Posted by admin on Apr 30, 2020 in |
Lantana camara Linn. is an important ethnomedicinal plant with several medicinal properties. It is widely used in the traditional medicinal system as carminative, anti-inflammatory, antipyretic and respiratory system infections. The present investigation was carried out to determine the qualitative analysis of phytochemical screening and the presence of bioactive compounds from the hexanolic extract of Lantana camara leaves using GC-MS. The GC-MS analysis of hexanolic extract reported the presence of cis-Caryophyllene, caryophyllene oxide, isophytol acetate, 13-docosenamide, (Z) – and Squalene as major compounds. The presence of terpenes in extract confirms its application as anti-cancer, antioxidant and anti-microbial agents along with traditional medicine...
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Posted by admin on Apr 30, 2020 in |
Chronopharmacology is the science that is of different types in the pharmacological activities of different treatment over organic timings and endogenous balance. Chronotherapeutics is the science which increases the creativity and security of prescriptions by balancing their fixations during the 24 h synchronizing with regular routine determinants of disease. Chronopharmacokinetics again manages time and predictable changes in pharmacokinetic parameters of medicines. For example manages the examination of the fleeting changes in the assimilation, dissemination, digestion, and disposal because of the time of planning of the treatment. Circadian rhythms are especially notable in drugs. Biologic rhythms are the endogenic nature of circadian. Chronopharmaceutics is depicted as a part of pharmaceutics gave to the plan and evaluation of medication prescribing structure that discharges a bioactive specialist at a musicality that preferably coordinates the natural prerequisite of given disease treatment. The fresher treatment conveyance structure that is structured with the chronopharmacological approach holds incredibly long for conveying better patient consideration regarding viability, resistance, and wellbeing parameters of the...
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Posted by admin on Apr 30, 2020 in |
Diltiazem HCl is a calcium ion channel inhibitor. The capacity to hinder the convergence of calcium ion present in of cardiac and vascular smooth muscle during membrane depolarization is accepted to be its therapeutic impact. It is broadly utilized in the treatment of a few kinds of cardiovascular disorders. For accomplishing better drug viability, unwavering quality success within the leading edge pharmaceutical structure, and targeted analysis, sustained-release drug delivery has touched toward changing into gauges. The biggest offer of drug delivery frameworks, for example, up to 80% of all the medication records to the OSRDD (Oral Sustained Release Drug Delivery). Sustained releases tablets of diltiazem HCl was planned to utilize Hydroxypropyl methylcellulose (HPMC 643), and povidone in various ratios, the extended-release conduct of fabricated tablets were then assessed. Sustained-release diltiazem HCl tablets were made by the direct compression method. The formulation was streamlined based on various tablet properties and drug release design in-vitro release profile. The subsequent formulation created tablets with required hardness, weight uniformity, and friability. The aftereffect...
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Posted by admin on Apr 30, 2020 in |
The phytochemical analysis of ethanol extract of Scurrula parasitica showed positive results for alkaloid, saponins, tannin, terpenoids, flavonoids, phenol, reducing sugar and phytosterols whereas glycoside is found to be absent. Total phenol and flavonoid contents were evaluated and found to be total phenolic compounds (101.9-379.1 µg/g tissue) and total flavonoids (72-174.1 µg/g tissue), respectively. The free radical scavenging activity of ethanol extracts of Scurrula parasitica (Loranthaceae) was determined to validate the medicinal potential of the plants. The antioxidant activity was performed by 2, 2-Diphenyl-1-picrylhydrazyl (DPPH) assay and ABTS + cation. The optimum concentration for both DPPH and ABTS was obtained at 100 µg/ml with an IC value of 53.28100 µg/ml and 160.8100 µg/ml, respectively. Therefore, the high content of both phenols and flavonoids might contribute to the anti-oxidative...
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Posted by admin on Apr 30, 2020 in |
Various nitrogenous heterocyclic compounds like 1, 8-naphthyridine-3-carboxamide are synthesized and studied for their wide range of biological activity. Versatile activity of this scaffold will increase interest from innovator on significance of their antibacterial activity and will influence their role in drug discovery. Synthesis and Antibacterial evaluation of ten derivatives of 1-ethyl-4-oxo-1, 4-dihydro-1, 8-naphthyridine-3-carboxamide (SD-1 – SD-10) is discussed in this paper. Synthesis of novel 1, 8-naphthyridine-3-carboxamide derivatives starting from substituted pyridine with ethoxy-methylenemalonate ester by cyclo-condensation reaction affords 1,8-Napthyridine-3-carboxylate at high temperature and at specific reaction condition. All 1, 8-napthyridine-3-carboxylate compounds were treated with an excess of substituted aniline with mild reaction conditions. All the compounds obtained were purified by using the recrystallization method. Structure confirmation of synthesized compounds was accomplished on the basis of IR, 1H NMR, and MS. The synthesized compounds were tested against bacterial strain, Escherichia coli (Gram-negative) Staphylococcus aureus (Gram-positive). Many of the compounds exhibited significant antibacterial...
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