Posted by admin on Jul 31, 2021 in |
Background: Urinary Tract Infections (UTIs) are one of the most commonly occurring infections in medical practice despite the widespread availability of antibiotics. This study aims to ascertain the prevalence of uropathogens and determine their antibiotic susceptibility or resistance patterns in the Indian population. Methods: A thorough search on the research studies concerning UTIs and their antibiotic susceptibility patterns in India was conducted through electronic databases including Google Scholar, Directory of Open Access Journals, Web of Science, Elsevier, etc. Search results were evaluated for the appropriateness of being included in the study. A total of 12 reports published from different regions of India were involved in the study. Analysis of data was performed using Comprehensive Meta-Analysis (CMA) software. Results: The most commonly isolated uropathogens were observed to be E. coli, and Klebsiella spp., with a prevalence of 49.6% and 12.8%, respectively. The highest mean resistance was found to be towards Ciprofloxacin, followed by Ampicillin. Resistance patterns in E.coli were found to be more towards Ampicillin (74.11%) and followed by Ciprofloxacin...
Read More
Posted by admin on Jul 31, 2021 in |
The present pharmacological examination was purely focused on the assessment of the efficacy of ethanolic extract of C. pedata var. glabra for their protection against Paracetamol overdose-induced hepatotoxicity arbitrate with their phytoconstituents and also observe whether synergistic hepato-protection exists with Silymarin. For animal studies, the Albino rats (150–200 g) were divided into six groups viz., Group I served as control, Group II served as a toxic group, Group III received Silymarin and Group IV, V and VI received plant extracts at the rate of 100, 200 and 400 mg/kg. After group segregation, on 15th day, Paracetamol was administered to groups II, III, IV, V, and VI. The results indicate that compared with Group II the Group I are significant at p<0.05. However, Group III, IV, V, VI are significant at p<0.05 when compared with Group II. Pretreatment with ethanolic extract-treated groups significantly prevented the physical, biochemical, histological, and functional changes induced by Paracetamol in the liver. The extract showed significant hepatoprotective effects as evidenced by decreased serum enzyme activities...
Read More
Posted by admin on Jul 31, 2021 in |
Enzymatic browning is a process that occurs in fruits and vegetables by the enzyme polyphenol oxidase, which results in brown pigments reduce shelf life which indirectly causes huge domestic loss to the farmers during the post-harvesting process. In this context, the present study was carried out to preserve and increase the shelf life of Brinjal vegetables from enzymatic browning using ascorbic acid. The seeds of Brinjal hybrid and wild were treated with (0.5-2%) concentrations of Ascorbic acid; after 21 days of treatment, the plant material was extracted, Partially purified, and analyzed for enzyme activity. The polyphenol oxidase was extracted and determined for enzyme activity, phenol content, protein concentration as well as functional group determination using FTIR analysis. The polyphenol oxidase activity decreased with an increase in ascorbic acid concentration. The study revealed that the protein content in the Brinjal hybrid variety had a maximum of 221 µg/ml, whereas the wild brinjal variety possesses 180 µg /ml. The phenolic content of the hybrid Brinjal variety was found to be 67...
Read More
Posted by admin on Jul 31, 2021 in |
The present study was aimed to evaluate the effect of Piperine on the antidiarrhoeal activity of Diphenoxylate. Antidiarrhoeal effect of Diphenoxylate, Piperine and Diphenoxylate in combination with Piperine was subjected to pharmacological evaluation. Antidiarrhoeal effect was evaluated in castor oil and magnesium sulphate induced diarrhoea model while antimotility and antisecretory effect was evaluated in charcoal meal test and castor oil-induced intestinal secretions in mice. Diphenoxylate at a dose of 1 mg/kg produced 43% and 37.71% inhibition of diarrhoea in castor oil and magnesium sulphate induced diarrhoea model respectively. Diphenoxylate at a dose of 1 mg/kg produced 18.47% antimotility effect and 35.79% antisecretory effect. Piperine at a dose of 10 mg/kg showed 18.89% and 20.72% antidiarrhoeal effect in castor oil and magnesium sulphate induced diarrhoea model respectively. Piperine at a dose of 10 mg/kg produced an 11.55% antimotility effect and 27.65% antisecretory effect. Diphenoxylate (1 mg/kg) with Piperine (10 mg/kg) produced 82.48% and 81.20% inhibition of diarrhoea in castor oil and magnesium sulphate induced diarrhoea model respectively. Diphenoxylate (1 mg/kg)...
Read More
Posted by admin on Jul 31, 2021 in |
Oral squamous cell carcinoma (OSCC) is the most commonly occurring malignancy of the oral cavity. Over the years, the incidence and morbidity rate of Oral Cancer patients has increased worldwide. In the last few decades, although oral cancer treatment modalities have advanced, the survival rate of oral cancer patients is very low. Thus, there arises a need for the identification of new drug targets besides the development of new and effective drugs for this disease. This paper describes the development of Quantitative Structure-Activity Relationship (QSAR) models using machine learning techniques such as Multiple Linear Regression (MLR), k-Nearest Neighbor (kNN), and Support Vector Machine (SVM) for predicting the inhibitory activity (IC50) of anti-cancer compounds against HDAC6 protein. After data pre-processing and selection of relevant features, predictive models were developed, and the top two best performing models were selected based on the parameters such as Squared Correlation Coefficient (r2) and Mean Absolute Error (MAE). Moreover, based on this study, an open-source platform (www.inhibpred.com) has been developed, thus facilitating the identification of...
Read More
