Posted by admin on Oct 31, 2020 in |
The study was aimed to justify the traditional claim of fruits of Sesbania grandiflora (Leguminosae) as a medhya rasayana. Dementia was induced with chronic administration of a high fat diet for 90 days. Petroleum ether, benzene, chloroform, acetone, ethanol extracts of fruits of Sesbania grandiflora were evaluated for cognition-enhancing activity in high-fat diet-induced dementia in rats using an elevated plus maze and biochemical estimation of brain AchE and cholesterol level. Piracetam (200 mg/kg p.o.) as standard drug. Transfer latency (TL) was observed in HFD induced rats using EPM which showed significant increase (p<0.01) in TL as compared to the normal control group. The high-fat diet-induced rats showed a significant increase (p<0.01) in AchE and cholesterol levels as compared to normal control. Whereas petroleum ether extract treated rats showed a significant increase (p<0.01) in AchE and cholesterol level. Treatment with benzene, chloroform, acetone ethanol extract of Sesbania grandiflora fruits inhibited the rise in brain acetylcholinesterase and cholesterol level. These observations established traditional claim, and thus Sesbania grandiflora could be memory...
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Posted by admin on Oct 31, 2020 in |
The novel coronavirus (COVID-19) outbreak has covered almost 185 countries worldwide, causing infection to 32, 50,000 people and the death of approximately 2, 30,000 people to date. World Health Organisation (WHO) has declared it a pandemic that seems to be unstoppable as no vaccine or drug is available as of now to kill the virus. Several research labs are trying to develop a vaccine against the virus as soon as possible. Several drugs, like a combination of hydroxychloroquine and azithromycin, have been shown to be beneficial in COVID-19 infected patients. In-silico experiments suggest that methylcobalamin and valproic acid can reduce virus titer and thereby reducing the severity of the infection. BCG vaccine may provide immunity against the infection of coronavirus. As there is a strong correlation between the immune system of the infected person and the virulence of coronavirus, any therapy which could help in boosting the immune system shall be of prime importance. Hence, the efficacy of convalescent plasma therapy has been tried in COVID-19 infection, thinking that...
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Posted by admin on Oct 31, 2020 in |
The present investigation was aimed at synthesis, characterization and in-vitro antibacterial and anticancer activities of synthesized gold nanoparticles using bark extract of Ceiba pentandra (L.) Gaertn. The synthesized AuNPs were confirmed by a UV-vis spectrometer through observing the surface plasmon resonance peak at 535 nm. Various other techniques, such as Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Selected area electron diffraction (SAED), and High- resolution transmission electron microscopy (HR-TEM) were also employed in the demonstration of the AuNPs properties. The synthesized gold nanoparticles were highly stable, spherical in shape, while other particles had irregular circles without uniform edges with average sizes of 20-48 nm. By using the agar well diffusion method, an attempt was made to evaluate the antibacterial activity of the metal nanoparticles against human pathogenic bacteria. AuNPs showed efficient antibacterial activity, which was found to be more pronounced against gram-negative bacteria than gram-positive ones. Through MTT assay, cytotoxicity effects of the synthesized AuNPs were tested against HCT-116 colon cancer cell lines with an IC50 inhibitory concentration...
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Posted by admin on Oct 31, 2020 in |
In this study, the pharmacognostic and phytochemical standardization of tuberous roots of Smilax china L. belongs to the Family Liliaceae was performed in detail. Pharmacognostical standardizations like macroscopical and microscopical studies, powder microscopy, quantitative microscopy, physicochemical analysis, fluorescence study, determination of heavy metal contamination, qualitative and quantitative estimation of inorganic elements, microbial contamination and preliminary phytochemical screening were performed as per WHO guidelines and other standard methods. The pharmacognostic evaluation was performed in order to create a standard monograph of the plant for identification as well as to detect the adulterants. Macroscopical study of tuberous root showed irregular, cylindrical, curved in shape and brownish-yellow in color. A microscopical study showed cortex, sclerenchyma, elongated parenchyma, starch grains, vascular bundles, fibers and tannin cells. Linear measurements were measured. Physicochemical analysis like ash value (Total ash – 0.5% w/w, acid insoluble ash – 0.06% w/w, water-soluble ash – 0.01% w/w, sulphated ash – 0.08% w/w), extractive value (water-soluble -16% w/w, alcohol soluble – 6% w/w), loss on drying (4.76% w/w), foaming index...
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Posted by admin on Oct 31, 2020 in |
In recent years, most researchers and interesting ones in the field of microbial biofilm documented that nanoparticles like silver, metal ions play a significant role in the biofilm approach. Here i would like to draw your attention to the modern technique in biofilm and the role of nanotechnology in combating medical resistant microbial infection. It is now realized that most bacterially derived sessile communities are capable of forming irreversible biofilms on surfaces and interfaces by embedding themselves deep in a self-generated polymeric matrix. Most of the fungal species that form biofilms do so in a similar manner; Candida and Aspergillus are fungal species of particular interest. The mechanism of biofilm formation depends on environmental stimuli and a series of genetic and phenotypic changes in planktonic cells. To date, five different stages have been suggested during biofilm development, namely, (i) reversible-irreversible adherence, (ii) microcolony formation, (iii) 3D biofilm formation, (iv) maturation, and (v) dissemination. It is believed nanotechnology-based approaches will provide promising advancements to prevent drug-resistant biofilm infections of medical...
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