Posted by admin on Mar 31, 2021 in |
Herbal medicines are in substantial demand in the developed country for primary healthcare because of their high efficacy, safety, and few side effects. Sesbania grandiflora is an ancient plant that belongs to the family Fabaceae. Traditionally, it is used for the treatment of various disorders such as diabetes, anxiety, hepatotoxicity, ulcer, and anti-inflammatory activity. Therefore the present investigation was undertaken to investigate the anti-arthritic potential of Sesbania grandiflora seeds extract against CFA-induced arthritis in experimental animals. The Ethanol extract of Sesbania grandiflora seeds was prepared by liquid-liquid extraction procedure, and phytochemical analysis of extract was done by the different chemical test as well as HPLC. Daily oral treatment of ethanol extract of Sesbania grandiflora and UK-356618 for twenty one days. After nine day of CFA administration improve the body weight and attenuated the paw volume, hepatic biomarkers as well as hematological parameters such as hemoglobin, RBC, Hb, WBC, and ESR of experimental animals. Finding of the current investigation demonstrated that the ethanol extract of Sesbania grandiflora along with UK-356618...
Read More
Posted by admin on Mar 31, 2021 in |
In the view of an extensive literature survey that revealed the anticonvulsant profile of 1,4-dihydropyridines and 1,3,4-Thiadiazole, we have coupled these two moieties with the aim of achieving an enhanced anticonvulsant effect. In present investigation some of ethyl-1-((5-amino-1, 3, 4-thiadiazol-2-yl) methyl)-5-ethyl-2, 6-dimethyl-4-substituted phenyl-1, 4-dihydro-pyridine-3-carboxylate derivatives are synthesized through four steps. A greener approach is employed by using Chloramine-T as an efficient and safer oxidative catalyst for the synthesis of Thiadiazole and the use of the Microwave technique for accelerating the chemical reactions. The structures of the newly synthesized compounds were confirmed on the basis of IR, 1H-NMR, and Mass analyses. An acute toxicity study was done to determine LD50 of the newly synthesized compounds. Some of the synthesized compounds were evaluated for their anticonvulsant effect by PTZ induced convulsions method. Statistical testing was done by one-way ANOVA followed by Dunnett’s test. The compounds F123 and showed the highest percentage of protection against convulsions at the dose of 15 mg/kg among the evaluated compounds compared to...
Read More
Posted by admin on Mar 31, 2021 in |
Objective: This research article aims to formulate and evaluate orodispersible tablets (ODTs) for Vinpocetine, a nootropic drug used for improving brain functions and cerebral blood flow. This will provide a convenient way for taking medication for dysphagia patients and therefore improve compliance. Methods: Vinpocetine ODTs were prepared by using superdisintegrants. A full mixed 31×41 factorial design was applied to evaluate the effect of two independent variables, namely superdisintegrant type (crospovidone, croscarmellose sodium and sodium starch glycolate) and superdisintegrant concentration (2.5, 5, 7.5, and 10%) on four responses namely friability, disintegration time, wetting time and dissolution percent after 5 min. Compatibility study was carried out using differential scanning calorimetry. Various physico-chemical properties were measured, and in-vivo pharmaco-kinetic study for a selected formula was performed against a conventional tablet market product. Results: Results showed that formulae ingredients were compatible. Crospovidone showed the shortest disintegration time and wetting time. Friability was less than 1%in all formulae, and dissolution percent after 5 min was greater than 80% in all formulae. Statistical evaluation of...
Read More
Posted by admin on Mar 31, 2021 in |
Cancer, according to WHO, is a generic terminology for a group of diseases that are characterized by abnormal growth of cells. This uncontrolled, abnormal growth is beyond the natural boundaries of normal cell growth, which can then metastasize to adjoining or distant sites of the body and/or to the organs. Cancer is the second most leading cause of mortality and has resulted in 9.8 million deaths in 2018 alone. Efforts to explore newer anticancer drugs have significantly increased in recent years. Appropriate preclinical experimental screening models can help us apprehend the pathogenesis, complications, and testing of various therapeutic agents. Both in-vitro, as well as in-vivo models are available for the screening of compounds. A preclinical screening model should have a high sensitivity and reproducibility. This review summarizes some conventional as well as newer experimental screening models used for preclinical screening of test compounds for the treatment of...
Read More
Posted by admin on Mar 31, 2021 in |
This study was conducted to evaluate gastroretentive metronidazole tablets formulated using Brachystegia eurycoma gum as a matrix. The gum was isolated from powdered dried Brachystegia eurycoma seeds. Gastroretentive metronidazole tablets were produced by direct compression technique using Brachystegia eurycoma gum, sodium carboxymethylcellulose, or their combination as the matrix. Sodium bicarbonate was used as a gas generating agent. The tablets were evaluated based on hardness, friability, weight uniformity, drug content, swelling studies, buoyancy lag time, and total buoyancy time. Hardness ranged from 4.57 ± 0.053 to 11.81 ± 0.90 Kgf. None of the tablets deviated from the mean tablet weight by more than ± 5%. The friability of the tablets was within 0.28 to 1.00% except for formulation MF1 that was 1.93%. Drug content was between 91.51% and 109.53%. The buoyancy lag time was between 2.35 and 20.15 min, and tablets from all the formulations maintained a total buoyancy time of above 12 h. Eighty percent (80%) of metronidazole was released from formulations MF1 to MF5 after 6, 9, 7,...
Read More
