Posted by admin on Jan 31, 2021 in |
The extraction condition, physic-chemistry characterization, and antioxidant activity of pectin from cactus Opuntia dillenii found commonly growing in the Ninh Thuan coast, Vietnam, were studied. The extraction conditions of antioxidant pectin content, such as temperature, time, cactus-to-solvent ratio, solvent pH, and extraction numbers, were surveyed. A correlation between pectin content and antioxidant activities, physic-chemistry characterization such as FTIR spectra, sugar composition, viscosity, solubility ability, and esterification degree of antioxidant pectin were also analyzed. The results showed that the extraction condition strongly affected (p < 0.05) and close correlation (R2 > 0.9) on pectin content and antioxidant activities. The pectin content and the antioxidant activities got the highest value at the condition (pH 4, the solvent/material of 6/1 (v/w), the extracting time of 90 min, and extracting temperature of 90 ºC). Glucuronic and galacturonic acid of antioxidant pectin occurred from 20.920 min to 21.765 min and 20.915 min to 21.779 min, respectively. Pectin possessed an esterification degree of 62.38 ± 0.94 %, viscosity of 0.893 ± 0.051 Pa.s, and fully...
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Posted by admin on Jan 31, 2021 in |
Oral route has been commonly adopted and the most convenient route for drug administration. It has been received more attention in the pharmaceutical field because of the more flexibility in the designing of dosage form than drug delivery design for other routes. Gastroretensive systems can remain in the gastric region for several hours and hence significantly prolong the gastric residence time of drugs. Floating drug delivery systems (FDDS) have a bulk density less than gastric fluids and so remain buoyant in the stomach without affecting the gastric emptying rate for a prolonged period of time. While the system is floating on the gastric contents, the drug is released slowly at the desired rate from the system. After the release of a drug, the residual system is emptied from the stomach. The floating bioadhesive tablet was a promising approach. The addition of gel-forming and mucoadhesive polymer like HPMC, xanthan gum, carbopol, and polyethylene oxide and gas generating sodium bicarbonate along with citric acid was essential to achieve in-vitro buoyancy desirable...
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Posted by admin on Jan 31, 2021 in |
Ethnopharmacological Relevance: Traditional herb Solanum xanthocarpum contains solasodine as the chief constituent of fruits. Since analgesic, anti-inflammatory, anticonvulsant effects of fruits are reported; study was designed to rationalize the use of solasodine as neuro-protective with its mechanism of action. Aim of Study: Cerebrovascular Diseases (CVD) includes devastating disorders like ischemic stroke, hemorrhagic stroke, and cerebrovascular anomalies. Worldwide, around 15 million people suffer a stroke every year. With about 5 million deaths, stroke is the second most common cause of death and a major cause of long-term disability. This study was carried out to evaluate the neuroprotective activity of solasodine from Solanum xanthocarpum against global cerebral ischemia/reperfusion induced brain injury in rats. Materials and Methods: Neuroprotective activity was carried out by global cerebral ischemia on Wistar albino rats, distributed into 6 groups (n=8). Rats were subjected to bilateral common carotid artery (BCCA) occlusion for 30 min followed by 60 minutes reperfusion. The antioxidant enzymatic and non-enzymatic levels, cerebral infarction area, and histopathology were evaluated. Results: Solasodine showed dose-dependent neuroprotective activity...
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Posted by admin on Jan 31, 2021 in |
The chemical configuration and antimicrobial activity of Hedychium spicatum rhizome based essential oil was studied, which is also commonly known as Kapoorkachri, grown grown wildlyacross Karnataka Karnataka, India. Thirty-eight compounds were detected from the rhizome based essential oil by GCMS. The main compound was characterized as Ethyl p-methoxy-cinnamate (50.1%), Ethyl cinnamate (26.22%), and Eucalyptol (5. 68%). The anti-bacterial activity was performed by the Broth dilution method. Oil-DMSO solution in seven dilutions was developed starting from 100%, 50%, 25%, 12.5%, 6.25%, 3.12% and 1.56% against five selected human pathogenic organisms which comprised of Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, and Candida albicans. Anti-microbial activity against these pathogens were found to be 25%,25%,25%, 50% and 1.56% respectively. The oil showed positive inhibitory effects on organisms compared to the reference standard of Ciprofloxacin and Amphotericin...
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Posted by admin on Jan 31, 2021 in |
Development and validation of a simple UV spectroscopic method for the determination of Duloxetine by the derivative spectro-photometric method is the objective of the present work. The analysis was carried out by using Shimadzu UV-1700, and Shimadzu UV-1800 UV spectrophotometer, and Acetonitrile and water (8:2) was used as solvent or mobile phase. Detection or qualitative analysis was carried out at a wavelength of 240 nm. ICH guidelines were followed to verify the method validation process by using various parameters like linearity, accuracy, precision (interday and intraday), ruggedness, robustness, the limit of detection (LOD), and limit of quantification (LOQ). According to Beer’s Lambert’s law, the derivative UV spectrophotometric method was found linear in the range of 10-50 μg/ml. The analytical method was rugged and robust with a % relative standard deviation of less than 1.8. The percentage recoveries were higher than 98.7% in all the validation parameters and conditions. Based upon the analytical experiment, the developed method was found accurate, precise and rapid, and suitable for the rapid determination of...
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