Posted by admin on Nov 30, 2020 in |
The objective of the present study was to develop Empagliflozin and Metformin hydrochloride extended release tablets, comprising immediate release empagliflozin and extended release metformin hydrochloride in a single tablet. Wet granulation process was employed to develop extended release part metformin hydrochloride. Impact of various formulation variables in extended release part was assessed using statistical interpretation such as analysis of variance. A 32 (two factor, three level) factorial design was employed to study the effect of independent variables (binder concentration [sodium CMC] and ER polymer [HPMC K100M CR/polyethylene oxide/carbopol] concentration)on dependent variables (drug release at 1, 4 and 10h). Optimization was done by fitting experimental data to the software program (design expert). The design space for formulation variables and its influence on drug release was developed. In-vitro release data observed from the optimized formulation was fitted into various kinetic equations. Extended release part drug release was extended for 12 h following zero order kinetics and non-fickian diffusion process. Extended drug delivery system of empagliflozin and metformin hydrochloride extended release tablets...
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Posted by admin on Nov 30, 2020 in |
In today’s modern lifestyle, there is an increase in the development of various instant food products. To meet consumer requirements, the food choice will depend on several factors. The present study was aimed with the objective to formulate a value-added instant soup mix with nutritional and sensory charac-teristics. Further, the prepared instant soup mix was subjected to antioxidant and shelf life studies. Three different combinations (A-I, P-I and N-I) were prepared. The coefficient of friction (COF) was minimum for glass surface and maximum for plywood surface for all three products. The results of the moisture ranged from (6.82-7.99%), had different levels of ash content ranged from (7.40-12.49). The concentration of protein of sample NI (28.62%) was having the highest compared to PI (21%) and AI (19.36%). The carbohydrate content was found to be high in A1 (55.06%) compared to NI (46.55) and PI (44.98). The crude fiber, fat and saturated fat, and mineral contents are comparable with the three combinations. High mineral content was observed in NI sample compared...
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Posted by admin on Nov 30, 2020 in |
Objective: A new, simple, sensitive, and economical UV spectro-photometric method was developed for the simultaneous analysis of Adapalene and Dapsone in pharmaceutical formulation. Method: This UV method was developed with Tetrahydrofuran and Distilled water as solvents. The wavelengths selected for analysis in the present method were 237 nm and 293 nm. The method was validated as per ICH guidelines. Results: The method was validated for linearity, accuracy, precision, specificity and robustness. Linearity was found to be within the concentration range of 0.05-0.25 µg/ml for Adapalene and 2.5-12.5 µg/ml for Dapsone. Accuracy for the method was determined by recovery studies. The % drug recovered was found to be 99-102% w/w. The % RSD values of repeatability and intermediate precision were found to be less than 2, providing method was precise in nature. From all these studies it was observed that there was no interference of excipients from the formulation during the analysis. Conclusion: The advantages of this method for analytical purposes lie in the rapid determination, its cost-effectiveness, easy preparation...
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Posted by admin on Nov 30, 2020 in |
Background: Leukocytes play an important role in tissue apoptosis as scavengers and vital components of inflammation, which has been generated during ischemia-reperfusion injury. The present study aimed to investigate the cerebroprotective potential of naringin through anti-inflammatory mechanism. Methods: Cerebral infarction was induced through bi-lateral common carotid artery occlusion for 30 min and 4 h reperfusion in rats. Cerebral infarction, number of leukocytes/cu.mm, and inflammatory markers (TNF α, IL-6 and IL-10) were measured in ischemic rat brain. Results: Percentage of infarction, the number of leukocytes/cu.mm, inflammatory markers (TNF-α, IL-6) and myeloperoxidase were significantly increased, and IL-10 levels were significantly decreased in ischemia-reperfusion injury rats relative to sham control rats. Percentage of infarction, the number of leukocytes/cu.mm, inflammatory markers TNF-α, IL-6, and myeloperoxidase were significantly decreased and IL-10 levels were significantly increased in naringin treated rats relative to ischemia-reperfusion injured rats. Conclusion: This study indicates that infiltrating leukocytes and inflammation plays a key role in cerebral ischemia- reperfusion injury and naringin alleviate the inflammation and infiltrating...
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Posted by admin on Nov 30, 2020 in |
The study aims to investigate the antioxidant and antidiabetic activity of Leucaena leucocephala ethanol leaf extract (LLME). L. leucocephala leaves extraction was carried out by the maceration method. Phytochemical analysis was performed using standard analytical procedures. Diphenyl picrylhydrazyl (DPPH) radical and 2, 2’-azinobis (3-ethylbenzathiazoline-6-sulfonic acid) (ABTS) radical scavenging assay; α-amylase and α-glucosidase inhibition assays were performed. The extraction yield of LLME by maceration was 65%. The phytochemical screening confirmed the presence of alkaloids, monosaccharides, proteins, amino acids, steroids, flavonoids, glycosides, tannins, and saponins. The total phenol content of LLME was 970 mg of GAE/g, and total flavonoid content was found to be 550 mg of QE/g. In DPPH and ABTS assay LLME showed good antioxidant activity (IC50: 11.21 ± 0.2 and 11.87 ± 0.05 µg/mL) when compared to the standard drug, ascorbic acid (IC50:11.09 ± 0.05 and 11.01 ± 0.09 µg/mL). Similarly, in α-amylase and α-glucosidase inhibition assay, acarbose revealed enzyme inhibition activity with an IC50 value of 12.02 ± 0.02 and 12.11 ± 0.02 µg/mL while LLME showed...
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