Posted by admin on May 31, 2021 in |
Nanotechnology can be applied to deliver and protect antioxidants in order to control the oxidative stress phenomena in several chronic pathologies. Chitosan (CS) and its carboxymethyl derivatives are smart biopolymers that are non-toxic, biocompatible, and biodegradable, and, hence, suitable for various biomedical applications, such as drug delivery gene therapy and tissue engineering. Vitis vinifera (VV) seeds are the major chemotherapeutic agent with antioxidant, anti-inflammatory, antiproliferative, anticancer, and antimicrobial effects. However, the potential of these leaves as a chemotherapeutic agent is limited by their hydrophobicity and poor bioavailability. The chitosan tripolyphosphate (CS/TPP) nanoparticles have been used in this study as an alternative to encapsulate bioactive flavonoids from ethanolic extract of Vitis vinifera seeds. The Vitis vinifera seeds extract-loaded CS (CS-VVE) nanoparticles were characterized using FT-IR. The Zeta sizer and zeta potential confirmed that the particle has 216nm and 50.3mV. This study also found that the CS-VVE NPs shown anticancer activity in human colon cancer cell lines should be explored further for Cytotoxicity studies using MTT assay and tested drug-induced apoptotic...
Read More
Posted by admin on May 31, 2021 in |
The objective of the research work was to design NLCs gel of Acitretin and perform an in-vitro evaluation of different formulations. FTIR and DSC studies revealed that there was no interaction between drug and polymer and with the respective surfactant. A new generation of NLCs consisting of a lipid matrix with a special nanostructure has been developed. These nanostructures improve drug loading and firmly incorporates the drug during storage. The purpose of this study was to prepare Acitretin-loaded NLCs gel effective for topical delivery of Acitretin by using the Hot Homogenization method. Stearic acid as solid lipid, Oleic acid as liquid lipid combination of two types of surfactant: Tween 80 and Sodium lauryl sulphate (SLS) were used to stabilize NLCs dispersion. Physiochemical properties of NLCs gel such as particle size, TEM, entrapment efficiency, and in-vitro release studies were investigated. The formulation in which a combination of ionic and non-ionic surfactant was used to demonstrated good entrapment efficiency, sustained in-vitro release profile. In-vitro release study revealed the biphasic release pattern...
Read More
Posted by admin on May 31, 2021 in |
Prune is a dry form of plum fruit; its botanical name is Prunus domestica characterized by unique nutrients and dietary bioactive profile. Prunes have wide application in traditional medicine and are known for their beneficial role as a laxative in management of non-communicable diseases and bone health. Researches have proved their antioxidant, anticancer, antihyperglycemic, anti-hyperlipidemic, anti-osteoporosis properties. The available evidences were searched and summarized after an extensive search on review of published literature with a focus on exploring the therapeutic and pharmacological effects of prunes. A number of preferred databases were searched using the Pub Med database, Science Direct, SciELO, Google Scholar, Link Springer, and Research Gate. This review investigated the potential mechanisms and effects of dried plums on overall health; the chemical composition of prunes reflects the presence of polyphenols like chlorogenic acids, neochlorogenic acid, caffeic acid, coumaric acid, proanthocyanidins and some other similar compounds, which are beneficial for improving and maintaining health and wellbeing. Prunes are used for treatment of acid dyspepsia, nausea, vomiting, fevers, headaches. Prunes...
Read More
Posted by admin on May 31, 2021 in |
Since 2019-November on world facing whole world is facing an unprecedented health problem. The WHO has said that a pandemic infection are coming with a new virus species of coronavirus is called SARS-CoV-2. Coronavirus 2019 is associated with global health and acute coronary respiratory syndrome coronavirus-2. COVID-19 is widely spread through drip channels. The virus causes mild symptoms in many who have manifested many symptoms, dry cough, fatigue, muscle aches and bruises; Common symptoms include diarrhea, colds, hemoptysis, sore throat and runny nose. Severe infections, which are the main treatment options for critical care patients, include severe lung burns, sepsis, ARDS and septicemia. Here we present nine key research questions related to virus infection, releasing anonymous, treatment, pre-symptomatic viruses, diagnosis, vaccine growth, origins of the virus and also viral infections, etiology, viral infections, clinical picture, treatment and infection. Effective treatment is not yet available. Every day there is an increase in morbidity and mortality, and adherence to the instructions of infection prevention and infection should control government organizations are...
Read More
Posted by admin on May 31, 2021 in |
Ganoderma lucidum total triterpenes were evaluated for anti-inflammatory activity using carrageenan-induced acute and formalin-induced chronic paw oedema models in Swiss albino mice. The total triterpenes, at concentrations 10, 50, and 100 mg/kg b. wt. administered orally, showed 36.96%, 54.35%, 76.09% inhibition of acute and 41.86%, 62.79% and 79.07% inhibition of chronic inflammation. Total triterpenes were also assessed for its effect in attenuating the inflammation and modulating the antioxidant status of Freund’s complete adjuvant (FCA) induced arthritis rats. Total triterpenes when administrated orally, at concentrations 10, 50, and 100mg/kg b. wt., showed 58.73%, 73.02%, and 79.37% inhibition of paw oedema in the arthritis rats. Treatment with total triterpenes enhanced the activities of the antioxidant enzymes (SOD, GPx, and catalase) and restored the level of GSH in arthritic animals. Total triterpene treatment also attenuated the enhanced lipid peroxide levels in FCA-induced rats. All these findings support the strong therapeutic potential of Ganoderma total triterpenes against inflammation...
Read More
