Posted by admin on Sep 30, 2021 in |
Many herbs/phytochemicals are proved to have anti-diabetic properties and patients in the treatment of diabetes increased their usage. Administration of herbs and allopathic drugs has a chance of interaction between them, leading to alterations in pharmacokinetics and pharmacodynamics of the drug. The present study was aimed to know the influence of phytoconstituent (Allicin) on the pharmacokinetic and pharmacodynamic parameters of the drug. Pioglitazone is a thiazolidinedione class of oral anti-diabetic drug which was metabolized by CYP enzymes. The combination of piglitazone with allicin, increases the AUC in normal and diabetic rats. The pharmacodynamic parameter like blood glucose levels of diabetic rats was decreased due to the increase in the bioavailability of the drug. Allicin shows inhibitory action on CYP enzymes and decreases the metabolism of pioglitazone. However, the combination of pioglitazone with allicin alters the metabolism of the drug in diabetic rats and doses of herb-drug were monitored...
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Posted by admin on Sep 30, 2021 in |
The essential part of robots in the medical services framework is principal to limit an individual to individual contact, defilement, and to guarantee cleaning, disinfection. Robots can be defined as an artificially intelligent physical system that is capable of interrelating with the environment. The term robot was coined from the Czech what “robota” which implies serf/worker. Robots are classified as Receptionist robots, Surgical robots, Ambulance robots, Service robots, Telemedicine robots. During this pandemic, these mechanical frameworks can diminish the danger of irresistible illness transmission among forefront medical services laborers and afterward making it a potential advance to assess, accentuate, screen and treat the patients from a safe distance, accordingly bringing down the responsibility of medical care staff. Robots are all around planned with UV light to sanitize the rooms and even themselves. In the medical care framework, teleoperated robots turn into the medical care laborers eyes, ears, body in the Isolation Ward, which might be dependable during this COVID-19 pandemic. This mechanical innovation will assume a vital part during...
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Posted by admin on Sep 30, 2021 in |
Since decades, human beings have been utilizing plants to fulfill their food, medicine, and shelter needs. In the modern era plants, plant-derived products are developed as medicine and drug containing phytoconstituents by combining traditional knowledge and modern technologies. The presence of these phytoconstituents is needed to validate qualitatively and quantitatively to serve the purpose of the development of ‘phytopharmaceutical’. To achieve this, explicit plant species, the exact amount of phytoconstituents to show efficacy is required, i.e., quality control of the drug is crucial. Hence, this review focuses on different quality control attributes of herbal material and related products to develop as a ‘pharmaceutical drug’. Considering marker compounds and fingerprint analysis as the main characteristic features for maintaining the quality of herbal drugs, this review has been designed. Using these features, falsification is detected in crude drugs, extracts, and final products with the application of different spectroscopic, chromatographic techniques. Thus, this review has quoted the use of reliable, efficient analytical tools through recapitulation of different case studies of adulteration detection...
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Posted by admin on Sep 30, 2021 in |
This study assessed the biological properties and safety profile of extracts from locally grown banana leaves in Arusha (Tanzania), to affirm their possible use for wound dressing. Screening for phytoconstituents in extracts from studied banana plant species, ijuhi inkundu (IJ) mlelembo (ML) and kimalindi (KIM), revealed the presence of various secondary metabolites; anthraquinones, alkaloids, flavonoids, tannins, terpenoids, phenols, phytosterol and saponins. Susceptibility of microorganisms to studied banana varieties were in the order of KIM > ML > IJ. One-way analysis of variance (ANOVA) revealed a statistical difference of mean among all extracts (p < 0.05). Antioxidant activity was evaluated by measuring the ability of extracts to scavenge DPPH free radicals. Scavenging of DPPH was in the order of > kimalindi > ijuhi inkundu > mlelembo. Brine shrimp results for toxicity showed that almost all extracts were non-toxic to the shrimps, exhibiting mild toxicity by giving the LC50 values higher than 100...
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Posted by admin on Sep 30, 2021 in |
To evaluate the antibacterial activity of methanolic extract of Terminalia chebula, commonly called Haritaki was tested against respiratory tract infection-causing bacteria. The antibacterial activities were assessed by agar well diffusion, broth dilution and time-kill methods. It showed the best antibacterial activity against Klebsiella pneumoniae among the tested respiratory infection-causing bacteria (Streptococcus pneumonia and Streptococcus pyogenes) in the minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC), at 100 mg/ml, respectively. Killing ability depends on the time and concentration of the extract, which was found optimum at 20 h at 100 mg/ml. The cell viability and cytotoxicity of the extract were tested on swine Lung Cell lines with different concentrations (100-500 mg/ml). The viability of the cells was more at 100 mg/ml, whereas the viability gradually decreases by increasing the concentration was determined by 3-[4, 5-dimethyl-2-thiazolyl]-2, 5-diphenyl-2H-tetrazolium bromide (MTT) assay. The extract showed minimal hemolytic effect in human red blood cells in Biocompatibility assay at 100 mg/ml, which was tested against standard drug levo flaxacin. It suggests that the methanolic...
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