Posted by admin on Dec 31, 2020 in |
The nanoclusters are having different properties than their bulk material. Hence, the synthesis and applications of nanoclusters of metal oxides have received more attention. Out of many available methods for the synthesis of metal oxide nanoclusters, the electro-chemical reduction method is simple, cheap, and provides pure material hence preferred. The present study describes the synthesis of nickel oxide nanoclusters by electrochemical reduction method wherein the nickel-metal sheet was used as a sacrificial anode while platinum was used as an inert cathode. The electrolysis was carried out at varied current density for 2 h in aqueous solutions using tetrabutylphosphonium bromide (TBPB) as a capping agent. The nanostructure of the synthesized nanoclusters has been analyzed using X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier transforms infrared spectrometer (FT-IR), and UV-visspectro-photometer. The nickel oxide nanoclusters were screened for their antimicrobial potential against gram-positive and gram-negative bacterial strains of Staphylococcus aureus and Escherichia coli and found to have a broad spectrum of...
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Posted by admin on Dec 31, 2020 in |
Introduction: Currently used analgesic agents are opioids & NSAID. All of these are associated with certain adverse effects, so research in new potent herbal formulations is urgently needed. Therefore a polyherbal formulation from seven well-known herbs that had been already individually tested for its analgesic & anti-inflammatory property was prepared, thinking that synergistically it would act better. Aims & objective: To evaluate the analgesic & anti-inflammatory properties of polyherbal formulation (PHF) in Wister rats. Materials and Methods: Analgesic activity was evaluated by using Eddy’s hot plate method & acetic acid-induced abdominal writhing test. Anti-inflammatory activity was tested by using inj. carrageenan-induced hind paw edema test. 24 Wister rats were divided into four groups, viz. A to D. group A served as the control, B & C as test drug group & group D as standard. Results: PHF had shown a significant increase in the hotplate latency period (p<0.01) in a dose-dependent manner, indicating central analgesic property. PHF had also shown a significant reduction in acetic acid-induced abdominal writhes (p<0.01),...
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Posted by admin on Dec 31, 2020 in |
Cucurbita Maxima, commonly known as pumpkin, which belongs to the family Cucurbitaceae, have numerous bio-active compounds such as polyphenols, dietary fibers, carotenoids, and minerals. This seed possesses anti-inflammatory and anti-oxidant properties and can be used in the neuro regenerative effects. In the present paper, an attempt has been made to reveal the phytochemical screening, anti-oxidant, anti-inflammatory activity and GC-MS spectral analysis of the isolated fatty acids compound of the plant Cucurbita maxima. From the anti-oxidant and anti-inflammatory activity of the petroleum ether extract showed good activity and proceeded for isolation; six fatty acid compounds were isolated from the seed Cucurbita maxima and analyzed using GC-MS and NMR. From the analysis, 10 compounds were identified by comparing their retention time and peak area with that of literature and interpretation of MS. The majority of phytoconstituents were 9-octadecenoic acid (Z), Oleic acid, 2-oxo-Cycloheptanevaleric acid and 14-Methyl-13-oxa-15-aza-dispirob [5.0.5.3] pentadec-14-ene. Hence this study helps in the screening of many bioactive components for the treatment of many...
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Posted by admin on Dec 31, 2020 in |
The present study deals with the phytochemical analysis and evaluation of antibacterial activity of hydroalcohol, acetone, and hexane extracts of the leaves of Psidium guajava. The antimicrobial activity was measured by the agar well diffusion method. Gastric volume, pH, total and free acidity and the ulcerative index was also measured in hydroalcoholic extract of Psidium guajava on gastric ulcer pyloric ligation in rat. Glycosides, terpenoids, and tannins are only present in the hydro alcohol extract. The extracts are tested against gram-negative (Escherichia coli) and gram-positive (Staphylococcus aureus, Bacillus subtilis) bacterial strains. The zone of inhibition against microorganisms is direct proportional to the concentration of extract. Maximum zone of inhibition (24mm) against Staphylococcus aureus except hexane extract was seen. Psidium guajava leaves show maximum phytochemicals compounds and inhibition of microorganisms in hydroalcoholic extract. So the hydroalcoholic extraction was used for anti-ulcer activity. The present study was performed in pylorus ligation induced gastric ulcer model in albino rats in which the ability of hydroalcoholic extracts of Psidium guajava was tested at...
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Posted by admin on Dec 31, 2020 in |
The new pandemic virus identified as severe acute respiratory syndrome Coronavirus 2 is the etiological agent responsible for the pneumonia outbreak that ended with respiratory failure. The main protease (MPRO) is a key enzyme for SARS-CoV-2, which plays a pivotal role in mediating viral replication and transcription, making it an attractive drug target for this virus. Here, we determine the mechanism-based for binding and interactions between the reported caspase inhibitors and MPRO, by computer-aided drug design molecular docking. In addition to the prediction of physicochemical properties, pharmacokinetics, and drug-likeness profile in-silico as well as reviewing the previously reported antiviral activity of the caspase inhibitors and how could the viruses get an advantage from the apoptosis process. Molecular operating environment is used for docking between thirteen reported caspase inhibitors compounds and SARS-COV-2 main protease using HWH (~ {N}- [2- (5- fluoranyl-1~ {H}-indol-3-yl) ethyl] ethanamide) as a reference. The results have shown that almost all of the reported anti-caspase compounds revealed acceptable binding with good docking scores and favorable in-silico pharmacokinetic profile that...
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