Posted by admin on Nov 30, 2020 in |
Background: Diabetic postmenopausal women and osteoporosis are both chronic conditions and the relationship between them are complex. Objective: The aims of this study were to assess the socio-demographic factors inflicted in Diabetic postmenopausal women with Osteoporosis condition. Method: A Prospective, comparative and interventional study with a convenient sample of 520 Diabetic postmenopausal subjects were recruited from both inpatient and outpatient: Orthopedic, General Medicine and Obstetrics and Gynecology departments in Malla Reddy Hospital, measuring Bone Mineral Density (BMD) at the heel bone using QUS. In addition, tabulated self – reported data forms, about the socio-demographic details of subjects were collected. Results: The QUS measurements at the culmination of the study deduced that 520 Diabetic postmenopausal women posed a high risk of anomalous BMD were 17% (n=89), whereas Low risk of anomalous BMD accounted for 61% (n=317) and No risk accounted for 22% (n=114), out of validated subjects. The socio-demographic and osteoporotic conditions were illustrated. There were significant differences in QUS-score (normal BMD, Osteopenia and osteoporosis) patient demographic details like current...
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Posted by admin on Nov 30, 2020 in |
Zinc Ferrite nanoparticles were prepared by chemical co-precipitation method, using PEG as the capping agent. The synthesized materials were annealed at different temperatures such as 400, 500, 600, 700 and 800 °C and the structural characterization studies were conducted by X-Ray Diffraction (XRD), Fourier Transform Infrared Spectrometer (FTIR), UV-Visible Spectro-scopy and Field Emission Scanning Electron Microscopy (FESEM). On heat treatment of the as prepared samples, crystallite size was observed to increase from 5 nm-22 nm. XRD pattern confirmed the single crystalline phase of developed particles. It was observed that the particle size and X-ray density of the annealed ZnFe2O4 nanoparticles linearly increased with increase in annealing temperature and decrease in lattice parameters. The calculated micro strain values were found to be decreasing with increasing annealing temperatures. The nanoparticle size was confirmed using SEM measurements. Furthermore FTIR mapping confirmed the presence of ZnFe2O4 nanoparticles. The calculated band gap (Eg) of zinc ferrite nanoparticles decreases with increase in temperature. The antibacterial activity of ZnFe2O4 nanoparticles was studied against gram negative E-coli...
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Posted by admin on Nov 30, 2020 in |
Lansoprazole and Domperidone, used as Proton pump inhibitor and antiemetic agents, especially for disease related to gastric ulcer. The purpose of the research was to improve aqueous solubility of drugs by β-CD using a different method, and perform phase solubility study of both drugs using β-CD and calculate Ks, and ∆Gt. Prepare Complex of LAN and DOM with β-CD using different methods like physical mixture, kneading and co evaporation. Complexes were evaluated for drug content. Based on characterization and dissolution study, kneading method based complex was optimized and tablet prepared using different superdisintegrants like Sodium Starch Glycolate, Cross Povidone, Cross Carmellose Sodium as a synthetic super disintegrating agent and Isphagula, Banana powder and Mango powder as a natural super disintegrating agent. Prepared tablets were evaluated for pre-compression and post-compression parameters such as hardness, friability, disintegration time, wetting time, dissolution study and accelerated stability study. Prepared tablets loaded with complex were compared with a marketed tablet for dissolution study. Optimized complex molar ratios for both drugs were 3:1 and have...
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Posted by admin on Nov 30, 2020 in |
The present study describes the anti-implantation activity of Thespesia populnea bark extracts (ethanol, ethyl acetate, and aqueous)on female albino rats. Extracts were tested for possible anti-implantation activity in albino female rats of the proestrus cycle after overnight cohabitation with males of proven fertility. The drugs were administered to pregnant female rats from day 1 to 7th day of pregnancy. On the 8th day, the rats were laparotomies under light anesthesia, and the numbers of implantation sites were counted, and the reproductive hormonal levels were assessed. The present results revealed that the short term treatment of T. populnea bark extracts reduced the number of implantation sites in the uterus. It also significantly altered the reproductive hormonal level by increasing FSH and LH level and decreasing progesterone, prolactin, and estradiol level. Thus, it is concluded that T. populnea extracts possess significant anti-implantation...
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Posted by admin on Nov 30, 2020 in |
The present investigation was carried out to isolate, characterize, and to study the antagonistic properties of the endophytic microbes from leaves, bark, flower, and fruits of Myristica malabarica. Standard protocols were followed for the isolation and characterization of bacterial and fungal endophytes. Altogether 16 endophytic fungal isolates and three bacterial isolates were isolated from 51 different plant segments of M. malabarica. Three fungi were identified as Aspergillus sp., Penicillium oxalicum, and white sterile mycelium. Bacterial isolates were Gram-positive and Gram-negative cocci and Gram-positive cocco-bacilli. Antagonistic activities of these organisms were tested against Sclerotium rolfsii. Compare to bacterial isolates, fungal endophytes showed good activity. The isolated endophytes were subjected to an abiotic stress tolerance study against a different range of salt and temperature in which all the three endophytic fungi showed very high growth activity only at 25 °C and 37 °C and failed to grow in other temperatures. Fungal isolates showed good amylase, cellulase, and pectinase activity, whereas bacterial isolates exhibited varied activity with respect to...
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