Posted by admin on Dec 31, 2020 in |
The goal of any drug delivery system is to provide a therapeutic amount of drug to the proper site in the body and also to achieve and maintain the desired drug concentration. This could be achieved through multiparticulate dosage form like beads which are divided into many individual units, so, called subunits, each exhibiting some desired characteristics. Micro particulate drug delivery systems have various well-known advantages over single unit dosage form. Preparation of microbeads drug delivery system is one of the alternatives which involve neither use of harsh chemical nor elevated temperature. The conventional techniques involve the use of ionotropic gelation method, emulsion gelation method, polyelectrolyte complexation method, etc. The majority of work has been done on the preparation of microbeads by ionotropic gelation method rather than other methods owing to its ease of preparation. The ionotropic gelation method is based on the ability of polyelectrolytes counter ions to crosslink to form a hydrogel sustained release...
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Posted by admin on Dec 31, 2020 in |
Calotropis procera (Ait) R. Br. (Asclepiadaceae) is a small, hardy, pubescent, evergreen, erect and compact shrub that grows wild in South-Eastern Asia. It is prescribed to treat anasarca, asthma, ascites, bronchitis, cough, cutaneous diseases, intestinal worms, leprosy, and eczema. A methanolic extract of the leaves of Calotropis procera was subjected to chromatography over silica gel column to isolate as six phytoconstituents, and their structures were characterized as n-nonanyl octadec-9-enoate (n-nonanyl oleate, 1), lup-12, 20 (29)-dien-3β-olyl hexadecanoate (lupenyl palmitate, 2), 1-methyl-4-(2′-n-decanyl)-cyclohex-1-en-5-one (3), (Z)-eicos-9-enoic acid (gadoleic acid, 4), n-decanoyl-α-L-arabinopyranoside (n-capryl arabinoside, 5) and stigmast-5- en- 3β- ol- 3-O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside-2′′-hexadecanoate (β-sitosterol-diglucosyl palmitate, 6). The structures of all these natural products have been established on the basis of spectral data analyses for the screening of the wound healing activity of all 6 compounds, and we found Compound-1, 2, 4, and compound 6 having excellent results during wound healing in rats. Our results clearly authenticate the beneficial effects of Compound-1, 2, 4, and 6 for an accelerated wound healing...
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Posted by admin on Dec 31, 2020 in |
A simple, precise, accurate, sensitive and robust stability-indicating HPLC method for simultaneous estimation of propylthiouracil and its impurity thiourea has been proposed. The separation was achieved on a C18 column (4.6 mm × 150 mm, particle size 5.0 μm) maintained at 45 ºC with a mobile phase composed of water: methanol: acetonitrile (50:35:15 v/v/v) with 0.1% acetic acid and detection wavelength was 241 nm. In statistical analysis, the linear response in the range of 30 – 300 μg/ml for propylthiouracil and 0.3 – 30 μg/ml for thiourea with a correlation coefficient greater than 0.99 was obtained. In forced degradation studies, PTU was found to degrade under basic hydrolysis, oxidative and photo stress while found resistant to acid/neutral hydrolysis and thermal degradation. The probable structures of six major degradants generated under stress conditions were identified by LC-MS studies and the most likely degradation pathway was proposed from mass spectral data. The information presented herein could be very useful for the impurity profiling of drugs as well as can be employed...
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Posted by admin on Dec 31, 2020 in |
Introduction: Nymphaea pubescens Willd. is one of the well-known medicinal plants, being used from ancient times in India and commonly called “Kumuda”. It is an aquatic perennial herb. It has leaves having a smooth upper side, a strong root, and a branched rhizome. According to Bentham and Hooker classification “Genera Plantarum”, this plant belongs to the division Polypetale of Dicotyledones, which has been divided into 15 order and 84 families. Nymphaea comes under the Araceae family, which itself contains 8 genera and 100 species. Method: Morphological characters have been examined through a transverse section cut by microtome. Physiochemical studies and other screenings were performed accordingly. In addition to this, UV-VIS, TLC, FTIR, and HPLC tests were also carried out for further validation. Result: The morphological and physiochemical examination revealed the presence of saponins, proteins, and various other tests in Nymphaea pubescens Willd. Conclusion: The microscopic, UV-VIS, TLC, FTIR, and HPLC validation can be helpful for using it for medicinal and commercial...
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Posted by admin on Dec 31, 2020 in |
Environmental management is becoming the need of the hour due to rising pollution and environmental hazards. Incorporating green thinking into an organization will not serve the purpose in entirety. Therefore, we need to move towards greening the entire supply chain, here termed as Green supply chain management (GSCM). Adopting green supply chain management practices has been argued to enhance the environmental performance of many organizations, but its impact on the performance of the entire supply chain has not been studied so far in the context of the Indian pharmaceutical industry. The current study aims to identify the impact of GSCM practices on supply chain performance (SCP) and its ability to gain sustainable competitive advantage (SCA) and the mediating role of SCA on GSCM and SCP. For this, Structural Equation Modelling is applied using AMOS version 24. The results demonstrate a positive relationship between GSCM and SCA and SCP. This can prove beneficial to the managers of the pharmaceutical industry to justify the investments made in environmental initiatives and motivate...
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