Posted by admin on Jun 30, 2020 in |
A number of N-(5-p-tolyl-1,3,4-thiadiazole-2-yl) benzamide derivatives were synthesized from aromatic acid. The antibacterial activity of these newly synthesized N-(5-p-tolyl-1,3,4-thiadiazole-2-yl) benzamide derivatives against Gram-positive bacteria and Gram-negative bacteria was also studied using the minimum inhibition concentration method. The synthesized compounds were showed better results for antibacterial evaluation against gram-positive (Staphylococcus aureus, Bacillus subtilis), gram-negative (Escherichia coli, Pseudomonas aeruginosa) and fungal strains (Candida albicans, A. niger) and were found to be good antibacterial and antifungal agents. Most of the derivatives showed significant antibacterial and antifungal activity against standard. Compared to other methods, the advantageous features of this methodology are operational simplicity, including excellent yields and short reaction time. The developed synthetic protocol represents a very simple and easy to handle for the synthesis of substituted N-(5-p-tolyl-1,3,4-thiadiazole-2-yl) benzamide...
Read More
Posted by admin on Jun 30, 2020 in |
This paper investigates the determination of trace metals named Chromium and Lead set down in the soil as well as in the groundwater due to the tanning industries area of Ranipet town, Vellore city. The tanneries discharge untreated tannery effluents, which get mixed with the soil, water of the Palar river, and underground in this area. The determination of metals was performed for the soil that was collected from the agricultural land adjacent to the Palar River, which bears untreated tannery effluents at pre-monsoon and post-monsoon seasons. The soil samples were collected from three different layers of different depths in these agricultural lands. The first layer is the superficial layer (0 – 10 cm); the second layer is 30 – 40 cm, and the other is 60 – 70 cm below from the surface level. The soil is affected by the untreated effluents through the deposition of heavy metals. The metals might be deposited into the plants and vegetables grown on that agricultural soil, which disturb human health. An extreme...
Read More
Posted by admin on Jun 30, 2020 in |
The present study involves the formulation and evaluation of floating in-situ gel containing piroxicam for the treatment of arthritis. In the FTIR and DSC study for compatibility of piroxicam with polymers, there are no significant changes observed so it is confirmed the absence of drug-polymer interactions. The gastric floating in-situ gel was prepared by using Sodium Alginate, HPMC K 200 M & other ingredients. The prepared situ gel of piroxicam was evaluated for pH, gelling capacity, floating lag time, total floating time, drug content, viscosity, in-vitro drug release. An optimization study was carried out by using was 32 factorial designs to find the effect of independent variables, i.e., amount of Sodium Alginate (X1) and HPMC K 200 M (X2) on dependent variables i.e., floating lag time & % CDR. The results showed that all the formulations exhibited a very short floating lag time. Most of the formulations floated within 1 min. All the formulations exhibited a basic pH in the range of 6.7 to 7.9 which is suitable for...
Read More
Posted by admin on Jun 30, 2020 in |
Bacopa monnieri, Tinospora cordifolia, and Evolvulus alsinoides are conventional Ayurvedic floras that are useful in the various neuropharmacological ailment. This research focused on the effect of ethanolic extract of Bacopa monnieri (BME), Tinospora cordifolia (TCE), and Evolvulus alsinoides (EAE) were evaluated alone and in a combination of extracts (CEPs) by using scopolamine-induced oxidative stress in rats. Tissue homogenates were prepared, an indicator of Superoxide Dismutase (SOD), Glutathione (GSH), Lipid peroxidation (LPO), Catalase (CAT) and Acetylcholinesterase (AChE) enzyme activities were estimated in the rat brain. Due to scopolamine treatment, enhanced LPO and AChE level but reduced SOD, CAT, and GSH levels in rats brain were observed. Rats treated with BME, TCE, EAE, and their CEPs [CEP-1 (EAE and BME), CEP-2 (TCE and BME), CEP-3 (TCE and EAE) and CEP-4 (BME, TCE, and EAE)] at 200 mg/kg, provided significant effect against scopolamine because these extracts decreases LPO, AChE level and restored SOD, GSH, and Catalase levels in rats brain. The CEPs produced significant effects in comparison to BME, TCE, and EAE....
Read More
Posted by admin on Jun 30, 2020 in |
Objectives: This work aimed to formulate and evaluate amikacin, fourth-generation fluoroquinolone antibiotic agent containing an in-situ gelling system based on sol-to-gel transition for ophthalmic delivery to overcome the problems of poor bioavailability and therapeutic response exhibited by conventional formulations based a sol-to-gel transition in the cul-de-sac upon instillation. Methods: In the present work, poloxamer 407 as a temperature-activated gelling agent and gelrite as an ion activated gelling agent were used in combination to prepared ion-sensitive and temperature-sensitive ophthalmic in-situ gel. The prepared formulations were evaluated for the parameters like pH, appearance, drug content, in-vitro gelation study, viscosity, in-vitro release study, sterility test, and stability studies. Results: In this study, the release profile depends on the concentration of gelrite and poloxamer 407. The selected formulation showed sustained release for a period of 10 h. Thus it showed increased residence and contact time with the eye. The draize test was performed with an optimized formulation for eye irritation test. It was found to be non-irritant to the rabbit eye. The in-situ...
Read More
