty liver disease (NAFLD) is chronic liver diseases ensuing from excessive fat accumulation in liver attributed to high dietary fat and carbohydrate and lower hepatic activity. It is associated with obesity and high BMI (body mass index). The excess carbohydrate-rich diet activates its conversion to TG (triglycerides), which gets accumulated in adipose and non-adipose tissues in the body. Insulin resistance also plays an important role in its pathogenesis. This work is focused on antioxidant and hypolipidemic potentials of water extract of Pueraria tuberosa (PTWE) in rats with high fat diet-induced non-alcoholic fatty liver disease. NAFLD was induced in rats with a high-fat diet (HFD) for 100 days and grouped into HFD control, HFD+PT 50 mg/100 g bw, HFD+PT 100 mg/100 g bw. Blood triglycerides, cholesterol, glucose, serum glutamate oxaloacetate trans-aminases (SGOT), serum glutamate pyruvate transaminases (SGPT), Superoxide dismutase (SOD), Catalase activity and lipid peroxides (LPO) levels were assessed. The histological studies in the liver were done by H&E staining. PTWE shows the antioxidant properties by decreasing lipid peroxidation...
Read More
Posted by admin on Dec 31, 2019 in |
Oxidative stress and hyperglycemia are two major factors implicated in the development of renal damage. Roots of Raphanus sativus have been reported to possess both ant diabetic and antioxidant activities. So, the present study was aimed to investigate whether aqueous root extract of Raphanus sativus (ARRS) is effective in reversing the renal alterations and oxidative damage against streptozotocin (STZ) induced diabetes in rats. Methods: Rats were divided into five groups of six animals each. Group I is normal control which receives distilled water (p.o). Remaining animals were injected with STZ (60 mg/kg; i.p) to induce diabetes. 3 days after injection, animals with blood glucose levels greater than 250 mg/dl were divided into 4 groups: Group II received distilled water, Group III received glibenclamide (GLB; 5 mg/kg) and group IV and V received 100 and 200 mg/kg of ARRS at oral route for 8 weeks. At the end of 8 weeks, blood glucose, glycated hemoglobin (HbA1c), albumin, creatinine, blood urea nitrogen (BUN), malondialdehyde (MDA) and glutathione (GSH) levels were analyzed...
Read More
Posted by admin on Dec 31, 2019 in |
Background: Leukemia is the seventh common cancer in Iran, and AML is considered as the most common type. Malnutrition is common among patients with cancer. Vitamin C deficiency has a high prevalence among patients with cancer, which may influence a patient’s survival chance. This study was aimed to evaluate the effect of vitamin C supplementation on nutritional status and serum albumin in patients with acute myeloid leukemia referred to Shariati Hospital in Tehran. Methods: This study was recruited by a randomized selection of 50 patients with AML, including entrance criteria, into 2 groups including the supplement group and control group. The duration of the study was 1 month. Nutritional status was assessed by the PG-SGA questionnaire, body weight, serum albumin status, and 3 days of food record before and at the end of the study. Results: The results of this study have shown that the nutritional status and body weight in the supplementation group have improved significantly (p-value=0.001 and 0.004, respectively). The serum albumin status has increased significantly in...
Read More