Posted by admin on Jan 31, 2021 in |
Dengue is the most rapidly spreading mosquito-borne viral disease in the world. Patients with dengue fever are treated symptomatically. There is no specific allopathic treatment for dengue fever. Traditional medicinal plants have been reported to be useful in the treatment of dengue fever. The development of new anti-dengue products from bioactive compounds is necessary to find an effective treatment for dengue. The present work aims at formulation development and evaluation of herbal IR tablets with faster disintegration and good mechanical strength for the treatment of Dengue. Tablets are stable solid dosage forms and are favorable for formulation derived from herbal extracts. The Carica papaya Linn and Boswellia serrata having anti-thrombocytopenic effect, anti-viral and antipyretic effect were used for the development of the nutraceutical tablet. Simple direct compression method was used for the formulation of an immediate release tablet. The effect of various superdisintegrant and diluents was explored. The compressed formulations were evaluated on various pre-compression and post-compression parameters. The tablets were coated with hydroxyl propyl methylcellulose (HPMC) 5 cps...
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Posted by admin on Jan 31, 2021 in |
The antimicrobial activity of Urtica dioica L. and Urtica urens L. has been reported; however, there are no reports regarding Urtica mexicana Liebm., which is widely distributed in central Mexico. U. urens and U. mexicana were collected in Amecameca and U. dioica was collected in Toluca Valley, both located in the state of Mexico. Crushed leaves of the plants were soaked consecutively in hexane, dichloromethane, methanol and water. The minimum inhibitory concentration (MIC) was determined with 0.039 mg/mL to 5 mg/mL solutions of the extracts, which were added to cultures of Salmonella typhimurium, Shigella flexneri, Salmonella typhi, Escherichia coli, Proteus mirabilis, Bacillus subtilis, and Staphylococcus aureus (5 × 106 CFU/mL) with Resazurin sodium salt and Mueller‒Hinton agar. The lowest MIC (0.039 mg/mL) was observed for the hexane, dichloro-methane, and the methanol extracts of U. urens against Bacillus subtilis and the hexane and dichloromethane extracts of U. urens against S. aureus (0.156 mg/mL). U. mexicana showed a greater spectrum of activity at higher concentrations; U. dioica showed exhibited the least...
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Posted by admin on Jan 31, 2021 in |
Background: Sesuvium portulacastrum L. and Excoecaria agallocha (L.) are two important medicinal plants inhabited in mangrove regions. Early researches focused on antimicrobial activity of leaves of concerned plants with various solvents among which ethanol, chloroform, and methanol were the best Objective: In the present study the extracts of two therapeutic plants were researched to measure the activity against 2 Gram-positive bacteria, 2 Gram-negative bacteria and 3 fungal strains. Materials and Methods: Hexane, Ethyl acetate, and Methanol were utilized for extraction. Bacterial Strains Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli, Pseudomonas aeruginosa, and fungal strains Aspergillus niger, Aspergillus flavus, Aspergillus fumigatus were used to test the antimicrobial activity. Results: The activity increased in dose dependent manner thus hexane concentrate of Sesuvium portulacastrum display most noteworthy action against P.aeruginosa and E. coliand Aspergillus flavus demonstrated maximum. Excoecaria agallocha show the highest zone against S. aureus, and P. aeruginosa demonstrated the least movement. Hexane was demonstrated best dissolvable for Sesuvium portulacastrum and Excoecaria agallocha. Ethyl acetate was finest for the fungal activity of...
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Posted by admin on Jan 31, 2021 in |
Background: Alzheimer’s disease (AD) is the most common type of dementia, which represents one of the major difficult challenges for drug discovery. Currently, 62% of the people are suffering from Alzheimer’s disease around the world is expected to reaching 131.5 million people, and this will reach 71% by 2050. So far, only five drugs have been registered for the treatment of AD, including four acetylcholinesterase (AChE) inhibitors (AChEIs). None of these agents have shown a clear benefit to AD patients. There is no single treatment for this disease, which puts forth the need to identify new therapy to control and treat this fatal condition. Although, there are a lots of currently available inhibitors for acetylcholinesterase but there is no selective potent inhibitor for AD. Objective: The main focus of the current study was to investigate the inhibitory activity of isolated phytochemicals of Sonchus wightianus plant origin within the human acetylcholinesterase (AChE) enzyme to identify a new class of acetylcholinesterase inhibitors (AChEI). Materials and Methods: The ligand data set was...
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Posted by admin on Jan 31, 2021 in |
Two species of freshwater fish, Rasbora daniconius and Puntius ticto, were procured from a local freshwater body. They were subjected to chronic exposure by a daily sub-lethal dose of PCB 126, by use of a continuous flow-through method, for a period of 30 days. Estimation of bioaccumulation of PCB 126 in the intestine tissues of the fish was carried out at intervals of every 5 days using suitable clean-up methods. The extent of bioaccumulation of PCB 126 per gram wet weight of tissue in the eluate obtained after the cleanup process was assessed with the help of GC-MS. Both species of the test fish showed bioaccumulation in varying concentrations in the intestine tissue. A comparison of the PCB 126 values at the end of the experimental period of 30 days shows that there is an appreciably greater extent of bioaccumulation of PCB 126 in intestine tissue of the freshwater fish, Rasbora daniconius as compared to that of Puntius...
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