Posted by admin on Apr 30, 2021 in |
The main purpose of the current research work is to enhance solubility and dissolution of BCS Class II drug, Flurbiprofen using liquid-solid compact technology. Flurbiprofen is a non-steroidal anti-inflammatory drug indicated for acute and chronic treatment of rheumatoid arthritis, osteoarthritis, and spondylytis. The rationale to select Flurbiprofen as the model drug is that it belongs to BCS Class II, having poor aqueous solubility of 10.45 ± 3.2μg/ml. Hence an attempt was made to enhance solubility, which may further increase the dissolution profile of the drug. In this regard, several liquisolid compact formulations were prepared for flurbiprofen and subjected to evaluation. They were prepared by using PEG 600 as a non-volatile solvent to dissolve the drug and further converted to freely flowing readily compressible powder using Avicel PH 102 as carrier material and Aerosil 200 as coating material. These liquisolid formulations were subjected to pre-compression rheological studies and post-compression evaluation parameters such as hardness, friability, weight variation, content uniformity, disintegration, and in-vitro dissolution. Results of dissolution profile of formulation TF3...
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Posted by admin on Apr 30, 2021 in |
Sulfonamides, sometimes called sulfa drugs, are the first drug that is largely employed and systematically essential for preventive and chemotherapeutic agents against various bacteria. Sulfonamides possess a wide range of pharmacological activities such as Oral hypoglycemic, antileprotic, anti-epileptic, anti-hypertensive, anti-bacterial, anti-protozoal, anti-fungal, antiretroviral, non-peptidic vasopressin receptor antagonists, anti-cancer, anti-inflammatory, translation initiation inhibitors, and used as a diuretic. The rapid evolution of drug-resistant bacterial and fungal infections has demanded a universal effort to search for new generation sulfonamide derivatives. The sulphonamides or sulfa drugs competitively inhibit folic acid synthesis in microorganisms and subsequently inhibit the multiplication of bacteria but do not actively kill them. These sulfonamides have a variety of synthetic reactions to work with. On the basis of the literature survey, the present review highlights research work in the recent decade, including potential antimicrobial activities of sulfonamides compounds. This review covers current advances related to synthesis and pharmacological effects of sulfonamides, especially in apprehension to anti-microbial...
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Posted by admin on Apr 30, 2021 in |
Tuberculosis (TB) is one of the top ten causes of death worldwide. Presently, one-quarter of the world’s population is thought to be infected with TB. New infections occur in about 1% of the population each year. Tuberculosis is a major global health threat. There is a progressive increase in multidrug-resistant (MDR) and extensively drug-resistant tuberculosis (XDR). Multi drug resistance (MDR)-TB and Extensively drug resistance (XDR)-TB poses a vital challenge to the control of tuberculosis. Numbers of drugs are available in the market for the treatments of tuberculosis as well as many new drugs are also available for the treatment of MDR-TB and XDR-TB. This review article covers most of the different official and reported analytical methods for the estimation of the first line, second line oral, and newer anti-TB drugs. The main objective of this review is to classify, summarize, and discusses the different proposed analytical methods for the estimation of above mentioned anti-TB drugs alone and in combination with other drugs in bulk, pharmaceutical formulation and biological...
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Posted by admin on Apr 30, 2021 in |
Forced degradation studies are a vital tool in pharmaceutical research and development to predict long-term stability. Stress studies should be performed in method development to know drug behavior but can also be performed with method validation for regulatory filling predict stability, and measure impurities. It is especially valuable when little data is free about potential degradation products. Forced degradation studies may help encourage drug advancement in regions like formulation development, manufacturing, and packaging, in which information on substance conduct can be utilized to improve a medication item. Hence it is important to realize the purity profile and conduct of a medication substance under various natural conditions. For stable formulation development, comprehension of synthetic conduct forced degradation pathways and degradants of drug substance and drug product is very important. Therefore, by using different regulatory guidelines in the present review paper, we described the broad overview of forced degradation studies by determining the system to perform stress studies & its methods for isolation and identification of...
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Posted by admin on Apr 30, 2021 in |
To investigate the phytoconstituents and anticancer potential followed by apoptotic studies of H. undatus fruit extracts on HepG-2 cells. Qualitative phytochemical profiling and anti-proliferation activity of Aqueous, Chloroform, Ethyl acetate, Hexane, and Methanol extracts of dragon fruit pulp was carried out. Based on the results of anti-proliferation studies, methanol extract was taken further for apoptotic study by treating HepG-2 cells for nuclear staining using DAPI and GC-MS analysis to elucidate the presence of active compounds. Qualitative phytochemical analysis revealed the presence of carbohydrates, tannins, saponins, anthocyanin, quinones, cardiac glycosides, terpenoids, triterpenoids, phenols, acids, and steroids in aqueous fruit extract. Similarly, chloroform fruit extract showed the presence of carbohydrates, saponins, alkaloids, cardiac glycosides, triterpenoids, phenols, and coumarins. Likewise, Ethyl acetate fruit extract had carbohydrates, tannins, saponins, flavonoids, alkaloids, anthocyanin, cardiac glycosides, terpenoids, triterpenoids, acids, and steroids. In hexane fruit extract, carbohydrate, saponins, anthocyanin, quinones, phenols, and acids were present. But more phytocompouds such as carbohydrates, tannins, saponins, flavonoids, alkaloids, anthocyanin, cardiac glycosides, terpenoids, triterpenoids, phenols, acids, and steroids were found...
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