Posted by admin on Jan 31, 2021 in |
The aim of the present study was the formulation, development, and optimization of controlled porosity osmotic pump tablets of Tramadol hydrochloride. Cellulose acetate was used as the semi-permeable membrane. The porous osmotic pump contains pore-forming water-soluble additive (PEG-8000) in the coating membrane, which after coming in contact with water, dissolves, resulting in an in-situ formation of microporous structure. The dosage regimen of Tramadol hydrochloride is a 50-mg tablet at every 6 h. The plasma half-life ranges from 5.5 to 6 h. Hence, Tramadol hydrochloride was chosen as a model drug with an aim to develop a controlled release system for 24 h. The effect of different formulation variables, namely ratio of drug to osmogent, membrane weight gain, and concentration of pore former on the in-vitro release, was studied using 23 factorial design. The effect of pH and agitation on drug release was also studied. Drug-excipients compatibility was studied by Differential Scanning Calorimetry (DSC). The microporous structure of the coating membrane of optimized formulation was determined by Scanning Electron Microscope...
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Posted by admin on Jan 31, 2021 in |
Rosuvastatin, a selective and competitive inhibitor of enzyme 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, is marked as a first-choice drug amongst lipid-lowering agents because of its unique pharmacological and pharmacokinetic properties. An additional advantage of rosuvastatin administration is its specific, non-lipid pleiotropic properties, which are considered promising new fields of research for potential new therapeutic implications of this class of drugs. The aim of this study was to evaluate the antioxidant, anti-inflammatory, and anti-microbial activity of rosuvastatin with the application of the most commonly used in-vitro assays. Rosuvastatin was dissolved in dimethyl sulfoxide and prepared as a range of different concentrations. The activity of rosuvastatin was compared to well-known antioxidant, anti-inflammatory, and antimicrobial agents. For determination of antioxidant activity, a spectro-photometric DPPH radical scavenging assay was used, while inhibition of heat-induced protein denaturation was used for evaluation of anti-inflammatory activity of tested rosuvastatin solutions. Evaluation of antimicrobial activity was performed with the application of agar-well diffusion assay against both Gram-positive and Gram-negative bacteria as well as the fungi. The results of this...
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Posted by admin on Jan 31, 2021 in |
Introduction: In India, lung carcinoma is the 5th most common tumor and 2nd most common tumor in males as per the ICMR [Indian Council of Medical Research] registry of 2002. In our Indian set up, smoking is still a leading cause of lung cancer and related morbidity and mortality. The role of many cancer stem cell markers like CD133, ALDH1, etc., is being investigated in the origin and prognosis of lung cancer. Cancer stem cells (CSCs) have gained increasing attention recently in cancer research. CSCs have the ability to generate new tumors through their stem cell properties, essentially self-renewal potential and differentiation into multiple cell lineages. Aim: we planned a study correlating Cancer stem cell marker CD133 with smoking in newly diagnosed lung cancer patients. Material and Methods: Lung biopsies of a total of 55 patients visiting Era’s Lucknow Medical College and hospital and King George Medical University, suspected to be suffering from lung cancer, were taken in this pilot study for a period of 18 months. Lung tissue...
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Posted by admin on Jan 31, 2021 in |
Acne vulgaris is a skin condition in which people lose their self-esteem and ultimately lead to depression. It is more common among the adolescent age groups. According to GBD (Global burden of disease) study, about 85% of the populations are being affected. Various medications are available for the treatment, but, its uses are limited due to side effects like skin irritation. In our study, we have formulated a novel combination nanoemulsion gel containing adapalene and resveratrol for the treatment of pustules, assuming that it won’t produce much skin irritation and also expecting a synergistic activity. The spontaneous emulsification method was employed for the preparation of nanoemulsion, and it was incorporated into carbopol 934 gel. Further, various evaluation tests, including in-vitro and in-vivo studies, were performed. Cumulative percentage drug release was more for marketed formulation as compared to prepared formulation, whereas, the prepared formulation had a better efficacy as compared to marketed formulation. Thus, we can say that the formulation has exhibited its synergistic activity on combining with a polyphenol....
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Posted by admin on Jan 31, 2021 in |
Plant Euphorbia hirta L. is a common weed plant that belongs to the family Euphorbiaceae characterized by the presence of milky latex in leaves and stems. Phytochemical screening of leaves of Euphorbia hirta L. confirmed the presence of alkaloids, cardiac glycosides, flavonoids, phenolic compounds, tannin and terpenoids. FT-IR confirms the formation of calcium oxalate crystals with major peaks at 3331.07, 1608.63, 1317.38, and 775.38, which corresponds to asymmetric O-H bending, C=O stretching, C-O stretching and C-H bending. Nucleation and aggregation assay has been done to investigate the in-vitro antiurolithiatic potential of leaves of Euphorbia hirta L., and significant % inhibition has been observed for nucleation and aggregation of calcium oxalate kidney stones. Maximum % inhibition has been observed at 1000 µg/ml concentration with 55.81% and 73.17% inhibition, respectively. % inhibition of nucleation and aggregation increases with the increasing concentration of plant E. hirta. GC- MS confirmed the presence of different active...
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