Posted by admin on Feb 28, 2021 in |
Bio-pesticides are playing a very important role in controlling mosquitoes and their larvae. In the present scenario, chemical pesticides are causing several side effects on non-target organisms, particularly in men. Moreover, mosquitoes and their larvae become resistant to chemical pesticides; therefore, chemical pesticides are not much more effective. The conventional use of temephos and pyrethrum creates several health hazards in men, especially in upper and lower respiratory disorders, including allergy, asthma, and rhinitis. The plant Hyptis suaveolens is well known for its aromatic properties. Therefore, it was proposed to apply its purified fraction on different strains of mosquitoes for the evaluation of mosquito larvicidal activities. In the present study, identified and authenticated shade-dried whole plant materials were pulverized to get powder, extracted in various solvents through Soxhletion, and percentage yields were noted down. The main phytoconstituents reported in the extract were alkaloids, flavonoids, terpenoids, and tannin in huge amounts. Due to the presence of the pungent smell of flavonoids, terpenoids, alkaloids, and tannin in Hyptis suaveolens, mosquito larvicidal activities...
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Posted by admin on Feb 28, 2021 in |
The secondary metabolites being defensive function in plants, the men also thought of using same to defend the chronic diseases by crud drugs or with some organic aromatic molecules. The phenyl groups and other functional groups are bonded together, forming aromatic organic molecules. These molecules are used in perfumes and medicines. The qualitative and quantitative aromatic and medicinal compounds isolation was carried out from Isodon nilgherricus (Benth.) H. Hara. The qualitative analysis was carried out by various solvent extraction tests, and quantitative analysis was carried out by GC-MS technique. The qualitative analysis of essential oil showed the presence of Butenal <2-methyl-> which has 100% area covered with a retention time of 1.905. Quantitative analysis led to the identification of 32 different compounds from total 38 different peaks. The predominant components of the oil detected were Butyl pentanoate, pentanoic acid (13.60%), Norbornene-2-methonol<endo-5->, bicycle (2.2.1) hept-5-ene-2 methanol (1R-endo) with 5.25% concentration. It was followed by Ethyl 3-hydroxyhexanoate, hexanoic acid, 3, hydroxy-ethyl easter (4.45%), Isobutyl angelate (3.10%), Butanoic acid (2.45%). Butyl pentanoate...
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Posted by admin on Feb 28, 2021 in |
Pomegranate extracts (PGEs) exhibit antioxidative, antiproliferative, and antineoplastic activities. 2-Methoxyestradiol (2-ME), the end metabolite of 17β estradiol (E2), an antiangiogenic agent, inhibits tumor growth. Our earlier investigations demonstrated that aqueous PG extract (PGE) in combination with 2-ME showed antineoplastic effect on Sarcoma-180 tumor cells. The present paper has been oriented to evaluate the antimutagenic or anticlastogenic effect of PGE in combination with 2-ME on normal Swiss albino mice. A comparative evaluation of the antioxidant potential and free radical scavenging activity of ethanolic and aqueous extracts of PG was evaluated by total phenol, flavonoidand Ferric reducing antioxidant power assay (FRAP) content as well as 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity. Ethanolic extract showed more amounts of phenolic compounds, which is a good sign of high antioxidative potentiality. The aqueous extract has high flavonoid content, which dominates the phenolic activity of the ethanolic extract. The aqueous extract has high Ferric reducing power with more scavenging activity in DPPH assay, which promotes the extract to give a protective property. Present results demonstrated that combination...
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Posted by admin on Feb 28, 2021 in |
Present study was aimed to search bioactive functional groups and compounds in the whole animal extract of a marine cnidarians Zoanthus sansibaricus by FT-IR and GC-MS. The methanol extract was used to detect bioactive functional groups and compounds. GC-MS of the animal extract was done, and FTIR analysis was thereafter used to identify the functional groups. The bioactive components were identified based on peak values in the region of infrared radiation. Results of GC-MS revealed eight major compounds like Undecane (13.16%), 2,6-Diisopropylnaphthalene (3.47%), Cyclohexasiloxane, dodecamethyl (6.33%), 6, 11-Undecadiene, 1-acetoxy-3, 7-dimethyl (2.84%), n-Hexadecanoic acid (19.91%), Triphenylphosphine oxide (4.34%), beta. -Sitosterol acetate (43.32%) and Dihydroartemisinin,6-deshydro-5-deshydroxin (6.64%). These are bioactive compounds may act as antimicrobial, antiviral, anti-inflammatory, and antioxidant agents. FT-IR analysis results also indicated the presence of functional groups like N-H (amide group), O-H (carboxylic acid and alcohol), C-H (carboxylic acid and alkanes), and C-F (alkyl halide group) in the...
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Posted by admin on Feb 28, 2021 in |
The novel human coronavirus which has been designated as SARS-CoV2 initially appeared in December 2019 in Wuhan, China causing a respiratory illness called COVID-19. The SARS-CoV2 is a β coronavirus belonging to the family Coronaviridae is a global public health emergency infecting many people all around the world, especially in India with more than 10.8 million cases. Henceforth there is an urgent requirement for a novel drug that counters SARS-CoV2. The present study was intended to evaluate the therapeutic potential of natural products in plants as a potential inhibitor of SARS-CoV2 Mpro (6Y2F, 6Y2G, 6YB7). Molecular docking was performed by Autodock version 4.2, by means of the Lamarckian Genetic Algorithm, to evaluate the possibility of docking. SARS-CoV2 Mpro was docked with twenty-two compounds namely Apigenin, Coriandrin, Curcumin, Catechin, Quercetin, Oleanolic acid, Rosmarinic acid, Ursolic acid, Glucobrassicin, Kaempferol, Gingerol, Naringenin, Carvacrol, Limonene, Eucalyptol, Berberine, Luteolin, Gallic acid, Gedunin, and Nimocinol, and docking was analyzed by Autodock 4.2 and Pymol. HIV drugs, Nelfinavir and Saquinavir, were used as standards for comparison....
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