Posted by admin on Feb 28, 2021 in |
Objects: In the present study the anti-ulcer activity of Saccharum officinarum fresh juice was investigated in the chemical-induced ulcer. The efficacy of the plant based juice was compared with standard reference anti-ulcer drug Ranitidine. Methods: The fresh juice collected from the plant of S. officinarum. Firstly, washes the sugarcanes well and peel the outer layer of the cane with a big knife. Then cut them into small pieces and squeeze them for extraction. Take out the extract along with them in a big container. And then study with chemical-induced ulcer in healthy rats. Result: The modal of absolute 40% ethanol-induced ulcer, oral administration of fresh juice (20ml/kg/bw) dose showed that reduction in ulcer index, collection of gastric juice, free acidity, total acidity, and also shows the pH of gastric juice and all parameters compared with the control group. It was showing a protection index of 55.99% at the dose of 20ml/kg/bw. Ranitidine as reference standard drug and showing a protection index of 63.32% at the dose of 50mg/kg-bw. Conclusion:...
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Posted by admin on Feb 28, 2021 in |
An in-silico attempt to predict rat oral acute toxicity, hepatotoxicity, immunotoxicity, genetic toxicity endpoints, nuclear receptor (NR) signaling, and stress response (SR) pathways of metabolites of synthetic medicine Ranitidine and flavonoids of Musa sp. The metabolites of common flavonoids and synthetic medicine were taken from literature, and the prediction was done by using ProTox-II webserver. The predictive results for the toxicity of these metabolites, N-nitrosodimethylamine obtained the lower LD50 value (26 mg/kg) as highest toxicity of class II, i.e., prescribed as fatal after swallowing ranged between >5 and ≤50, and rest compounds were class IV and V i.e., harmful or may be harmful if swallowing ranged between >300 and ≤2000 and >2000 and ≤5000. None of these were showed hepatotoxic as well as not cytotoxic and mutagenic active, but few were immunotoxic, and all metabolites of synthetic origin and two phytometabolites viz. quercetin-3-glucuronide and 5-O-methylmyricetin were obtained carcinogenic active. In the case of NR signaling pathways and SR pathways, three compounds were active on different parameters. In conclusion, this...
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Posted by admin on Feb 28, 2021 in |
Spices, nature’s gift to mankind are the reservoir of secondary metabolites – alkaloids, flavonoids, saponins, tannins, glycerides, sulfides, and other oxygen/nitrogen compounds that can effectively treat viral infections, bacterial infections, and respiratory problems. Since ancient days they have been used for its anti-inflammatory, carminative, antioxidant, anti-clotting, anti-microbial, anti-pyretic, and cardiotonic properties. In search of identifying a natural therapy for severe acute respiratory syndrome coronavirus (SARS-CoV) infections, this review investigates the pharmacological nature of some commonly used spices (ajwain, asafoetida, black pepper, cinnamon, clove, coriander, fenugreek, garlic, ginger, long pepper and turmeric) with special reference to the mechanism of vasodilatory property. Among the selected commonly used spices, turmeric and ginger especially have been reported to alter the expression of angiotensin-converting enzyme 2 (ACE2) to exert its vasodilatory property. The study could lead to a novel exploration of vaccines/drugs aided with a detailed investigation of individual bioactive compounds as well as their synergic...
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Posted by admin on Feb 28, 2021 in |
Objective: Development of simple, rapid, and accurate UV spectrophotometric method for the estimation of Fentanyl citrate (FC) in a bulk and pharmaceutical dosage form. The proposed method was validated according to the guidelines of the International Conference on Harmonization and the Association of Official Analytical Chemists International. Methods: The method was based on the measurement of absorbance at a wavelength of257.6 nm, λmax of FC in methanol, respectively. Results: The calibration curve of FC was linear in the concentration range of 200-1400 µg ml-1. The mean recovery, the limit of quantification (LOQ) and limit of detection (LOD) for FC were 99.029%, 1.031 µg ml-1and 0.340 µg ml-1, respectively. The method was precise, with a relative standard deviation of less than 2.0 %. For robustness, the factors analyzed did not significantly affect the quantification of FC. Conclusion: The proposed method can be successfully applied for the estimation of FC in a bulk and pharmaceutical dosage...
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Posted by admin on Feb 28, 2021 in |
Medicinal plants play an important role in the development of potent therapeutic agents. In recent years there has been an increased interest in using of herbal medicines. To assess the antioxidative and antitumorigenic efficacy of methanolic extract of bark, fruits, and leaves of Ficus racemosa in Dalton Lymphoma Ascites tumors transplanted Swiss albino mice. The results showed that the cytotoxicity study by Trypan blue assay revealed the concentration-dependent cytotoxic activity of MEFrB, MEFrF, and MEFrL to DLA tumor cells with the fifty percent effective dose (ED50) at 54 µg, 58 µg, and 60 µg, respectively. The MTT assay also showed the cytotoxic effect to DLA tumor cells at the concentration-dependent, and the ED50 was found to be 40µg (MEFrB), 42 µg (MEFrF), and 46 µg (MEFrL) and indicated their antitumorigenic potential. Intraperitoneal transplantation of DLA tumor cells altered the antioxidant balance of the mice liver by significantly decreasing the activities of enzymic antioxidants (CAT, SOD, and GPx) and non-enzymic antioxidants (Vitamin A, E, and C). Administration and co-administration of...
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