Posted by admin on Jan 31, 2021 in |
Ethyl4-(2-hydroxy-benzylideneamino) benzoate Schiff base (C16H15NO3), were synthesized and the structure was studied against the bases of X-ray, UV, visible, elemental analysis, 1HNMR, IR and Mass spectroscopy. The crystal structure of the nickel complex has been determined by single crystal X-ray conformed the molecule, which indicate the compound is crystalline in the monoclinic C2 / c with a = 16.0916 (5) Å, b = 6.0315 (2) Å, c =29.0072 (10) Å, α = 90.00°, β= 101.856 (2)°, γ = 90.00°, V= 2755.3 (2) Å3 and Z = 8. Because of intra-molecular hydrogen bond involving the O atom of hydroxy group and N atom of azomethine group; the two benzene rings and azomethine group are practically coplanar. The Cobalt complex was prepared; the structure was characterized in the bases of IR spectra, elemental analysis, UV – visible, and conductance measurements. Also, the biological activity of both Schiff base and its Cobalt complex show that they are biologically...
Read More
Posted by admin on Jan 31, 2021 in |
A simple, reproducible, and efficient reverse phase high performance liquid chromatographic method was developed for simultaneous determination of Lornoxicam and Thiocolchicoside in pure form and marketed combined pharmaceutical dosage forms. A column having Symmetry (C18) (150mm × 4.6mm, 5µm) in isocratic mode with mobile phase containing Methanol: Phosphate Buffer (pH-3.8) (28:72 v/v) was used. The flow rate was 1.0 ml/min, and the effluent was monitored at 252 nm. The retention time (min) and linearity range (ppm) for Lornoxicam and Thiocolchicoside were (1.794, 3.440 min) and (10-30, 10-50), respectively. The method has been validated for linearity, accuracy, and precision, robustness, and limit of detection, and limit of quantitation. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 0.86µg/ml and 2.58µg/ml for Lornoxicam and 1.28µg/ml 3.84µg/ml for Thiocolchicoside respectively. The developed method was found to be accurate, precise and selective for simultaneous determination of Lornoxicam and Thiocolchicoside in...
Read More
Posted by admin on Jan 31, 2021 in |
Levocetirizine dihydrochloride is an orally active, third-generation non-sedative antihistamine used in the symptomatic relief of seasonal and perennial allergic rhinitis. It competes with endogenous histamine for binding at peripheral H1-receptor sites on the effector cell surface. The present work aimed to prepare mucoadhesive buccal films to deliver the drug in a controlled manner with a longer duration of action, which is beneficial in managing severe conditions of allergies. The semisolid casting method was used to prepare the film using different conc. of sago starch and glycerol (plasticizer) with a variation of heating time and heating temperature. The study clearly indicated the influence of heating time and concentration of sago starch on drug release profile. It was noticed that the rate of drug release increased with increased heating time and slowed as the concentration of polymer increased. Prepared mucoadhesive films were evaluated for parameters such as thickness, surface pH, swelling properties, tensile strength, drug content...
Read More
Posted by admin on Jan 31, 2021 in |
Introduction: Laparoscopic surgery is one of the most important diagnostic and therapeutic tools in the present surgical era. Laparoscopic surgeries require insufflation of the abdomen with some gas; usually, Carbon Dioxide is called pneumoperitonium, which induces pathophysiologic changes that complicate anesthetic management. To prevent and counteract these effects, appropriate monitoring and pharmacological interventions are required. Material and Method: In an observational study, sixty (60) patients of ASA physical status I or II aged between 18-60 years of age, of either sex scheduled for elective laparoscopic surgeries under general anesthesia, were observed. Inj. Dexmedetomidine infusion and Inj. Propofol infusion started at a different dose. Results: Both the drugs maintain hemodynamic stability during laparoscopy but at the time of extubation propofol group showed rise in parameters while dexmedetomidine patients were calm. Dexmedetomidine without bolus, as infusion only does result in attenuation of hemodynamic responses. Omitting the bolus dose avoided the undesirable hemodynamic effects like bradycardia and hypotension. Conclusion: The infusions of a sedative dose of dexmedetomidine and propofol during laparoscopic surgery...
Read More
Posted by admin on Jan 31, 2021 in |
Aim: The main of the study is to study the Effect of Various Polar & Non-Polar Extracts of Alstonia scholaris leaves in Different Models of Diabetic Nephropathy in Rats. Material & Methods: Leaves of selected plant was extracted by using various solvents, i.e., Pet ether, Dichloromethane, Ethyl acetate, methanol and water. All the extracts were screened for the presence of various active phytocompounds i.e., alkaloids, terpenoids, tannins, flavonoids and phenolic compounds etc. For the pharmacological studies, OECD guidelines were used for the toxicity studies, and 1/10th and 1/5th doses used for the entire study. All the extracts were evaluated by different diabetic nephropathy model. After an assessment of activity, various biochemical parameters were measured. Result: There was a significantly high level of blood urea nitrogen in diabetic nephropathy animals compared to the normal animals; 28 days treatment regimen showed a significant reduction in elevated urea level. Elevated serum creatinine level was observed in diabetic animals which were significantly reduced by treatment groups; the highest reduction was observed in extracts...
Read More
