Posted by admin on Feb 28, 2021 in |
Botanical name of coriander is Coriandrum sativum Linn. Coriandrum sativum belongs to the family Umbelliferae which is a highly reputed ayurvedic medicinal tree commonly known as Dhania. Essential oils, flavonoids, fatty acids, and sterols have been isolated from different parts of C. sativum so far. The phytochemical analysis of both methanol and AgNP’s extract was evaluated. Results revealed the presence of alkaloids, flavonoids, diterpenes, phenol, and phytosterol in the methanol extract, and AgNP’s extract contained flavonoids, phenols, and phytosterols. The antioxidant activity of both the extract was measured by the ability to scavenging DPPH, phenols, flavonoids, metal chelating, FRAP and was compared with suitable standards. These assays showed that both the extracts exhibit significant antioxidant activity. The highest percentage of inhibition was given by methanol extract when compared to standards, while in DPPH assay, AgNP’s showed the highest inhibition compared to methanol extract. The antibacterial activity of different concentrations of both extracts of C. sativum was determined against different bacterial strains. The methanol and AgNP’s extraction showed maximum inhibition...
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Posted by admin on Feb 28, 2021 in |
The waste generated from the textile industry is used for the production of biogas under the anaerobic digestion method. This study investigated the effect of various parameters such as Temperature 27 °C – 31 °C, pH 8-10, Inoculum concentration 35-55 ml on the textile dye with rice husk by the Agaricus heterocystis for biogas production using Response surface methodology. Maximum biogas yield 93 ml was obtained under the optimized condition of pH 9, Temperature 29 °C, and Inoculum volume 45 ml. The modified Gompertz model was used for maximum biogas production (1140 ml) from reactor 1 of textile dye (100 ml), rice husk (20 g), and inoculum volume (45 ml). The maximum biogas production (350 ml) was obtained under the optimized condition of Incubation time 144 h; Dye 100 ml/L and Rice husk 20 mg/L under the classical method. Produced biogas was confirmed and analyzed the composition: Methane – 78% and Carbon dioxide – 13% by Gas Chromatography (GC) method. The present study provided an efficient method for textile...
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Posted by admin on Feb 28, 2021 in |
The study purpose is to further enhance the rate of dissolution for poorly water-soluble drug Nicardipine Hydrochloride by dissolving NH in surfactant, Co-surfactant, and oil; phase diagram was plotted by using oil (Capmul MM C8 EP), surfactant (Labrasol), and co-surfactant (PEG 400) through which a region called microemulsifying region was obtain. The batches were optimized by holding a 3-factor and 3-level Box–Behnken design for knowing the impact of independent and dependent variables. For the selection of dependent responses, the PCA technique was employed for examining significant variables. The Liq-SMEDDS were characterized for % T, zeta potential, emulsification time, particle size, cloud point, drug content, etc. The optimized batch shows an emulsification time of 32.73 sec and particle size as 97.745 nm. In-vitro drug release shows the faster release of drug as 90.37% within 15 min. S-SMEDDS were obtained by using Neusilin as an adsorbent in Optimized formulation. DSC of solid SMEDDS showed no peak indicates that the drug was completely converted into an amorphous form or was present in...
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Posted by admin on Feb 28, 2021 in |
Macro and microelements are integrally linked to hormones, vitamins, amino acids, and enzymes in the human body. They affect the normal course of physiological processes. Some medicinal plants contain substantial contents of micro-and macro-elements, which makes it possible to use them purposefully for the prevention and treatment of various diseases. The target of the research was samples of G. macrophylla herb harvested and procured in the Republic of Tyva. The aim of this research provided a quantitative determination of the elemental composition in the herb of G. macrophylla Pall. as a possible source of macro and microelements. The determination was carried out with the atomic absorption spectrophotometry technique. As was discovered, Fe, Mn, Zn, Cu, Cr, Se, Mo, B, and Ag are present in the G. macrophylla herb. The maximum admissible contents of heavy metals in the specimen under study did not exceed the limits recommended for the quality assessment of herbal raw...
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Posted by admin on Feb 28, 2021 in |
Hypertension is the most life-threatening disease amongst all lifestyle diseases. So, there is always a need for such a dosage that can release the drug for a long period from a single dose which will reduce the dose burden for the patient. The propranolol HCL is a non-selective beta-adrenergic blocking agent extensively used in various cardiovascular diseases. In the present study hydrogel matrix tablets of anti-hypertensive drug, Propranolol HCL were prepared and evaluated. The HPMC was used as a rate retarding polymer, whereas Talc was used as filler, and magnesium stearate was used as a lubricant. The present study results point out that the rate of propranolol HCL release from HPMC matrices is mainly controlled by the drug: HPMC ratio. When the concentration of HPMC was enhanced, the release of the drug from the matrix tablet was retarded. The prepared hydrogel matrix tablets were evaluated for various parameters like Angle of Repose, Bulk Density, Tapped Density, Carr’s Index, hardness, friability, uniformity of weight, uniformity of drug content, and disintegration...
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