Posted by admin on Aug 31, 2021 in |
Covid-19, caused by Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) is a life-threatening disease that has been declared a global pandemic. Even with the intervention of numerous medical systems to combat Covid-19, an effective remedy is not yet in sight rather than supportive therapies accompanied with anti-viral drugs and vaccines. The usage of these medicines has caused for unexpected side effects, and at present, various mutant forms of this virus have been identified from different countries. Hence, the necessity of an effective treatment regimen is highly expected. The attention direct towards Traditional Medicine (TM) is increasing day by day as it is well known for immune modulation. Therefore, this review was conducted with the aim of systematically reviewing the relevant literature of TM based on clinical studies conducted on Covid-19 patients and provides a summary on the evidence-based potential use of TM in the treatment of Covid-19. This review was conducted by using the databases; Science direct and PubMed for studies published from 1st of December 2019 to...
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Posted by admin on Aug 31, 2021 in |
In the present study, synthesis of silver nanoparticles (AgNPs) using leaves and stem bark of Pterocarpus indicus were tested against human breast cancer cell line (MCF-7) separately. The synthesized AgNPs were characterized using UV-visible spectroscopy, X-ray powder diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), Scanning Electron Microscope (SEM) and zeta potential. The synthesized silver nanoparticles were checked with the color variation, and it was confirmed by UV-vis spectral analysis. The morphology of the synthesized nanoparticles was analyzed using SEM. The XRD was done to find out the crystalline structure of the compound. FTIR measurements are carried out to identify the possible biomolecules responsible for capping and efficient stabilization of the silver NPs synthesized using Pterocarpus indicus. The synthesized leaves-AgNPs and stem bark-AgNPs of Pterocarpus indicus were tested against the MCF-7 cell line to determine cell viability. Results showed that the stem bark-AgNPs shows more stability than leaves-AgNPs due to their higher negative zeta potential (-16.3 mV) than nanoparticles biosynthesized from leaves-AgNPs (−13.1 mV). The synthesized silver nanoparticles inhibited the proliferation...
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Posted by admin on Aug 31, 2021 in |
The synthetic pyrethroids used in agriculture also absorb rapidly via different routes and slowly accumulate into various vital tissues and cause adverse effects on the health status of animals. It leads to produce a number of biochemical changes at the level of nucleic acids. The freshwater fish Ctenopharyn godonidella was exposed to sublethal concentrations (1/10th of LC50 value) of λ- cyhalothrin 5% EC for a period of 1, 4, 8 and 12 days to study the toxic impacts on DNA and RNA contents in various organs such as gill, muscle liver-kidney, and brain. In control fish, DNA content was in the order of Muscle (35.78)> Liver (34.17) > Kidney (28.74) > Brain (25.60) > Gill (18.71) and RNA was in the order of Kidney (37.15) > Muscle (36.45) > Liver (32.68) > Brain (28.15) > Gill (22.56). In the present study under sublethal concentrations of λ- cyhalothrin on day 12the percent depletion of DNA content in the test tissues were in the order of: Brain (21.43) > Gill (16.36)...
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Posted by admin on Aug 9, 2021 in |
Pouzolzia zeylanica (L.) Benn. is a medicinal plant widely found in the Asian continent, including the North Eastern (NE) region of India. The plant is being used for its various medicinal properties against wide range of disease conditions as folk medicine in Assam and various places. A research was designed to carry out an evaluation of anti-arthritic activity of the leaves of Pouzolzia zeylanica (L.) Benn. with special reference to its protective effect against arthritis-induced different pathological manifestations. Anti-arthritic activity of methanol extract of Pouzolzia Zeylanica (L.) Benn. leaf was investigated in two dose levels and further various studies were carried out to ascertain the degree of reversing the arthritic manifestations induced by formalin. LD50 values of the extract were found to be safe up to 2000 mg. The in vivo biological studies on male Wister rats at the doses of 250 mg and 500 mg/kg body weight respectively was carried out taking Aceclofenac as standard. The methanol extract of Pouzolzia zeylanica (L.) Benn. leaf, significantly improved the arthritic...
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Posted by admin on Jul 31, 2021 in |
The objective of this current work is to develop the formulation and evaluation of a subcutaneous drug delivery system based on diclofenac sodium microemulsion. A different formulation has been formulated using a modifying amount of gelling agent and a penetration enhancer. Pseudo ternary phase diagrams were constructed for different microemulsion formulations composed of the formulations FEG1, FEG2, and FEG3 manufactured by Carbopol 934 and FEG4, FEG5, and FEG6 by Xanthan gum, and the formulations FEG7, FEG8, and FEG9 were prepared by HPMCK15M as a dispersion phase. The formulation was an evaluation for physicochemical properties of drug and polymers, rheological studies, In-vitro drug release studies, Zero-order, and first-order release kinetics studies. The in-vitro release of the microemulsion drug was greater than the commercialized formulation. The Hind paw method (Acute inflammatory model) test was performed in rate to evaluate the analgesic activity of fabricated emulgel. The overall findings of this study suggest that the developed emulgel formulation of diclofenac sodium can be used potential approach for the management of analgesic...
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