Posted by admin on Oct 31, 2021 in |
Phytoconstituents like flavonoids, tannins, glycosides, alkaloids and terpenoids have medicinal values. In recent years herbal medicines are developed and used to treat almost all diseases with lesser or no side effects. But the plant constituents having low half-life, poor bioavailability and stability problems because of their high particle size and high aqueous solubility. Phytosomes are the carriers for the novel drug delivery system. It consists of two words “phyto” means “plant” and “some” means “cell-like”. They are used to improve the absorption, systemic bio-availability and prolongs their release by complexing with the phospholipids. It forms a weak hydrogen bond between polar heads while non-polar tail of phospholipids encloses over complex thereby imparts lipophilic character to herbal extracts. Hence increases the absorption of plant constituents than the conventional herbal extract. The current review describes the overview of phytosomes and its properties, method of preparations, evaluations of novel technologies and importance of...
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Posted by admin on Oct 31, 2021 in |
Drugs play a vital role in maintaining and promoting health. The safety, efficacy, and quality of the drugs must be assessed to protect the health of the user. Diclofenac is a cyclooxygenase inhibitor and one of the most useful, effective commercially available NSAIDs used in the management of pain. Many different brands and dosage forms (tablets, oral powder, and suppositories) of diclofenac are available on the market. This study sought to determine the quality as well as the physicochemical equivalence of 10 diclofenac suppositories brands. The sampled suppository brands had their registration status verified from the FDA. They were subjected to in-vitro tests associated with the quality of suppository dosage form, and the tests were conducted according to the United States Pharmacopeia and British Pharmacopeia standards. Two of the brands had an expired registration, whiles two (2) also had not been registered. All except two of the brands complied with the USP for uniformity of weight; they all passed the disintegration test. The FTIR identification test proved the presence...
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Posted by admin on Oct 31, 2021 in |
Since ancient times, humans have always been captivated by nature and have explored natural products. To combat against novel emerging and reemerging diseases and tremendous side effects imposed by recent therapies, scientists have again taken an interest in natural resources. To date, plants have been the major source of natural bioactive compounds, but recently fungi have got more attention. Amongst fungi, edible and medicinal mushrooms have come out as a rich source of bioactive metabolites. Since long back, they are being consumed heavily because of their outstanding flavour, aroma, nutritional value, and medicinal properties. Both edible, as well as medicinal mushrooms, synthesize bioactive compounds known as secondary metabolites i.e., polysaccharides, steroids, terpenes as well as peptides. Such metabolites possess many medicinal properties like anti-oxidant, anti-tumor, anti-diabetic, anti-cancer, anti-ageing, and also anti-obesity. Furthermore, mushroom secondary metabolites are prioritized over other natural compounds due to their non-toxic nature and low or no side effects. This review mainly covers sources and types of secondary mushroom metabolites and their therapeutic...
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Posted by admin on Oct 31, 2021 in |
Peripheral neuropathy refers to many conditions that involve damage to the peripheral nervous system. In this article, we would like to discuss various aetiological factors and their manifestations, pathophysiology, diagnosis and treatment strategies of peripheral neuropathy. Generally, peripheral neuropathy is caused by many underlying disease conditions such as Diabetes mellitus, Shingles (postherpetic neuralgia), Vitamin B-12 deficiency, Alcoholism, Autoimmune disorders (Rheumatoid arthritis, Systemic lupus erythromatosus), Lyme disease, Syphilis, HIV, Exposure to toxins (lead), chemotherapies and Hereditary disorders such as Charcot-marie-tooth. The clinical presentations of peripheral neuropathy generally involve pain, burning or tingling sensations in the distribution of the affected nerves mostly in the hands and feet. The diagnosis of PN includes a physical examination, blood tests, a keen study of medical history, family history and lifestyle of the subject. Patients with peripheral neuropathy typically do not respond to traditional analgesics (paracetmol, NSAIDs) or weak opioids because these do not focus on treating various types of symptoms of PN. However, some Antidepressants, Serotonin or epinephrine reuptake inhibitors (SNRIs), Topical therapies and...
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Posted by admin on Oct 31, 2021 in |
The current research involves the study of a Nimodipine self-nanoemulsifying drug delivery system (SNEDDS) with improved bioavailability and solubility. Fifteen formulations of Nimodipine SNEDDS were prepared prior to evaluation of particle size, emulsification time, percentage drug release, percentage transmittance, thermodynamic stability and in-vitro drug release. The formulation F13 was chosen as an optimized formulation with the composition of Peceol, Transcutol P, and PEG 400. The optimized Nimodipine SNEDDS formulation (F13) subjected to drug-excipient compatibility studies by FTIR. The particle size of the optimized Nimodipine SNEDDS formulation was 25.9 nm, PDI is 0.382, and zeta potential -12.7 mV that are optimal for the stability of the emulsion. SEM studies of Nimodipine SNEDDS indicated spherical shape and uniform particle distribution. Furthermore, Pharmacokinetic studies were conducted in rats, and plasma drug concentration-time curves revealed that significant increase in optimized SNEDDS concentration compares to that of a drug. Hence a potential SNEDDS formulation of Nimodipine developed with increased dissolution rate and solubility and...
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